Changes in serum levels of receptor activator of nuclear factor-κB ligand, osteoprotegerin, IL-6 and TNF-α in patients with a concomitant head injury and fracture

Archives of Orthopaedic and Trauma Surgery

Volumn 129, Issue 5, 2009, Pages 711-718

  Lee, Jung Sub ^a   Ryu, Chang Hoon ^a   Moon, Nam Hoon ^a   Kim, Seong Jang ^a   Park, Shin Young ^a   Suh, Kuen Tak ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

Fracture; Head injury; IL 6; OPG; RANKL

Indexed keywords

INTERLEUKIN 6; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; BRAIN CONTUSION; BRAIN HEMORRHAGE; CALLUS; CLAVICLE FRACTURE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; FEMUR FRACTURE; FOOT FRACTURE; FOREARM FRACTURE; FRACTURE; FRACTURE HEALING; HEAD INJURY; HUMAN; HUMERUS FRACTURE; MALE; METACARPAL BONE FRACTURE; PELVIS FRACTURE; PRIORITY JOURNAL; RIB FRACTURE; SKULL FRACTURE; SUBDURAL HEMATOMA; TIBIA FRACTURE;

ADULT; COMORBIDITY; CRANIOCEREBRAL TRAUMA; FEMORAL FRACTURES; FRACTURE HEALING; FRACTURES, BONE; GLASGOW COMA SCALE; HEMATOMA, SUBDURAL; HUMANS; HUMERAL FRACTURES; INTERLEUKIN-6; INTRACRANIAL HEMORRHAGE, TRAUMATIC; MALE; MIDDLE AGED; OSTEOPROTEGERIN; RANK LIGAND; TIBIAL FRACTURES; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 64449087656     PISSN: 09368051     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00402-008-0632-8     Document Type: Article

References (30)

1. Balto K, Sasaki H, Stashenko P (2001) Interleukin-6 deficiency increases inflammatory bone destruction. Infect Immun 69:744-750
2. Beeton CA, Chatfield D, Brooks RA, Rushton N (2004) Circulating levels of interleukin-6 and its soluble receptor in patients with head injury and fracture. J Bone Joint Surg Br 86:912-917
3. Black K, Garrett IR, Mundy GR (1991) Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology 128:2657-2659
4. Einhorn TA, Majeska RJ, Rush EB, Levine PM, Horowitz MC (1995) The expression of cytokine activity by fracture callus. J Bone Miner Res 10:1272-1281
5. Felver ME, Mezey E, McGuire M, Mitchell MC, Herlong HF, Veech GA, Veech RL (1990) Plasma tumor necrosis factor alpha predicts decreasing long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res 14:255-259
6. Feuerherm AJ, Borset M, Seidel C, Sundan A, Leistad L, Ostensen M, Faxvaag A (2001) Elevated levels of osteoprotegerin (OPG) and hepatocyte growth factor (HGF) in rheumatoid arthritis. Scand J Rheumatol 30:229-234
7. Feyen JH, Elford P, Di Padova FE, Trechsel U (1989) Interleukin-6 is produced by bone and modulated by parathyroid hormone. J Bone Miner Res 4:633-638
8. Hack CE, De Groot ER, Felt-Bersma RJ, Nuijens JH, Strack Van Schijndel RJ, Eerenberg-Belmer AJ, Thijs LG, Aarden LA (1989) Increased plasma levels of interleukin-6 in sepsis. Blood 74:1704-1710
9. Haynes DR, Crotti TN, Loric M, Bain GI, Atkins GJ, Findlay DM (2001) Osteoprotegerin and receptor activator of nuclear factor κB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint. Rheumatology (Oxford) 40:623-630
10. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T (1990) IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303
11. Kalabalikis P, Papazoglou K, Gouriotis D, Papadopoulos N, Kardara M, Papageorgiou F, Papadatos J (1999) Correlation between serum IL-6 and CRP levels and severity of head injury in children. Intensive Care Med 25:288-292
12. Khosla S, Arrighi HM, Melton LJ III, Atkinson EJ, O'Fallon WM, Dunstan C, Riggs BL (2002) Correlates of osteoprotegerin levels in women and men. Osteoporos Int 13:394-399
13. Kimble RB, Bain S, Pacifici R (1997) The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J Bone Miner Res 12:935-941
14. Kon T, Cho TJ, Aizawa T, Yamazaki M, Nooh N, Graves D, Gerstenfeld LC, Einhorn TA (2001) Expression of osteoprotegerin, receptor activator of NF-κB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res 16:1004-1014
15. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176
16. Masi L, Simonini G, Piscitelli E, DelMonte F, Giani T, Cimaz R, Vierucci S, Brandi ML, Falcini F (2004) Osteoprotegerin (OPG)/RANK-L system in juvenile idiopathic arthritis: Is there a potential modulating role for OPG/RANK-L in bone injury? J Rheumatol 31:986-991
17. Ott L, McClain CJ, Gillespie M, Young B (1994) Cytokines and metabolic dysfunction after severe head injury. J Neurotrauma 11:447-472
18. Pacifici R (1996) Estrogen, cytokines and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res 11:1043-1051
19. Perkins R, Skirving AP (1987) Callus formation and the rate of healing of femoral fractures in patients with head injuries. J Bone Joint Surg Br 69:521-524
20. Rogers A, Eastell R (2005) Circulating osteoprotegerin and receptor activator for nuclear factor κB Ligand: Clinical utility in metabolic bone disease assessment. J Clin Endocrinol Metab 90:6323-6331
21. Saidenberg-Kermanac'h N, Cohen-Solal M, Bessis N, De Vernejoul MC, Boissier MC (2004) Role for osteoprotegerin in rheumatoid inflammation. Joint Bone Spine 71:9-13
22. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ (1997) Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:309-319
23. Singhal A, Baker AJ, Hare GM (2002) Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury. J Neurotrauma 19:929-937
24. Spencer RF (1987) The effect of head injury on fracture healing: A quantitative assessment. J Bone Joint Surg Br 69:525-528
25. Stone MH, Newman RJ, Mukherjee SK (1987) Accelerated fracture union in association with severe head injury. Injury 18:241-246
26. Szalay F, Hegedus D, Lakatos PL, Tornai I, Bajnok E, Dunkel K, Lakatos P (2003) High serum osteoprotegerin and low RANKL in primary biliary cirrhosis. J Hepatol 38:395-400
27. Taniguchi T, Koido Y, Aiboshi J, Yamashita T, Suzaki S, Kurokawa A (1999) The ratio of interleukin-6 to interleukin-10 correlated with severity in patients with chest and abdominal trauma. Am J Emerg Med 17:548-551
28. Trofilmov S, Pantsulaia I, Kobyliansky E, Livshits G (2004) Circulating levels of receptor activator of nuclear factor-kappaB ligand/ osteoprotegerin/macrophage-colony stimulating factor in a presumably healthy human population. Eur J Endocrinol 150:305-311
29. Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T (1989) The complex pattern of cytokines in serum from patients with meningococcal septic shock: Association between interleukin-6, interleukin-1 and fatal outcome. J Exp Med 169:333-338
30. Waage A, Halstensen A, Espevik T (1987) Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1:355-357