Apoptosis in cervical cancer cells: Implications for adjunct anti-estrogen therapy for cervical cancer

Anticancer Research

Volumn 24, Issue 5 A, 2004, Pages 2649-2656

  Chen, Dazhi ^a   Carter, Timothy H ^a,b,c   Auborn, Karen J ^a,c  

^a N Shore Long Isl Jewish Res Inst ^*  (United States)

^b ST JOHN'S UNIVERSITY   (United States)

^c LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Cervical cancer; Estrogen; Indole 3 carbinol

Indexed keywords

3 INDOLEMETHANOL; ANTIESTROGEN; CISPLATIN; DNA; ESTROGEN; MITOMYCIN C; PACLITAXEL; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA DEGRADATION; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; ULTRAVIOLET B RADIATION; UTERINE CERVIX CANCER; WART VIRUS; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; FEMALE; HUMANS; INDOLES; MITOMYCIN; PACLITAXEL; ULTRAVIOLET RAYS; UTERINE CERVICAL NEOPLASMS;

EID: 6444227478     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Auborn KJ, Woodworth C, DiPaolo JA and Bradlow HL: The interaction between HPV infection and estrogen metabolism in cervical carcinogenesis. Int J Cancer 49: 867-869, 1991.
2. Newfield L, Bradlow HL, Sepkovic DW and Auborn K: Estrogen metabolism and the malignant potential of human papillomavirus immortalized keratinocytes. Proc Soc Expt Biol Med 217: 322-326, 1998.
3. Autier P, Coibon M, Huet F and Grivegnee AR: Transformation zone location and intraepithelial neoplasia of the cervix uteri. Br J Cancer 74; 448-490, 1996.
4. Schneider A, Meinhardt G, Kirchmayr R and Schneider V: Prevalence of human papillomavirus genomes in tissues from the lower genital tract as detected by molecular in situ hybridization. Int J Gynecol Pathol 10: 1-14, 1991.
5. Baken LA, Koutsky LA, Kuypers J, Kosorok MR, Lee SK, Kiviat NB and Holmes KK: Genital human papillomavirus infection among male and female sex partners: Prevalence and type-specific concordance. J Infect Dis 171: 429-432, 1995.
6. Arbeit JM, Howley PM and Hanahan D: Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice. Proc Natl Acad Sci USA 93: 2930-2935, 1996.
7. Sutherland RL, Prall OW, Watts CK and Musgrove EA: Estrogen and progestin regulation of cell cycle progression. J Mam Gland Biol Neoplasia 3: 63-72, 1998.
8. Anderson E, Clarke RB and Howell A: Estrogen responsiveness and control of normal human breast proliferation. J Mam Gland Biol Neoplasia 3: 23-35, 1998.
9. Telang NT, Suto A, Wong GY, Osborne MP and Bradlow HL: Induction by estrogen metabolite 16 alpha-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst 84: 634-638, 1992.
10. Swaneck GE and Fishman J: Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: Characterization and intranuclear localization. Proc Natl Acad Sci USA 85: 7831-7835, 1988.
11. Lustig RH, Mobbs CV, Pfaff DW and Fishman J: Temporal actions of 16 alpha-hydroxyestrone in rat: Comparisons of lordosis dynamics with other estrogen metabolites and between sexes. J Steroid Biochem Mol Biol 33: 417-421, 1989.
12. Mitrani-Rosenbaum S, Tsvieli R and Tur-Kaspa R: Oestrogen stimulates differential transcription of human papillomavirus type 16 in SiHa cervical cells. J Gen Virol 70: 2227-2232, 1989.
13. Yuan F, Chen DZ, Liu K, Sepkovic DW, Bradlow HL and Auborn K: Anti-estrogenic activities of indole-3-carbinol in cervical cells: Implication for prevention of cervical cancer. Anticancer Res 19: 1673-1680, 1999.
14. Werness BA, Levine AJ and Howley PM: Association of human papillomavirus type 16 and 18 E6 proteins with p53. Science 248: 76-79, 1990.
15. Munger K, Werness BA, Dyson N, Phelps WC, Harlow E and Howley PM: Complex formation of human papillomavirus E7 proteins with the retinoplastoma tumor supressor gene product. EMBO J 8: 4099-4105, 1989.
16. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124: 1-6, 1994.
17. McCall CA and Cohen JJ: Programmed cell death in terminally differentiating keratinocytes: role of endogenous nuclease. J Invest Dermatol 97: 111-114, 1991.
18. Marthinus J, Lawrence L and Seilberg M: Apoptosis in Pam212, an epidermal keratinocyte cell line: a possible role for bcl-2 in keratinocyte differentiation. Cell Growth Different 6: 239-250, 1995.
19. Bonner CD, Oldenburg NBE and Cidlowski JA: The role of DNA fragmentation in apoptosis. Trends Cell Biol 5: 21-26, 1995.
20. Lowe SW, Schmitt EM, Smith SW, Osborne BA and Jacks T: P53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849, 1993.
21. Lu X and Lane DP: Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes? Cell 75: 765-778, 1993.
