Pentoxifylline reduces regional inflammatory and ventilatory disturbances in meconium-exposed piglet lungs

Pediatric Research

Volumn 56, Issue 6, 2004, Pages 901-906

  Korhonen, Kalle ^a,b,c   Kiuru, Aaro ^b   Svedström, Erkki ^b   Kääpä, Pekka ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC)   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOPEROXIDASE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

AERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERIAL PRESSURE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HEART RATE; LUNG ALVEOLUS MACROPHAGE; LUNG DIFFUSION; LUNG INJURY; LUNG LAVAGE; LUNG VENTILATION; MACROPHAGE; MECONIUM ASPIRATION; NEUTROPHIL; NEWBORN; NONHUMAN; PNEUMONIA; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS; BLOOD PRESSURE; BRONCHOALVEOLAR LAVAGE FLUID; ENZYME INHIBITORS; HUMANS; INFANT, NEWBORN; MACROPHAGES, ALVEOLAR; MECONIUM ASPIRATION SYNDROME; PENTOXIFYLLINE; PNEUMONIA, ASPIRATION; SWINE;

EID: 9244255268     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000145256.19073.E4     Document Type: Article

References (43)

1. Cleary GM, Wiswell TE 1998 Meconium-stained amniotic fluid and the meconium aspiration syndrome. An update. Pediatr Clin North Am 45:511-529
2. Wiswell TE, Bent RC 1993 Meconium staining and the meconium aspiration syndrome. Unresolved issues. Pediatr Clin North Am 40:955-981
3. Tran N, Lowe C, Sivieri EM, Shaffer TH 1980 Sequential effects of acute meconium obstruction on pulmonary function. Pediatr Res 14:34-38
4. Clark DA, Nieman GF, Thompson JE, Paskanik AM, Rokhar JE, Bredenberg CE 1987 Surfactant displacement by meconium free fatty acids: an alternative explanation for atelectasis in meconium aspiration syndrome. J Pediatr 110:765-770
5. Moses D, Holm BA, Spitale P, Liu MY, Enhorning G 1991 Inhibition of pulmonary surfactant function by meconium. Am J Obstet Gynecol 164:477-481
6. Davey AM, Becker JD, Davis JM 1993 Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model. Pediatr Pulmonol 16:101-108
7. Kojima T, Hattori K, Fujiwara T, Sasai-Takedatsu M, Kobayashi Y 1994 Meconium-induced lung injury mediated by activation of alveolar macrophages. Life Sci 54:1559-1562
8. Frantz ID, Wang NS, Thach BT 1975 Experimental meconium aspiration: effects of glucocorticotd treatment. J Pediatr 86:438-441
9. Yeh TF, Srinivasan G, Harris V, Pildes RS 1977 Hydrocortisone therapy in meconium aspiration syndrome: a controlled study. J Pediatr 90:140-143
10. Khan AM, Shabarek FM, Kutchback JW, Lally KP 1999 Effects of dexamethasone on meconium aspiration syndrome in newborn piglets. Pediatr Res 46:179-183
11. Holopainen R, Laine J, Halkola L, Aho H, Kaapa P 2001 Dexamethasone treatment attenuates pulmonary injury in piglet meconium aspiration. Pediatr Res 49:162-168
12. Wiswell TE 2001 Advances in the treatment of the meconium aspiration syndrome. Acta Paediatr Suppl 90:28-30
13. Dettelbach HR, Aviado DM 1985 Clinical pharmacology of pentoxifylline with special reference to its hemorrheologic effect for the treatment of intermittent claudication. J Clin Pharmacol 25:8-26
14. Mandell GL 1995 Cytokines, phagocytes, and pentoxifylline. J Cardiovasc Pharmacol 25 Suppl 2:S20-S22
15. Sullivan GW, Carper HT, Novick WJ Jr, Mandell GL 1988 Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline. Infect Immun 56:1722-1729
16. Mandell GL 1988 ARDS, neutrophils, and pentoxifylline. Am Rev Respir Dis 138:1103-1105
17. Raffin TA 1990 Acute lung injury and pentoxifylline. Crit Care Med 18:1485-1486
18. Albertson TE, Marelich GP 1998 Pharmacologic adjuncts to mechanical ventilation in acute respiratory distress syndrome. Crit Care Clin 14:581-610
19. Welsh CH, Lien D, Worthen GS, Weil JV 1988 Pentoxifylline decreases endotoxin-induced pulmonary neutrophil sequestration and extravascular protein accumulation in the dog. Am Rev Respir Dis 138:1106-1114
20. Lindsey HJ, Kisala JM, Ayala A, Lehman D, Herdon CD, Chaudry IH 1994 Pentoxifylline attenuates oxygen-induced lung injury. J Surg Res 56:543-548
