IgE antibodies to recombinant pollen allergens (Phl p 1, Phl p 2, Philp p 5, and Bet v 2) account for a high percentage of grass pollen-specific IgE

Journal of Allergy and Clinical Immunology

Volumn 101, Issue 2 I, 1998, Pages 258-264

  Niederberger, Verena ^a   Laffer, Sylvia ^a   Fröschl, Renate ^a   Kraft, Dietrich ^a   Rumpold, Helmut ^a   Kapiotis, Sonja ^a   Valenta, Rudolf ^a   Spitzauer, Susanne ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bet v 2; Grass pollen allergy; IgE cross reactivity; Immunoabsorption; Phl p 1; Phl p 2; Phl p 5; Profilin; Recombinant pollen allergens

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E;

ADULT; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; CLINICAL ARTICLE; CROSS REACTION; FEMALE; GRASS; HUMAN; IMMUNOADSORPTION; IMMUNOTHERAPY; MALE; MOLECULAR CLONING; POLLEN ALLERGY; PRIORITY JOURNAL;

ADULT; ALLERGENS; ANTIBODY SPECIFICITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; HYPERSENSITIVITY; IMMUNOBLOTTING; IMMUNOGLOBULIN E; MALE; PLANT EXTRACTS; PLANT PROTEINS; POACEAE; POLLEN; RECOMBINANT PROTEINS;

EID: 0031924659     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70391-4     Document Type: Article

References (34)

