Relaxin and maternal lactocrine programming of neonatal uterine development

Annals of the New York Academy of Sciences

Volumn 1160, Issue , 2009, Pages 158-163

  Bartol, Frank F ^a   Wiley, Anne A ^a   Bagnell, Carol A ^b  

^a AUBURN UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Development; Lactocrine programming; Neonate; Pig; Relaxin; RXFP1; Uterus

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ANTAGONIST; FULVESTRANT; G PROTEIN COUPLED RECEPTOR; PROTEIN RXFP1; RELAXIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

AGE; BIRTH; CONFERENCE PAPER; DOMESTIC PIG; ENDOCRINE SYSTEM; ENDOMETRIUM; GENE; GENE EXPRESSION; LACTOCRINE; MILK; MOTHER FETUS RELATIONSHIP; NONHUMAN; PARACRINE SIGNALING; PERINATAL DEVELOPMENT; PERINATAL PERIOD; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; RXFP1 GENE; SIGNAL TRANSDUCTION; UTERUS;

MAMMALIA; SUIDAE; SUS; SUS SCROFA DOMESTICA;

EID: 64549115402     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03820.x     Document Type: Conference Paper

References (24)

1. Bartol, F.F., A.A. Wiley & C.A. Bagnell. 2006. Uterine development and endometrial programming. In Control of Pig Reproduction VII. C.J. Asworth & R.R. Kraeling, Eds.: 113-130. Nottingham University Press. Nottingham, UK.
2. Bartol, EE, A.A. Wiley, T.E. Spencer, et al. 1993. Early uterine development in pigs. J. Reprod. Fertil. Suppl. 48: 99-116.
3. Gray, C.A., F.F. Bartol, B.J. Tarleton, et al. 2001. Developmental biology of uterine glands. Biol. Reprod. 65: 1311-1323.
4. Bartol, F.F., A.A. Wiley, J.G. Floyd, et al. 1999. Uterine differentiation as a foundation for subsequent fertility. J. Reprod. Fertil. Suppl. 54: 287-302.
5. Bartol, F.F., A.A. Wiley & C.A. Bagnell. 2008. Epigenetic programming of porcine endometrial function and the lactocrine hypothesis. Reprod. Domest. Anim. 43 (Suppl. 2): 273-279.
6. Masters, R.A., B.D. Crean, W. Yan, et al. 2007. Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin. Domest. Anim. Endocrinol. 33: 335-346.
7. Tarleton, B.J., A.A. Wiley, T.E. Spencer, et al. 1998. Ovary-independent estrogen receptor expression in neonatal porcine endometrium. Biol. Reprod. 58: 1009-1019.
8. Yao, L., A.I. Agoulnik, P.S. Cookes, et al. 2008. Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina. Endocrinology 149: 2072-2079.
9. Yan, W., R.A. Bathgate, A.L. Frankshun, et al. 2006. Expression of LGR7 and LGR8 by neonatal porcine uterine tissues and transmission of milk-borne relaxin into the neonatal circulation by suckling. Endocrinology 147: 4303-4310.
10. Tarleton, B.J., A.A. Wiley & F.F. Bartol. 1999. Endometrial development and adenogenesis in the neonatal pig: Effects of estradiol valerate and the antiestrogen ICI 182, 780. Biol. Reprod. 61: 253-263.
11. Tarleton, B.J., A.A. Wiley & F.F. Bartol. 2001. Neonatal estradiol exposure alters uterine morphology and endometrial transcriptional activity in prepubertal gilts. Domest. Anim. Endocrinol. 21: 111-125.
12. Bathgate, R.A., R. Ivell, B.M. Sanborn, et al. 2006. International Union of Pharmacology LVII: Recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol. Rev. 58: 7-31.
13. Yan, W, P.L. Ryan, F.F. Bartol, et al. 2006. Uterotrophic effects of relaxin related to age and estrogen receptor activation in neonatal pigs. Reproduction 131: 943-950.
14. Ivell, R., M. Balvers, Y. Pohnke, et al. 2003. Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates. Reprod. Biol. Endocrinol. 1: 114.
15. Yan, W., J. Chen, A.A. Wiley, et al. 2008. Relaxin (RLX) and estrogen affect estrogen receptor-alpha, vascular endothelial growth factor and RLX receptor expression in the neonatal porcine uterus and cervix. Reproduction 135: 705-712.
16. Pillai, S.B., L.C. Rockwell, O.D. Sherwood, et al. 1999. Relaxin stimulates uterine edema via activation of estrogen receptors: Blockade of its effects using ICI 182, 780, a specific estrogen receptor antagonist. Endocrinology 140: 2426-2429.
17. Maseelall, P. et al. 2008. Relaxin receptor LGR7 is regulated by estrogen. Ann. N. Y. Acad. Sci. 1160: 91-92.
18. Bagnell, C. A., B.G. Steinetz & F.F. Bartol. 2008. Milk-borne relaxin and the lactocrine hypothesis for maternal programming of neonatal tissues. Ann. N. Y. Acad. Sci. 1160: 152-157.
19. Frankshun, A.-L., T.-Y Ho, B.G. Steinetz, et al. 2008. Biological activity of relaxin in porcine milk. Ann. N. Y. Acad. Sci. 1160: 164-168.
20. Layden, S.S. & G.W Tregear. 1996. Purification and characterization of porcine prorelaxin. J. Biochem. Biophys. Methods 31: 69-80.
21. Sherwood, O.D. 1994. Relaxin. In The Physiology of Reproduction. E. Knobil & J. Neill, Eds.: 861-1009. Raven Press. New York, NY.
22. Hausman, G.J., S.P. Poulos, R.L. Richardson, et al. 2006. Secreted proteins and genes in fetal and neonatal pig adipose tissue and stromal-vascular cells. J. Anim. Sci. 84: 1666-1681.
23. Knox, R.V., Z. Zhang, B.N. Day, et al. 1994. Identification of relaxin gene expression and protein localization in the uterine endometrium during early pregnancy in the pig. Endocrinology 135: 2517-2525.
24. Palejwala, S., L. Tseng, A. Wojtczuk, et al. 2002. Relaxin gene and protein expression and its regulation of procollagenase and vascular endothelial growth factor in human endometrial cells. Biol. Reprod. 66: 1743-1748.