Acute changes in intermediary metabolism in cerebellum and contralateral hemisphere following middle cerebral artery occlusion in rat

Journal of Neurochemistry

Volumn 109, Issue SUPPL. 1, 2009, Pages 174-181

  Håberg, Asta K ^a,b,c   Qu, Hong ^c   Sonnewald, Ursula ^c  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

1,2 13C acetate; 1 13C glucose; Diaschisis; GABA; Glutamate; Glutamine; Ischemia; Pyruvate carboxylase; Pyruvate dehydrogenase; TCA cycle

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ACETIC ACID; BRAIN EXTRACT; CARBON 13; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; NEUROTRANSMITTER; TRICARBOXYLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTE; BRAIN BLOOD FLOW; BRAIN METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; CELL INTERACTION; CITRIC ACID CYCLE; CONFERENCE PAPER; CYTOARCHITECTURE; EX VIVO STUDY; FRONTAL LOBE; HEMISPHERE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT;

ACETATES; ACUTE DISEASE; AMINO ACIDS; ANIMALS; ARTERIAL OCCLUSIVE DISEASES; ASTROCYTES; BRAIN CHEMISTRY; BRAIN ISCHEMIA; CEREBELLUM; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGLUCOSE; ELECTROPHYSIOLOGY; FUNCTIONAL LATERALITY; GLUCOSE; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE CEREBRAL ARTERY; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR;

RATTUS;

EID: 64349088771     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05940.x     Document Type: Conference Paper

References (49)