1. Freidhoff LR, Ehrlich-Kautzky E, Grant JH, Meyers DA, Marsh DG. A study of the human immune response to Lolium perenne (rye) pollen and its components, Loi p I and Loi p II (rye I and rye II). J Allergy Clin Immunol 1986;78:1190-201.
2. Gleich GJ, Jacob GL. Immunoglobulin E antibodies to pollen allergens account for a high percentage of total immunoglobulin E protein. Science 1975;190:1106-8.
3. King TP, Hoffmann D, Lowenstein H, Marsh DG, Platts-Mills TA, Thomas W. Allergen nomenclature (WHO). J Allergy Clin Immunol 1995;96:5-14.
4. Valenta R, Steinberger P, Duchene M, Kraft D. Immunological and structural similarities among allergens: prerequisite for a specific and component-based therapy of allergy. Immunol Cell Biol 1996;74:187-94.
5. Johnson P, Marsh DG. "Isoallergens" from rye grass pollen. Nature 1965;206:935-7.
6. Laffer S, Valenta R, Vrtala S, Susana M, vanRee R, Kraft D, et al. Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species. J Allergy Clin Immunol 1994;94:689-98.
7. Ansari AA, Shenbagamurthi P, Marsh DG. Complete primary structure of a Lolium perenne (perennial rye grass) pollen allergen, Loi p III: comparison with known Loi p I and II sequences. Biochemistry 1989;28:8665-70.
8. Sidoli A, Tamborini E, Giuntini I, Levi S, Volonte G, Paini C, et al. Cloning, expression and immunological characterization of recombinant Lolium perenne allergen Loi p II. J Biol Chem 1993;268:21819-25.
9. Dolecek C, Vrtala S, Laffer S, Steinberger P, Kraft D, Scheiner O, et al. Molecular characterization of Phl p H, a major timothy grass (Phleum pratense) pollen allergen. FEBS Lett 1993;335:299-304.
10. Fischer S, Grote M, Fahlbusch B, Müller WD, Kraft D, Valenta R. Characterization of Ph p 4, a major timothy grass (Phleum pratense) pollen allergen. J Allergy Clin Immunol 1996:98:189-98.
11. Matthiesen F, Lowenstein H. Group V allergens in grass pollens. II. Investigation of group V allergens in pollens from 10 grasses. Clin Exp Allergy 1991;21:309-20.
12. Vrtala S, Sperr WR, Reimitzer I, vanRee R, Laffer S, Müller D, et al. cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Ph; p V allergen. J Immunol 1993;151:4773-81.
13. Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, et al. Identification of profilin as a novel pollen allergen: IgE autoreactivity in sensitized individuals. Science 1991;253:557-60.
14. Valenta R, Duchêne M, Ebner C, Valent P, Sillaber C, Deviller P, et al. Profilins constitute a novel family of functional plant panallergens. J Exp Med 1992;175:377-85.
15. Valenta R, Ball T, Vrtala S, Duchene M, Kraft D, Scheiner O. cDNA cloning and expression of timothy grass (Phleum pratense) pollen profilin in Escherichia coli: comparison with birch pollen profilin. Biochem Biophys Res Commun 1994;199:106-18.
16. Vrtala S, Wiedemann P, Mittermann I, Eichler HG, Sperr WR, Valent P, et al. High-level expression in Escherichia coli and purification of recombinant plant profilins: comparison of IgE-binding capacity and allergenic activity. Biochem Biophys Res Commun 1996;226:42-50.
17. Matthiesen F, Friberg L, Olsen M, Lowenstein H. Purification and characterization of the Phleum pratense (timothy) pollen allergen Phl p 6. In: Sehon AH, Kraft D, editors. Molecular biology and immunology of allergens. Boca Raton (FL): CRC Press; 1993. p. 189-91.
18. Petersen A, Bufe A, Schramm G, Schlaak M, Becker WM. Characterization of the allergen group VI in timothy grass pollen (Phl p 6) II. cDNA Cloning of Phl p 6 and structural comparison to grass group 6 allergen. Int Arch Allergy Immunol 1995;108:55-9.
19. vanRee R, Hoffmann DR, van Dijk W, Brodard V, Mahieu K, Koeleman CA, et al. Loi p 11, a new major grass pollen allergen, is a member of a family of soybean trypsin inhibitor-related proteins. J Allergy Clin Immunol 1995;95:970-8.
20. Suphioglu C, Ferreira F, Knox RB. Molecular cloning and immunological characterization of Cyn d 7, a novel calcium-binding allergen from Bermuda grass pollen. FEBS Lett 1997;402:167-72.
21. Laffer S, Vrtala S, Duchene M, vanRee R, Kraft D, Scheiner O, et al. IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens. J Allergy Clin Immunol 1994;94:88-94.
22. Valenta R, Vrtala S, Ebner C, Kraft D, Scheiner O. Diagnosis of grass pollen allergy with recombinant timothy grass (Phleum pratense) pollen allergens. Int Arch Allergy Immunol 1992;97:287-94.
23. Laffer S, Spitzauer S, Susani M, Pairleitner H, Schweiger C, Grönlund H, et al. Comparison of recombinant timothy grass pollen allergens with natural extract for diagnosis of grass pollen allergy in different populations. J Allergy Clin Immunol 1996;98:652-8.
24. Vrtala S, Susani M, Sperr WR, Valent P, Laffer S, Dolecek C, et al. Immunologic characterization of purified recombinant timothy grass pollen (Phleum pratense) allergens (Phi p 1, Phi p 2, Phi p 5). J Allergy Clin Immunol 1996;97:781-7.
25. Laffer S, Duchêne M, Reimitzer I, Susani M, Mannhalter C, Kraft D, et al. Common IgE-epitopes of recombinant Phl p I, the major timothy grass pollen allergen and natural group I grass pollen isoallergens. Mol Immunol 1996;33:417-26.
26. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
27. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
28. Susani M, Jertschin P, Dolecek C, Sperr WR, Valent P, Ebner C, et al. High level expression of birch pollen profilin (Bet v 2) in Escherichia coli: purification and characterization of the recombinant allergen. Biochem Biophys Res Commun 1995;215:250-63.
29. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4.
30. vanRee R, Clemens JGC, Aalbers M, Stapel SO, Aalberse RC. Characterization with monoclonal and polyclonal antibodies of a new major allergen from grass pollen in the group I molecular weight range. J Allergy Clin Immunol 1989;83:144-51.
31. Valuer P, Dechamp C, Valenta R, Vial O, Deviller P. Purification and characterization of an allergen from celery immunochemically related to an allergen present in several other plant species. Identification as a profilin. Clin Exp Allergy 1992;22:774-82.
32. Fahlbusch B, Müller WD, Diener CH, Jäger L. Detection of cross-reactive determinants in grass pollen extracts using monoclonal antibodies against group IV and group V allergens. Clin Exp Allergy 1993;23:51-60.
33. Valenta R, Laffer S, Vrtala S, Grönlund H, Elfman L, Sperr WR, et al. Recombinant allergens. Steps on the way to diagnosis and therapy of type I allergy. In: Sehon AH, HayGlass KT, Kraft D, editors. New horizons in allergy immunotherapy. New York: Plenum Press; 1996. p. 185-96.
34. Wihl JA, Ipsen H, Petersen BN, Munch EP, Janniche H, Loewenstein H. Immunotherapy with partially purified and standardized tree pollen extracts. Allergy 1988;43:370-7.