Alternating antipyretics: Antipyretic efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children

Clinical Pediatrics

Volumn 47, Issue 9, 2008, Pages 907-911

  Kramer, Lynne C ^a   Richards, Peaches A ^b   Thompson, Amy M ^a   Harper, David P ^c   Fairchok, Mary P ^a  

^a MADIGAN ARMY MEDICAL CENTER   (United States)

^b Weed Army Community Hospital   (United States)

^c WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

Acetaminophen; Fever; Ibuprofen; Pediatric

Indexed keywords

ANTIBIOTIC AGENT; CHILDREN MOTRIN; CHILDREN TYLENOL; DIPHENHYDRAMINE; GUAIFENESIN; IBUPROFEN; PARACETAMOL; PLACEBO; UNCLASSIFIED DRUG;

ANTIPYRETIC ACTIVITY; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECREASED APPETITE; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; EPIGASTRIC PAIN; FEMALE; FEVER; FLATULENCE; HEADACHE; HUMAN; INFANT; INSOMNIA; MALE; MONOTHERAPY; NAUSEA; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; TEMPERATURE MEASUREMENT; VOMITING;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; FEVER; HUMANS; IBUPROFEN; INFANT; MALE; PLACEBOS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 53249132752     PISSN: 00099228     EISSN: None     Source Type: Journal    
DOI: 10.1177/0009922808319967     Document Type: Article

References (23)

1. Schmitt BD Fever phobia: misconceptions of parents about fevers. Am J Dis Child. 1980 ; 134: 176-180.
2. Crocetti M., Moghbeli M., Serwint J. Fever phobia revisited: have parental misconceptions about fever changed in 20 years? Pediatrics. 2001 ; 107: 1241-1246.
3. Kramer MS, Naimark L., Leduc DG Parental fever phobia and its correlates. Pediatrics. 1985 ; 75: 1110-1113.
4. May A., Bauchner H. Fever phobia: the pediatrician's contribution. Pediatrics. 1992: 90: 851-854.
5. Mayoral CE, Marino RV, Rosenfeld W., Greensher J. Alternating antipyretics: is this an alternative ? Pediatrics. 2000 ; 105: 1009-1012.
6. Lesko SM, Mitchell AA The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics. 1999 ; 104: e39.
7. Lesko SM, Mitchell AA Renal function after short-term ibuprofen use in infants and children. Pediatrics. 1997 ; 100: 954-957.
8. Lesko SM, Mitchell AA An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized clinical trial. JAMA. 1995 ; 273: 929-933.
9. Perrott DA, Piira T., Goodenough B., Champion D. Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. Arch Pediatr Adolesc Med. 2004 ; 158: 521-526.
10. Diez DD, Burgos RB, Garrido GG, Ballester SA, Moreno CE Use of alternating antipyretics in the treatment of fever in Spain. An Esp Pediatr. 2001 ; 55: 503-510.
11. Saphyakhajon P., Greene G. Alternating acetaminophen and ibuprofen in children may cause parental confusion and is dangerous. Arch Pediatr Adolesc Med. 2006 ; 160: 757.
12. Stan B. Ibuprofen and/or acetaminophen: what price for "euthermia "? J Pediatr. 1997 ; 131: 332-333.
13. Mofenson HC, McFee R., Caraccio T., Greensher J. Combined antipyretic therapy: another potential source of chronic acetaminophen toxicity. J Pediatr. 1998 ; 133: 712-713.
14. Del Vecchio MT, Sundel ER Alternating antipyretic: is this an alternative? [comment] Pediatrics. 2001 ; 108: 1236-1237.
15. Nabulsi MM, Tamim H., Mahfoud Z., et al. Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study. BMC Med. 2006 ; 4: 4.
16. Sarrell EM, Wielunsky E., Cohen HA Antipyretic treatment in young children with fever: acetaminophen, ibuprofen or both alternating in a randomized, double-blind study. Arch Pediatr Adolesc Med. 2006 ; 160: 197-202.
17. Schmitt BD Myths and facts about fever, parental education handout [patient handout on the Internet]. MDconsult, McKesson Health Solutions; 2003. http://home.mdconsult.com/das/patient/view/64248382-2/10002/13257.html/ top?sid=533389680&SEQNO=1.
18. Lal A., Gomber S., Talukdar B. Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol. Indian J Pediatr. 2000 ; 67: 865-870.
19. Walson PD, Galletta G., Chomilo F., Braden NJ, Sawyer LA, Scheinbaum ML Comparison of multidose ibuprofen and acetaminophen therapy in febrile children. Am J Dis Child. 1992 ; 146: 626-636.
20. Ulinski T., Guigonis V., Dunan O., Bensman A. Acute renal failure after treatment with non-steroidal antiinflammatory drugs. Eur J Pediatr. 2004 ; 163: 148-150.
21. Bilenko N., Tessler H., Okbe R., Press J., Gorodischer R. Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clin Ther. 2006 ; 28: 783-793.
22. Li SF, Lacher B., Crain EF Acetaminophen and ibuprofen dosing by parents. Pediatr Emerg Care. 2000 ; 16: 394-397.
23. Casey R., McMahon F., McCormick MC, et al. Fever therapy: an educational intervention for parents. Pediatrics. 1984 ; 73: 600-605.