Role of microsomal glutathione transferase 1 in the mechanism-based biotransformation of glyceryl trinitrate in LLC-PK1 cells

Biochemical Pharmacology

Volumn 77, Issue 11, 2009, Pages 1702-1708

  Ji, Yanbin ^a   Anderson, Diane J ^a   Bennett, Brian M ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Biotransformation; cGMP; Glyceryl trinitrate; Microsomal glutathione transferase 1; Soluble guanylyl cyclase

Indexed keywords

CYCLIC GMP; DRUG METABOLITE; GLUTATHIONE TRANSFERASE; GLYCEROL 1,3 DINITRATE; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; MICROSOME ENZYME; MICROSOME GLUTATHIONE TRANSFERASE 1; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG TRANSFORMATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOBLOTTING; MICROSOME; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WILD TYPE;

ANIMALS; BIOTRANSFORMATION; CELL DIVISION; CYCLIC GMP; GLUTAMINE; GLUTATHIONE TRANSFERASE; INSULIN; LLC-PK1 CELLS; MICE; MICROSCOPY, CONFOCAL; MICROSOMES; NADPH-FERRIHEMOPROTEIN REDUCTASE; NITROGLYCERIN; SWINE;

EID: 64249110056     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.02.022     Document Type: Article

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