Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: A case report

Acta Paediatrica, International Journal of Paediatrics

Volumn 98, Issue 5, 2009, Pages 903-905

  Zaffanello, Marco ^a   Brugnara, Milena ^a   Angeli, Silvia ^a   Cuzzolin, Laura ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

Acetaminophen; Ibuprofen; Kidney failure; Liver disease; Pyrexia

Indexed keywords

CEFTRIAXONE; DIAZEPAM; FUROSEMIDE; IBUPROFEN; NIFEDIPINE; ORAL REHYDRATION SOLUTION; PARACETAMOL; VERAPAMIL;

ACUTE KIDNEY FAILURE; ANAMNESIS; ARTICLE; CASE REPORT; CHILD; CHOLESTATIC HEPATITIS; CLINICAL ASSESSMENT; DEHYDRATION; ECHOGRAPHY; ELECTROENCEPHALOGRAM; FEBRILE CONVULSION; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; LABORATORY TEST; PHYSICAL EXAMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL; URINALYSIS; VOMITING;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; CHILD, PRESCHOOL; CHOLESTASIS; DRUG THERAPY, COMBINATION; FEMALE; FEVER; HEPATITIS, TOXIC; HUMANS; IBUPROFEN; KIDNEY FAILURE, ACUTE;

EID: 64149108265     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2008.01209.x     Document Type: Article

References (15)

1. Squires RH Jr., Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr 2006 148 : 652 8.
2. American academy of pediatrics. Committee on drugs. Acetaminophen toxicity in children. Pediatrics 2001 108 : 1020 4.
3. Martínez C, García-Martín E, Blanco G, Gamito FJ, Ladero JM, Agúndez JA. The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects. Br J Clin Pharmacol 2005 59 : 62 9.
4. Perrott DA, Piira T, Goodenough B, Champion D. Efficacy and safety of acetaminophen vs. ibuprofen for treating children's pain or fever: a meta-analysis. Arch Pediatr Adolesc Med 2004 158 : 521 6.
5. Moghal NE, Hegde S, Eastham KM. Ibuprofen and acute renal failure in a toddler. Arch Dis Child 2004 89 : 276 7.
6. Erdeve O, Sarici SU, Sari E, Gok F. Oral-ibuprofen-induced acute renal failure in a preterm infant. Pediatr Nephrol 2008 23 : 1565 7.
7. Ulinski T, Guigonis V, Dunan O, Bensman A. Acute renal failure after treatment with non-steroidal anti-inflammatory drugs. Eur J Pediatr 2004 163 : 148 50.
8. Whelton A. Nephrotoxicity of non-steroidal anti-inflammatory drugs: physiologic foundations and clinical implications. Am J Med 1999 106 : 13S 24S.
9. Smith DW, Isakson G, Frankel LR, Kerner JAJ. Hepatic failure following ingestion of multiple doses of acetaminophen in a young child. J Pediatr Gastroenterol Nutr 1996 5 : 822 5.
10. Grieco A, Miele L, Forgione A, Ragazzoni E, Vecchio FM, Gasbarrini G. Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activity. J Clin Pharm Ther 2008 33 : 315 20.
11. Mayoral CE, Marino RV, Rosenfeld W, Greensher J. Alternating antipyretics: is this an alternative? Pediatrics 2000 105 : 1009 12.
12. Kramer LC, Richards PA, Thompson AM, Harper DP, Fairchok MP. Alternating antipyretics: antipyretic efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children. Clin Pediatr (Phila) 2008 47 : 907 11.
13. Rivera-Penera T, Gugig R, Davis J, McDiarmid S, Vargas J, Rosenthal P, et al. Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity. J Pediatr 1997 130 : 300 4.
14. Pérez-Gutthann S, García-Rodríguez LA, Duque-Oliart A, Varas-Lorenzo C. Low-dose diclofenac, naproxen, and ibuprofen cohort study. Pharmacotherapy 1999 19 : 854 9.
15. Moghal NE, Hulton SA, Milford DV. Care in the use of ibuprofen as an antipyretic in children. Clin Nephrol 1998 49 : 293 5.