22. Henseleit U, Zhang J, Wanner R, Haase I, Kolde G and Rosenbach T: Role of p53 in UVB-induced apoptosis in Human HaCat keratinocytes. J Invest Dermatol 109: 722-727, 1997.
23. Teixeira C, Reed JC and Pratt MAC: Estrogen promotes chemotheraputic drug resistance by a mechanism involving BCL-2 protooncogene expression in human breast cancer cells. Cancer Res 55: 3902-3907, 1995.
24. Huang Y, Ray S, Reed JC, Ibrado AM, Tang C, Nawabi A and Bhalla K: Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells. Breast Cane Res Treat 42: 73-81, 1997.
25. Kanda N and Watanabe S: 17beta-estrdiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression. J Invest Dermatol 727: 1500-1509. 2003.
26. Sribnick EA, Ray SK, Nowak MW, Li L and Baninik NL: 17beta-estrdiol attenuates glutamate-induced apoptosis and preserves electrophysiologic function in primary cortical neurons. J Neurosci Res 76: 688-696, 2004.
27. Hur J, Chesnes J, Coser KR, Lee RS, Geck P, Isselbacher KJ and Shioda T: The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed cancer cells and provokes apoptosis. Proc Natl Acad Sci USA 101: 2351-2356, 2004.
28. Guerin-Reverchon I, Chardonnet Y, Chignol MC and Thivolet J: A comparison of methods for the detection of human papillomavirus DNA by in situ hybridization with biotinylated probes on human carcinoma cell lines. Application to wart sections. J Imunolog Meth 123: 167-76, 1989.
29. Olah E, Csokay B, Prajda N, Kote-Jarai Z, Yeh YA and Weber G: Molecular mechanisms in the antiproliferative action of taxol and tiazofurin. Anticancer Res 16: 2469-2477, 1996.
30. Sekiguchi I, Suzuki M, Ohwada M and Sato I: Apoptosis as a criterion for sensitivity of uterine cervical adenocarcinoma to cisplatin. Oncology Rep 5: 1077-1078, 1998.
31. Leung SY, Jackson J, Miyake H, Burt H and Gleave ME: Polymeric micellar paclitaxel phosphorylates Bcl-2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors. Prostate 44: 156-63, 2000.
32. Tachibana S, Kawakami M, Nakao K, Tokitsu H, Morita T, Hashimoto T, Tokuhara T, Sasaki S, Ito Y and Otsuki Y: Preoperative bronchial arterial infusion of docetaxel for squamous cell carcinoma of the lung-clinical evaluation and correlation between anti-tumor effect and apoptosis. Jap J Cancer Chemother 27: 1029-33, 2000.
33. Chen D-Z, Qi M, Auborn KJ and Carter TH: Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cells and in murine HPV16-trangenic preneoplastic cervical epithelium. J Nutr 131: 3294-3302, 2001.
34. Ge X, Fares FA and Yannai S: Induction of apoptosis in MCF-7 cells by indol-3-carbinol is independent of p53 and bax. Anticancer Res 19: 3199-3203, 1999.
35. Katdare M, Osborne MP and Telang NT: Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals. Oncology Rep 5: 311-315, 1998.
36. Liu H, Wormke M, Safe SH and Bjeldanes LF: Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. J Natl Cancer Inst 86: 1758-1765, 1994.
37. Telang NT, Katdare M, Bradlow HL, Osborne MP and Fishman J: Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol. Proc Soc Expt Biol Med 216: 246-152, 1997.
38. Meng Q, Yuan F, Goldberg ID, Rosen, EM, Auborn KJ and Fan S: Indole-3-carbinol is a negative regulator of estrogen receptor-a signaling in human tumor cells. J Nutrition (in press).
39. Dong L, Wang W, Wang F, Stoner M, Reed JC, Harigai M, Samudio I, Kladde MP, Vyhlidal C and Safe S: Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells. J Biol Chem 274: 32099-32107, 1999.
40. Perillo B, Sasso A, Abbondanza C and Palumbo G: 17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence. Mol Cell Biol 20: 2890-2901, 2000.
41. Auborn K, Abramson A, Bradlow HL, Sepkovic D and Mullooly V: Estrogen metabolism and laryngeal papillomatosis: a pilot study on dietary prevention. Anticancer Res 18: 4569-4573, 1998.
42. Rosen CA, Woodson GE, Thompson JW, Hengesteg AP and Bradlow HL: Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 118: 810-815, 1998.
43. Bell MC, Crowley-Nowick P, Bradlow HL, Sepkovic DW, Schmidt-Grimminger D, Howell P, Mayeaux EJ, Tucker A, Turbat-Herrera EA and Mathis JM: Placebo controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 78: 123-129, 2000, doi 10/1006gyno.2000.5847.
44. Grose KR and Bjeldanes LF: Oligomerization of indole-3-carbinol in aqueous acid. Chem Res Toxicol 5: 188-93, 1992.
45. Broadbent TA and Broadbent HS: The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part I]. Current Medicinal Chem 5: 337-52, 1998.
46. Broadbent TA and Broadbent HS: The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol)and 3-(methoxymethyl)indole. [Part II], Current Medicinal Chem J: 469-91, 1998.