21. Lilly CM, Sandhu JS, Ishizaka A, Harada H, Yonemaru M, Larrick JW, Shi TX, O'Hanley PT, Raffin TA 1989 Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am Rev Respir Dis 139:1361-1368
22. Seear MD, Hannam VL, Kaapa P, Raj JU, O'Brodovich HM 1990 Effect of pentoxifylline on hemodynamics, alveolar fluid reabsorption, and pulmonary edema in a model of acute lung injury. Am Rev Respir Dis 142:1083-1087
23. Kudoh I, Ohtake M, Nishizawa H, Kurahashi K, Hattori S, Okumura F, Pittet JF, Wiener-Kronish J 1995 The effect of pentoxifylline on acid-induced alveolar epithelial injury. Anesthesiology 82:531-541
24. Korhonen K, Soukka H, Halkola L, Peuravuori H, Aho H, Pulkki K, Kero P, Kaapa PO 2003 Meconium induces only localized inflammatory lung injury in piglets. Pediatr Res 54:192-197
25. Holopainen R, Soukka H, Halkola L, Kaapa P 1998 Meconium aspiration induces a concentration-dependent pulmonary hypertensive response in newborn piglets. Pediatr Pulmonol 25:107-113
26. Grisham MB, Benoit JN, Granger DN 1990 Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol 186:729-742
27. Kiuru A, Svedstrom E, Kuuluvainen I 1991 Dynamic imaging of pulmonary ventilation. Description of a novel digital fluoroscopic system. Acta Radiol 32:114-119
28. Svedstrom EJ, Kiuru A, Puhakka HJ 1990 Dynamic imaging of pulmonary ventilation in children using digital subtraction radiography. Acta Radiol 31:53-58
29. Tyler DC, Murphy J, Cheney FW 1978 Mechanical and chemical damage to lung tissue caused by meconium aspiration. Pediatrics 62:454-459
30. Soukka H, Rautanen M, Halkola L, Kero P, Kaapa P 1997 Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs. Pediatr Pulmonol 23:205-211
31. Strieter RM, Kunkel SL 1994 Acute lung injury: the role of cytokines in the elicitation of neutrophils. J Investig Med 42:640-651
32. Fujishima S, Aikawa N 1995 Neutrophil-mediated tissue injury and its modulation. Intensive Care Med 21:277-285
33. da Costa DE, Nair AK, Pai MG, Al Khusatby SM 2001 Steroids in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. Eur J Pediatr 160:150-153
34. Soukka H, Halkola L, Aho H, Rautanen M, Kero P, Kaapa P 1997 Methylprednisolone attenuates the pulmonary hypertensive response in porcine meconium aspiration. Pediatr Res 42:145-150
35. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB 1990 Tumor necrosis factor-alpha mediates acid aspiration-induced systemic organ injury. Ann Surg 212:513-519
36. Zagariya A, Bhat R, Uhal B, Navale S, Freidine M, Vidyasagar D 2000 Cell death and lung cell histology in meconium aspirated newborn rabbit lung. Eur J Pediatr 159:819-826
37. Stephens KE, Ishizaka A, Larrick JW, Raffin TA 1988 Tumor necrosis factor causes increased pulmonary permeability and edema. Comparison to septic acute lung injury. Am Rev Respir Dis 137:1364-1370
38. Imai Y, Kawano T, Iwamoto S, Nakagawa S, Takata M, Miyasaka K 1999 Intratracheal anti-tumor necrosis factor-alpha antibody attenuates ventilator-induced lung injury in rabbits. J Appl Physiol 87:510-515
39. Balibrea-Cantero JL, Arias-Diaz J, Garcia C, Torres-Melero J, Simon C, Rodriguez JM, Vara E 1994 Effect of pentoxifylline on the inhibition of surfactant synthesis induced by TNF-alpha in human type II pneumocytes. Am J Respir Crit Care Med 149:699-706
40. Jones CA, Cayabyab RG, Kwong KY, Stotts C, Wong B, Hamdan H, Minoo P, deLemos RA 1996 Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr Res 39:966-975
41. Zabel P, Schade FU 1994 Pentoxifylline and tumour necrosis factor-induced lung injury. Eur Respir J 7:1389-1391
42. Marques LJ, Zheng L, Poulakis N, Guzman J, Costabel U 1999 Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am J Respir Crit Care Med 159:508-511
43. Creamer KM, McCloud LL, Fisher LE, Ehrhart IC 2001 Pentoxifylline rescue preserves lung function in isolated canine lungs injured with phorbol myristate acetate. Chest 119:1893-1900