Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 13, 2009, Pages 1344-1351

  Muetzelburg, M V ^a   Hofmann, F ^a   Just, I ^a   Pich, A ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

iTRAQ; LC MALDI; Multidimensional chromatography; Neuronal cells; SHSY 5Y cells

Indexed keywords

ITRAQ; LC-MALDI; MULTIDIMENSIONAL CHROMATOGRAPHY; NEURONAL CELLS; SHSY-5Y CELLS;

AMINES; BIOMARKERS; CELL CULTURE; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DIAGNOSIS; HOLMIUM; MASS SPECTROMETRY; PEPTIDES;

CELLS;

BIOLOGICAL MARKER; CELL PROTEIN; EXOENZYME C3; REAGENT; STABLE ISOTOPE;

AMINO ACID SEQUENCE; ARTICLE; CLOSTRIDIUM BOTULINUM; DEVICE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOBARIC TAGGING FOR RELATIVE AND ABSOLUTE QUANTIFICATION; LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NERVE CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; QUANTITATIVE ASSAY; SCREENING TEST; TANDEM MASS SPECTROMETRY;

ADP RIBOSE TRANSFERASES; BIOLOGICAL MARKERS; BOTULINUM TOXINS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOSTRIDIUM BOTULINUM; HUMANS; NEURONS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

CLOSTRIDIUM BOTULINUM;

EID: 64149099646     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.12.005     Document Type: Article

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