1. Askim T., Indredavik B., Vangberg T. R. Håberg A. (2009). Motor network changes associated with successful motor skill relearning in patients with acute ischemic stroke. A longitudinal functional MRI study. Neurorehabil. Neural Repair. 23, 295 304.
2. Badar-Goffer R. S., Ben-Yoseph O., Bachelard H. S. Morris P. G. (1992) Neuronal-glial metabolism under depolarizing conditions. A 13C-n.m.r. study. Biochem. J. 282, 225 230.
3. Barbaresi P., Fabri M., Conti F. Manzoni T. (1987) D-[3H]aspartate retrograde labelling of callosal and association neurones of somatosensory areas I and II of cats. J. Comp. Neurol. 263, 159 178.
4. Buchkremer-Ratzmann I., August M., Hagemann G. Witte O. W. (1996) Electrophysiological transcortical diaschisis after cortical photothrombosis in rat brain. Stroke 27, 1105 1109.
5. Bury S. D. Jones T. A. (2004) Facilitation of motor skill learning by callosal denervation or forced forelimb use in adult rats. Behav. Brain Res. 150, 43 53.
6. Bury S. D., Adkins D. L., Ishida J. T., Kotzer C. M., Eichhorn A. C. Jones T. A. (2000) Denervation facilitates neuronal growth in the motor cortex of rats in the presence of behavioral demand. Neurosci. Lett. 287, 85 88.
7. Carretta D., Sbriccoli A., Santarelli M., Pinto F., Granato A. Minciacchi D. (1996) Crossed thalamo-cortical and cortico-thalamic projections in adult mice. Neurosci. Lett. 204, 69 72.
8. Chowdhury G. M. I., Patel A. B., Mason G. F., Rothman D. L. Behar K. L. (2007) Glutamate and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development. J. Cereb. Blood Flow Metab. 27, 1895 1907.
9. Conti F. Manzoni T. (1994) The neurotransmitters and postsynaptic actions of callosally projecting neurons. Behav. Brain Res. 64, 37 53.
10. Enager P., Gold L. Lauritzen M. (2004) Impaired neurovascular coupling by transhemispheric diaschisis in rat cerebral cortex. J. Cereb. Blood Flow Metab. 24, 713 719.
11. Fabri M. Manzoni T. (2004) Glutamic acid decarboxylase immunoreactivity in callosal projecting neurons of cat and rat somatic sensory areas. Neurosci. 123, 557 566.
12. Ginsberg M. D., Reivich M., Giandomenico A. Greenberg J. H. (1977) Local glucose utilization in acute focal cerebral ischemia: local dysmetabolism and diaschisis. Neurology 27, 1042 1048.
13. Ginsberg M. D., Castella Y., Dietrich W. D., Watson B. D. Busto R. (1989) Acute thrombotic infarction suppression metabolic activaton of ipsilateral somatosensory cortex: evidence for functional diaschisis. J. Cereb. Blood Flow Metab. 9, 329 341.
14. Gold L. Lauritzen M. (2002) Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function. Proc. Natl Acad. Sci. USA 99, 7699 7704.
15. 13C NMR spectroscopy: A novel approach to the study of MCA occlusion in rat. J. Cereb. Blood Flow Metab. 18, 1223 1232.
16. Håberg A., Qu H., Sæther O., Haraldseth O., Unsgård G. Sonnewald U. (2001) Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of MCAO in the rat. The role of astrocytes in neuronal survival. J. Cereb. Blood Flow Metab. 21, 1451 1463.
17. Håberg A., Qu H. Sonnewald U. (2006) Glutamate and GABA metabolism in transient and permanent middle cerebral artery occlusion in rat; importance of astrocytes for neuronal survival. Neurochem. Int. 48, 531 540.
18. Håberg A., Qu H., Hjelstuen M. H. Sonnewald U. (2007) Effect of the pyrrolopyrimidine lipid peroxidation inhibitor U-101033E on neuronal and astrocytic metabolism and infarct volume in rats with transient middle cerebral artery occlusion. Neurochem. Int. 50, 932 940.
19. Hassel B., Bachelard H., Jones P., Fonnum F. Sonnewald U. (1997) Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. J. Cereb. Blood Flow Metab. 17, 1230 1238.
20. Hossmann K. A., Mies G., Paschen W., Csiba L., Bodsch W., Rapin J. R., Le Poncin-Lafitte M. Takahashi K. (1985) Multiparametric imaging of blood flow and metabolism after middle cerebral artery occlusion in cats. J. Cereb. Blood Flow Metab. 5, 97 107.
21. James J. H. Fischer J. E. (1981) Transport of neutral amino acids at the blood-brain-barrier. Pharmacology 22, 1 7.
22. Joashi U. C., Greenwood K., Taylor D. L., Kozma M., Mazarakis N. D., Edwards A. D. Mehmet H. (1999) Poly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain. Eur. J. Neurosci. 11, 91 100.
23. Johansen-Berg H., Rushworth M. F., Bogdanovic M. D., Kischka U., Wimalaratna S. Matthews P. M. (2002) The role of ipsilateral premotor cortex in hand movement after stroke. Proc. Natl Acad. Sci. USA 99, 14518 14523.
24. Jones T. A., Chu C. J., Grande L. A. Gregory A. D. (1999) Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J. Neurosci. 19, 10153 10163.
25. Kempinsky W. H. (1958) Experimental study of distant effects of acute focal brain injury; a study of diaschisis. AMA Arch. Neurol. Psychiatry 79, 376 389.
26. Kotwica Z., Persson L. Thuomas K. A. (1989) The effect of brain edam on intracranial pressure in focal cerebral ischemia. An experimental study in rat using magnetic resonance imaging. Zentralbla Neurochir. 50, 68 71.
27. Longa E. Z., Weinstein P. R. Cummins R. (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20, 84 91.
28. Mason G. F., Behar K. L., Rothman D. L. Shulman R. G. (1992) NMR determination of intracerebral glucose concentration and transport kinetics in rat brain. J. Cereb. Blood Flow Metab. 12, 448 455.
29. Matsumoto A., Busto R., Kogure K., Scheinberg P. Reinmuth O. (1974) Bilateral brain edema following unilateral cold injury. Trans. AM Neurol. Assoc. 99, 229 231.
30. McKenna M. C., Sonnewald U., Huang X., Stevenson J. Zielke H. R. (1996) Exogenous glutamate concentrations regulates the metabolic fate of glutamate in astrocytes. J. Neurochem. 66, 386 393.
31. Meyer J. S., Obara K. Muramatsu K. (1993) Diaschisis. Neurol Res. 15, 362 366.
32. Molinari M., Minciacchi D., Bentivoglio M. Macchi G. (1985) Efferent fibers from the motor cortex terminate bilaterally in the thalamus of rats and cats. Exp. Brain Res. 57, 305 312.
33. von Monakow C. (1914). Lokalisation im Gehirn und Funktionelle Störungen Induziert Durch Kortikale Läsionen. Wiesbaden, Germany, Bergmann, J.F.
34. Navarro D., Zwingmann C. Butterworth R. F. (2008) Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamin-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy. J. Neurochem. 106, 603 612.
35. Olstad E., Qu H. Sonnewald U. (2007) Glutamate is preferred over glutamine for intermediary metabolism in cultured cerebellar neurons. J. Cereb. Blood Flow Metab. 27, 811 820.
36. Oz G., Berkich D. A., Henry P. G., Xu Y., LaNoue K., Hutson S. M. Gruetter R. (2004) Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity. J. Neurosci. 15, 11273 11279.
37. Pascual J. M., Carceller F., Roda J. M. Cerdán S. (1998) Glutamate, glutamine and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats. Stroke 29, 1048 1057.
38. 13C]D-glucose. MRM 41, 1077 1083.
39. Reglodi S., Somogyvari-Vigh A., Maderdrut J. L., Vigh S. Arimura A. (2000) Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occlusion in the rat. Exp. Neurol. 163, 399 407.
40. Richards E. M., Fiskum G., Rosenthal R. E., Hopkins I. Mckenna M. C. (2007) Hypoxic reperfusion after global ischemia decreases hippocampal energy metabolism. Stroke 38, 1578 1584.
41. Seitz R. J., Azari N. P., Knorr U., Binkofski F., Herzog H. Freund H. J. (1999) The role of diaschisis in stroke recovery. Stroke 30, 1844 1850.
42. 13C]glucose metabolism. J. Neurochem. 61, 315 323.
43. 13C NMR. Proc. Natl Acad. Sci. USA 14, 8235 8240.
44. Shinohara Y., Ohsuga H., Ohsuga S., Takizawa S. Haida M. (1990) Routed protein migration after protein extravasation and water leakage caused by cold injury. Acta Neurochir. Suppl. (Wien.) 51, 90 92.
45. 13C NMR studies. J. Neurochem. 67, 1711 1717.
46. Stroemer R. P., Kent T. A. Hulsebosch C. E. (1995) Neocortical sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rat. Stroke 26, 2135 2144.
47. Whishaw I. Q. (2000) Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat. Neuropharmacology 39, 788 805.
48. Wilson C. J. (1987) Morphology and synaptic connections of crossed corticostriatal neurons in the rat. J. Comp. Neurol. 263, 567 580.
49. Wu H. S., Sugihara I. Shinoda Y. (1999) Projection patterns of single mossy fibers originating from the lateral reticular nucleus in the rat cerebellar cortex and nuclei. J. Comp. Neurol. 1411, 97 118.