Combination of budesonide and aminophylline diminished acute lung injury in animal model of meconium aspiration syndrome

Journal of Physiology and Pharmacology

Volumn 59, Issue SUPPL. 6, 2008, Pages 461-471

  Mokra, D ^a   Drgova, A ^a   Mokry, J ^a   Bulikova, J ^a   Pullmann, R ^b   Durdik, P ^a   Petraskova, M ^a   Calkovska, A ^a  

^a University Teaching Hospital in Martin   (Slovakia)

^b Physics and Informatics   (Slovakia)

Author keywords

Aminophylline; Budesonide; Inflammation; Meconium aspiration

Indexed keywords

AMINOPHYLLINE; BUDESONIDE; HISTAMINE; BRONCHODILATING AGENT; OXYGEN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ACUTE LUNG INJURY; AIRFLOW; AIRWAY PRESSURE; ARTICLE; CARDIOVASCULAR EFFECT; COMBINATION CHEMOTHERAPY; DISEASE MARKER; GAS EXCHANGE; LOW DRUG DOSE; LUNG EDEMA; LUNG FUNCTION; MECONIUM ASPIRATION; MONOTHERAPY; NEUTROPHIL; PEROXIDATION; PULMONARY SHUNT; ANIMAL; BLOOD; BLOOD PRESSURE; DRUG EFFECT; HUMAN; IMMUNOASSAY; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE COUNT; LIPID PEROXIDATION; LUNG DISEASE; LUNG FUNCTION TEST; METABOLISM; NEUTROPHIL CHEMOTAXIS; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT; TRACHEA;

AMINOPHYLLINE; ANIMALS; ANIMALS, NEWBORN; BLOOD PRESSURE; BRONCHODILATOR AGENTS; BUDESONIDE; HUMANS; IMMUNOASSAY; INFANT, NEWBORN; INJECTIONS, INTRAVENOUS; LEUKOCYTE COUNT; LIPID PEROXIDATION; LUNG DISEASES; MECONIUM ASPIRATION SYNDROME; NEUTROPHIL INFILTRATION; OXYGEN; RABBITS; RESPIRATORY FUNCTION TESTS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRACHEA;

EID: 64549139313     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Tripathi S, Saili A. The effect of steroids on the clinical course and outcome of neonates with meconium aspiration syndrome. J Trop Pediatr 2007; 53: 8-12.
2. Mokra D, Mokry J, Drgova A, Bulikova J, Petraskova M, Calkovska A. Single-dose vs. two- dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits. J Physiol Pharmacol 2007; 58 (Suppl 5): 379-387.
3. Mokra D, Mokry J, Drgova A, Petraskova M, Bulikova J, Calkovska A. Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits. J Physiol Pharmacol 2007; 58 (Suppl 5): 389-398.
4. Korhonen K, Kiuru A, Svedstrom E, Kaapa P. Pentoxyfylline reduces regional inflammatory and ventilatory disturbances in meconium-exposed piglet lungs. Pediatr Res 2004; 56: 901-906.
5. Mokra D, Mokry J, Tatarkova Z, Redfors B, Petraskova M, Calkovska A. Aminophylline treatment in meconium-induced acute lung injury in a rabbit model. J Physiol Pharmacol 2007; 58 (Suppl 5): 399-407.
6. Mokra D, Mokry J. Inflammation in meconium aspiration syndrome: targets for pharmacological modulation. Curr Pediatr Rev 2007; 3: 248-263.
7. Schacke H, Docke W-D, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacology & Therapeutics 2002; 96: 23-43.
8. Barnes PJ. Theophylline in chronic obstructive pulmonary disease. New horizons. Proc Am Thorac Soc 2005; 2: 334-339.
9. Barnes PJ. Drugs for asthma. Br J Pharmacol 2006; 147: S297-S303.
10. Sevecova D, Calkovska A, Drgova A, Javorka M, Petraskova M, Javorka K. Lung lavage using high-frequency jet ventilation in rabbits with meconium aspiration. Acta Paediatr 2003; 92: 314-319.
11. Evans DJ, Taylor DA, Zetterstrom O, Chung KF, O'Connor BJ, Barnes PJ. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N Engl J Med 1997; 337: 1412-1418.
12. Buttgereit F, Scheffold A. Rapid glucocorticoid effects on immune cells. Steroids 2002; 67: 529-534.
13. Stellato C. Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc 2004; 1: 255-263.
14. Falkenstein E, Tillmann HC, Christ M, Feuring M, Wehling M. Multiple actions of steroid hormones - a focus on rapid, nongenomic effects. Pharmacol Rev 2000; 52: 513-556.
15. Mokra D, Calkovska A, Tonhajzerova I, Petraskova M, Bulikova J, Redfors B. Dexamethasone treatment improved lung functions in meconium-instilled rabbits, but influenced cardiovascular variables. Bratisl Med J 2008; 109: 95-101.
16. Mokra D, Tonhajzerova I, Mokry J, Petraskova M, Calkovska A, Javorka K. Rapid cardiovascular effects of dexamethasone in rabbits with meconium-induced acute lung injury. Can J Physiol Pharmacol - in press.
17. Muller M, van Osten B, Schmid R et al. Theophylline kinetics in peripheral tissues in vivo in humans. Naunyn Schmiedebergs Arch Pharmacol 1995; 352: 438-441.
18. Barnes PJ. Transcription factors in airway diseases. Lab Invest 2006; 86: 867-872.
19. Lim S, Jatakanon A, Gordon D, Macdonald C, Chung KF, Barnes PJ. Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. Thorax 2000; 55: 837-841.