메뉴 건너뛰기




Volumn 5, Issue SUPPL. 1, 2004, Pages 22-25

Preclinical studies: How much can we rely on?

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CREATINE; CYCLOOXYGENASE 2 INHIBITOR; MINOCYCLINE; MUTANT PROTEIN; NEW DRUG; NIFEDIPINE; PROSTAGLANDIN; RILUZOLE; SUPEROXIDE DISMUTASE; VASCULOTROPIN;

EID: 6444223252     PISSN: 14660822     EISSN: None     Source Type: Journal    
DOI: 10.1080/17434470410020012     Document Type: Review
Times cited : (8)

References (19)
  • 1
    • 0028070257 scopus 로고
    • Rapid purification of embryonic rat motor neurons: An in vitro model for studying MND/ALS pathogenesis
    • Camu W, Henderson CE. Rapid purification of embryonic rat motor neurons: an in vitro model for studying MND/ALS pathogenesis. J Neurol Sci 1994; 124(suppl): 73-74.
    • (1994) J. Neurol. Sci. , vol.124 , Issue.SUPPL. , pp. 73-74
    • Camu, W.1    Henderson, C.E.2
  • 2
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein JD, Jin L, Dykes-Hoberg M et al. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 1993; 90: 6591-6595.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3
  • 3
    • 0029447538 scopus 로고
    • Neurotrophic factors as therapeutic agents in amyotrophic lateral sclerosis: Potential and pitfalls
    • Henderson CE. Neurotrophic factors as therapeutic agents in amyotrophic lateral sclerosis: potential and pitfalls. Adv Neurol 1995; 68: 235-240.
    • (1995) Adv. Neurol. , vol.68 , pp. 235-240
    • Henderson, C.E.1
  • 4
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Wong PC, Pardo CA, Borchelt DR et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995; 14: 1105-1116.
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1    Pardo, C.A.2    Borchelt, D.R.3
  • 5
    • 0031051485 scopus 로고    scopus 로고
    • ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
    • Bruijn LI, Becher MW, Lee MK et al. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 1997; 18: 327-338.
    • (1997) Neuron , vol.18 , pp. 327-338
    • Bruijn, L.I.1    Becher, M.W.2    Lee, M.K.3
  • 6
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation
    • Gurney ME, Pu H, Chiu AY et al. Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation. Science 1994; 264: 1772-1775.
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1    Pu, H.2    Chiu, A.Y.3
  • 7
    • 0037022339 scopus 로고    scopus 로고
    • Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant mediated amyotrophic lateral sclerosis (ALS)
    • Howland DS, Liu J, She Y et al. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci USA 2002; 99: 1604-1609.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1604-1609
    • Howland, D.S.1    Liu, J.2    She, Y.3
  • 8
    • 0035516124 scopus 로고    scopus 로고
    • From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
    • Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2001; 2: 806-819.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 806-819
    • Cleveland, D.W.1    Rothstein, J.D.2
  • 9
    • 0034651102 scopus 로고    scopus 로고
    • Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motor neuron degeneration
    • Gong YH, Parsadanian AS, Andreeva A et al. Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motor neuron degeneration. J Neurosci 2000; 20: 660-665.
    • (2000) J. Neurosci. , vol.20 , pp. 660-665
    • Gong, Y.H.1    Parsadanian, A.S.2    Andreeva, A.3
  • 10
    • 0037096354 scopus 로고    scopus 로고
    • Accumulation of SOD1 mutants in postnatal motor neurons does not cause motor neuron pathology or motor neuron disease
    • Lino MM, Schneider C, Caroni P. Accumulation of SOD1 mutants in postnatal motor neurons does not cause motor neuron pathology or motor neuron disease. J Neurosci 2002; 22: 4825-4832.
    • (2002) J. Neurosci. , vol.22 , pp. 4825-4832
    • Lino, M.M.1    Schneider, C.2    Caroni, P.3
  • 11
    • 0037068836 scopus 로고    scopus 로고
    • Motor neuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations
    • Raoul C, Estevez AG, Nishimune H et al. Motor neuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations. Neuron 2002; 35: 1067-1083.
    • (2002) Neuron , vol.35 , pp. 1067-1083
    • Raoul, C.1    Estevez, A.G.2    Nishimune, H.3
  • 12
    • 0034660457 scopus 로고    scopus 로고
    • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease
    • Ferrante RJ, Andreassen OA, Jenkins BG et al. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci 2000; 20: 4389-4397.
    • (2000) J. Neurosci. , vol.20 , pp. 4389-4397
    • Ferrante, R.J.1    Andreassen, O.A.2    Jenkins, B.G.3
  • 13
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • Gurney ME, Cutting FB, Zhai P et al. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 1996; 39: 147-157.
    • (1996) Ann. Neurol. , vol.39 , pp. 147-157
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3
  • 14
    • 0037379650 scopus 로고    scopus 로고
    • A randomized sequential trial of creatine monohydrate in amyotrophic lateral sclerosis
    • Groeneveld GJ, Veldink JH, van der Tweel I. A randomized sequential trial of creatine monohydrate in amyotrophic lateral sclerosis. Ann Neurol 2003; 53: 437-445.
    • (2003) Ann. Neurol. , vol.53 , pp. 437-445
    • Groeneveld, G.J.1    Veldink, J.H.2    van der Tweel, I.3
  • 15
    • 0037381851 scopus 로고    scopus 로고
    • An efficient three-drug cocktail for motor neuron disease induced by mutant superoxide dismutase
    • Kriz J, Gowing G, Julien J. An efficient three-drug cocktail for motor neuron disease induced by mutant superoxide dismutase. Ann Neurol 2003; 53: 429-436.
    • (2003) Ann. Neurol. , vol.53 , pp. 429-436
    • Kriz, J.1    Gowing, G.2    Julien, J.3
  • 16
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington's disease
    • Chen M, Ona VO, Li M et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington's disease. Nat Med 2000; 6: 797-801.
    • (2000) Nat. Med. , vol.6 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3
  • 17
    • 0036406903 scopus 로고    scopus 로고
    • Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
    • Kriz J, Nguyen MD, Julien JP. Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2002; 10: 268-278.
    • (2002) Neurobiol. Dis. , vol.10 , pp. 268-278
    • Kriz, J.1    Nguyen, M.D.2    Julien, J.P.3
  • 18
    • 0037067009 scopus 로고    scopus 로고
    • Minocycline delays disease onset and mortality in a transgenic model of ALS
    • Van den BL, Tilkin P, Lemmens G et al. Minocycline delays disease onset and mortality in a transgenic model of ALS. Neuroreport 2002; 13: 1067-1070.
    • (2002) Neuroreport , vol.13 , pp. 1067-1070
    • Van den, B.L.1    Tilkin, P.2    Lemmens, G.3
  • 19
    • 0036829010 scopus 로고    scopus 로고
    • From chemical to drug: Neurodegeneration drug screening and the ethics of clinical trials
    • Heemskerk J, Tobin AJ, Ravina B. From chemical to drug: neurodegeneration drug screening and the ethics of clinical trials. Nat Neurosci 2002; 5(suppl): 1027-1029.
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1027-1029
    • Heemskerk, J.1    Tobin, A.J.2    Ravina, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.