Overinterpretation of clinical applicability in molecular diagnostic research

Clinical Chemistry

Volumn 55, Issue 4, 2009, Pages 786-794

  Lumbreras, Blanca ^a   Parker, Lucy A ^a   Porta, Miquel ^b   Pollán, Marina ^c   Ioannidis, John P A ^d   Hernández Aguado, Ildefonso ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^c CARLOS III INSTITUTE OF HEALTH   (Spain)

^d UNIVERSITY OF IOANNINA   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL EVALUATION; CLINICAL RESEARCH; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; EXPECTATION; LABORATORY; METHODOLOGY; POPULATION; RISK; SCIENTIFIC LITERATURE; HUMAN; META ANALYSIS; ONLINE SYSTEM; STATISTICS;

HUMANS; MOLECULAR DIAGNOSTIC TECHNIQUES; ONLINE SYSTEMS; RESEARCH DESIGN;

EID: 64149088958     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2008.121517     Document Type: Article

References (26)

1. Zolg W. The proteomic search for diagnostic biomarkers: lost in translation? Mol Cell Proteom- ics 2006;5:1720-6.
2. Ioannidis JP. Molecular bias. Eur J Epidemiol 2005;20:739-45.
3. Check E. Proteomics and cancer: running before we can walk? Nature 2004;429:496-7.
4. Porta M, Hernández-Aguado I, Lumbreras B, Crous- Bou M. «Omics' research, monetization of intellec- tual property and fragmentation of knowledge: can clinical epidemiology strengthen integrative re- search? J Clin Epidemiol 2007;60:1220-5.
5. Hernández-Aguado I. The winding road towards evidence based diagnoses. J Epidemiol Commu- nity Health 2002;56:323-5.
6. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, et al. The STARD state- ment for reporting studies of diagnostic accuracy: explanation and elaboration. Clin Chem 2003;49: 7-18.
7. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 2003;3:25.
8. Feinstein AR. Clinical epidemiology: the architec- ture of clinical research. Philadelphia: WB Saunders; 1985. 812 p.
9. Sackett DL, Haynes RB. Evidence base of clinical diagnosis: the architecture of diagnostic research. BMJ 2002;324:539-41.
10. Pepe MS, Etzioni R, Feng Z, Potter JD, Thompson ML, Thornquist M, et al. Phases of biomarker development for early detection of cancer. J Natl Cancer Inst 2001;93:1054-61.
11. Dobbin KK, Beer DG, Meyerson M, Yeatman TJ, Gerald WL, Jacobson JW, et al. Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin Cancer Res 2005;11:565-72.
12. Storms V, Baele M, Coopman R, Willems A, de Baere T, Haesebrouck F, et al. Study of the intra- and interlaboratory reproducibility of partial sin- gle base C-sequencing of the 16S rRNA gene and its applicability for the identification of members of the genus Streptococcus. Syst Appl Microbiol 2002;25:52-9.
13. Ransohoff DF. Rules of evidence for cancer molecular-marker discovery and validation. Nat Rev Cancer 2004;4:309-14.
14. Rutjes AW, Reitsma JB, Vandenbroucke JP, Glas AS, Bossuyt PM. Case-control and two-gate de- signs in diagnostic accuracy studies. Clin Chem 2005;51:1335-41.
15. Ioannidis JP. Is molecular profiling ready for use in clinical decision making? Oncologist 2007;12: 301-11.
16. Reid MC, Lachs MS, Feinstein AR. Use of meth- odological standards in diagnostic test research. Getting better but still not good. JAMA 1995;274: 645-51.
17. Lijmer JG, Mol BW, Heisterkamp S, Bonsel GJ, Prins MH, van der Meulen JH, et al. Empirical evidence of design-related bias in studies of di- agnostic tests. JAMA 1999;282:1061-6.
18. Lumbreras-Lacarra B, Ramos-Rincon JM, Hernández-Aguado I. Methodology in diagnostic laboratory test research in clinical chemistry and clinical chemistry and laboratory medicine. Clin Chem 2004;50:530-6.
19. Yesupriya A, Evangelou E, Kavvoura FK, Patso- poulos NA, Clyne M, Walsh MC, et al. Reporting of human genome epidemiology (HuGE) associa- tion studies: an empirical assessment. BMC Med Res Methodol 2008;8:31.
20. Kyzas PA, Denaxa-Kyza D, Ioannidis JP. Almost all articles on cancer prognostic markers report sta- tistically significant results. Eur J Cancer 2007;43: 2559-79.
21. van't Veer LJ, Bernards R. Enabling personalized cancer medicine through analysis of gene- expression patterns. Nature 2008;452:564-70.
22. Van den Bruel A, Aertgeerts B, Buntinx F. Results of diagnostic accuracy studies are not always validated. J Clin Epidemiol 2006;59:559-66.
23. Kaptchuk TJ. Effect of interpretive bias on re- search evidence. BMJ 2003;326:1453-5.
24. Porta M, ed. A dictionary of epidemiology. 5th ed. New York: Oxford University Press; 2008. Interpretive bias; p. 133.
25. Veenstra TD. Global and targeted quantitative proteomics for biomarker discovery. J Chro- matogr B Analyt Technol Biomed Life Sci 2007; 847:3-11.
26. Lumbreras B, Porta M, Hernández-Aguado I. As- sessing the social meaning, value and implica- tions of research in genomics. J Epidemiol Com- munity Health 2007;61:755-6.