Topical 0.05% cyclosporin in the treatment of dry eye

Expert Opinion on Pharmacotherapy

Volumn 5, Issue 10, 2004, Pages 2099-2107

  Perry, Henry D ^a   Donnenfeld, Eric D ^a  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

Author keywords

0.05 cyclosporin; Dry eyes; Immunotherapy; Keratoconjunctivitis sicca; Restasis

Indexed keywords

ARTIFICIAL TEAR; CARBOMER; CASTOR OIL; CD3 ANTIGEN; CYCLOSPORIN A; CYTOKINE; DRUG VEHICLE; DYE; ENDURA; GLYCEROL; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; POLYSORBATE 80; ROSE BENGAL;

AGE; ANTIINFLAMMATORY ACTIVITY; AQUEOUS HUMOR FLOW; BURNING SENSATION; CLINICAL TRIAL; CORNEA DISEASE; DIAGNOSTIC PROCEDURE; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG APPROVAL; DRUG DOSE REGIMEN; DRUG FORMULATION; DRUG MECHANISM; DRY EYE; EVAPORATION; EYE INFECTION; EYE PAIN; FLUORESCENCE ANALYSIS; FOOD AND DRUG ADMINISTRATION; HUMAN; INFLAMMATION; KIDNEY DYSFUNCTION; LIVER DYSFUNCTION; PATHOGENESIS; REVIEW; SCREENING TEST; T LYMPHOCYTE; TREATMENT OUTCOME; UNITED STATES;

ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CLINICAL TRIALS, PHASE III; CYCLOSPORINE; DRY EYE SYNDROMES; EMULSIONS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; OPHTHALMIC SOLUTIONS;

EID: 6444243384     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.5.10.2099     Document Type: Review

References (24)

1. SCHAUMBERG DA, SULLIVAN DA, BURING JE, DANA MR: Prevalence of dry eye syndrome among US women. Am. J. Ophthalmol. (2003) 136 318-326.
2. FOX RI, HOWELL FV, BONE RC, MICHELSON P: Primary Sjögren's syndrome: clinical and immunopathologic features. Sem. Arthritis Rheum. (1984) 14:77-105.
3. LIN PY,TSAI SY, CHENG CY, LIU JH, CHOU P. HSU WM: Prevalence of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study. Ophthalmology (2003) 110(6):1096-1101.
4. SCHEIN OD, TIELSCH JM, MUNOZ B et al.: Relation between signs and symptoms of dry eye in the elderly. A population-based perspective. Ophthalmology (1997) 104:1395-1401.
5. AFONSO A, MONROY D, STERN ME et al.: Correlation of tear Fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology (1999) 106:803-810.
6. MACRI A, PFLUGFELDERS: Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. Arch. Ophthalmol. (2000) 118:1632-1638.
7. CHODOSH J, DIX RD, HOWELL RC, STOOP WG, TSENG SC: Staining characteristics and antiviral activities of sulforhodamine B and lissamine green. Invest. Ophthalmol. Vis. Sci. (1994) 35 1046-1058.
8. FEENSTRA RP, TSENG SC: Comparison of fluorescein and rose Bengal staining. Ophthalmology (1992) 99:605-617.
9. KIM J, FOULKS GN: Evaluation of the effect of lissamine green and rose bengal on human corneal epithelial cells. Cornea (1999) 183:328-332.
10. MANNING FJ, WEHRLY SR, FOULKS GN: Patient tolerance and ocular surface staining characteristics of lissamine green versus rose bengal. Ophthalmology (1995) 102:1953-1957.
11. LEMP MA: Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. (1995) 21 221-232.
12. HUANG B, MIRZA MA, QAZI MA, PEPOSE JS: The effect of punctal occlusion on wavefront aberrations in dry eye patients after laser in situ keratomileusis. Am. J. Ophthalmol. (2004) 137 1):52-61.
13. SADE DE PAIVA C, PFLUGFELDER SC: Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am. J. Ophthalmol. (2004) 137(1):109-115.
14. PFLUGFELDER SC, JONES D, JI Z, AFONSO A, MONROY D: Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca. Curr. Eye Res. (1999) 19:201-211.
15. SONG XJ, LI DQ, FARLEY W, LUO LH et al.: Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest. Ophthalmol. Vis. Sci. (2003) 44(10):4223-4229.
16. PRABHASAWAT P, TSENG SC: Frequent association of delayed tear clearance in ocular irritation. Br. J. Ophthalmol. (1998) 82 666-675.
17. MARSH F, PFLUGFELDER SC: Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjö gren's syndrome. Ophthalmology (1999) 106:811-816.
18. SMALL DS, ACHEAMPONG A, REIS B et al.: Blood concentrations of cyclosporin a during long-term treatment with cyclosporin a ophthalmic emulsions in patients with moderate to severe dry eye disease. J. Ocul. Pharmacol. Ther. (2002) 18 5):411-418.
19. KUNERT KS, TISDALE AS, GIPSON IK: Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. Arch. Ophthalmol. (2002) 120 3):330-337.
20. HORI Y, SPURR-MICHAUD S, RUSSO CL, ARGUESO P, GIPSON IK: Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest. Ophthalmol. Vis. Sci. (2004) 45 1):112-117.
21. PERRY HD, DOSHI S, DONNENFELD ED et al.: Double masked randomized controlled study evaluating topical 0.05% cyclosporine A in the treatment of meibomian gland dysfunction (posterior blepharitis). Invest. Ophthalmol. Vis. Sci. (2003) 44:E-Abstract 1395.
22. JUMBLATT JE, JUMBLATT MM: Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp. Eye Res. (1998) 67:341-346.
23. ROCHA EM, WICKHAM LA, DA SILVEIRA LA et al.: Identification of androgen receptor protein and 5alpha-reductase mRNA in human ocular tissues. Br. J. Ophthalmol. (2000) 84:76-84.
24. CERMAK JM, KRENZER KL, SULLIVAN RM et al.: Is complete androgen insensitivity syndrome associated with alterations in the meibomian gland and ocular surface? Cornea (2003) 22 6):516-521.