Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 9, Issue 2, 2008, Pages 221-228

  Shamji, Mohammed F ^a,c   Jing, Liufang ^a   Chen, Jun ^a   Hwang, Priscilla ^a   Ghodsizadeh, Odelia ^a   Friedman, Allan H ^b   Richardson, William J ^b   Setton, Lori A ^a,b,d  

^a Duke University   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF OTTAWA   (Canada)

^d DUKE UNIVERSITY   (United States)

Author keywords

Dorsal root ganglion; Elastin like polypeptide; Inflammation; Rat; Soluble tumor necrosis factor receptor; Tumor necrosis factor

Indexed keywords

ELASTIN; GLUTAMIC ACID; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; LACTIC ACID; PROSTAGLANDIN E2; PYRUVIC ACID; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 2; CYTOKINE; DRUG CARRIER; ENDOTOXIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CYTOKINE RELEASE; EXPLANT; MALE; METABOLIC STRESS; METABOLITE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHENOTYPE; RAT; SPINAL GANGLION; STIMULATION; SUPERNATANT; TEMPERATURE; ANIMAL; IN VITRO STUDY; RADICULOPATHY; SPRAGUE DAWLEY RAT;

ANIMALS; CYTOKINES; DINOPROSTONE; DRUG CARRIERS; ENDOTOXINS; GANGLIA, SPINAL; MALE; RADICULOPATHY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TUMOR NECROSIS FACTOR-ALPHA;

EID: 52449127481     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/SPI/2008/9/8/221     Document Type: Article

References (53)

1. Aderka D, Sorkine P, Abu-Abid S, Lev D, Setton A, Cope AP, et al: Shedding kinetics of soluble tumor necrosis factor (TNF) receptors after systemic TNF leaking during isolated limb perfusion. Relevance to the pathophysiology of septic shock. J Clin Invest 101:650-659, 1998
2. Barbara JA, Smith WB, Gamble JR, Van Ostade X, Vandenabeele P, Tavernier J, et al: Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants. Embo J 13:843-850, 1994 (Pubitemid 2032538)
3. Betre H, Liu W, Zalutsky MR, Chilkoti A, Kraus VB, Setton LA: A thermally responsive biopolymer for intra-articular drug delivery. J Control Release 115:175-182, 2006
4. Bidwell GL III, Raucher D: Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy. Mol Cancer Ther 4:1076-1085, 2005
5. Brisby H, Olmarker K, Larsson K, Nutu M, Rydevik B: Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J 11:62-66, 2002 (Pubitemid 34169899)
6. Chen PC, DuBois GC, Chen MJ: Mapping the domain(s) critical for the binding of human tumor necrosis factor-alpha to its two receptors. J Biol Chem 270:2874-2878, 1995
7. Chilkoti A, Dreher MR, Meyer DE: Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Adv Drug Deliv Rev 54:1093-1111, 2002
8. Chow DC, Dreher MR, Trabbic-Carlson K, Chilkoti A: Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli. Biotechnol Prog 22:638-646, 2006 (Pubitemid 43877431)
9. Cohen SP, Johns Hopkins University: Efficacy of epidural etanercept in the treatment of sciatica. ClinicalTrials.gov identifier: NCT00364572. Completed December 2007 (http: //www. clinicaltrials.gov/show/NCT00364572) [Accessed 12 May 2008]
10. Daniell H, Guda C, McPherson DT, Zhang X, Xu J, Urry DW: Hyperexpression of a synthetic protein-based polymer gene. Methods Mol Biol 63:359-371, 1997
11. Dreher MR, Raucher D, Balu N, Michael Colvin O, Ludeman SM, Chilkoti A: Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. J Control Release 91:31-43, 2003 (Pubitemid 37303992)
12. Dri P, Gasparini C, Menegazzi R, Cramer R, Alberi L, Presani G, et al: TNF-Induced shedding of TNF receptors in human polymorphonuclear leukocytes: role of the 55-kDa TNF receptor and involvement of a membrane-bound and non-matrix metalloproteinase. J Immunol 165:2165-2172, 2000 (Pubitemid 30643166)
13. Engelmann H, Novick D, Wallach D: Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. J Biol Chem 265:1531-1536, 1990
14. Fehrenbacher JC, Burkey TH, Nicol GD, Vasko MR: Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells. Pain 113: 113-122, 2005
15. Fine SM, Angel RA, Perry SW, Epstein LG, Rothstein JD, Dewhurst S, et al: Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. J Biol Chem 271:15303-15306, 1996
16. Genevay S, Stingelin S, Gabay C: Efficacy of etanercept in the treatment of acute, severe sciatica: a pilot study. Ann Rheum Dis 63:1120-1123, 2004 (Pubitemid 39120364)
17. George A, Kleinschnitz C, Zelenka M, Brinkhoff J, Stoll G, Sommer C: Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein. Exp Neurol 188:187-191, 2004 (Pubitemid 38748817)
18. Gerain J, Lienard D, Pampallona S, Baumgartner M, Ruegg C, Buurman WA, et al: Systemic release of soluble TNF receptors after high-dose TNF in isolated limb perfusion. Cytokine 9: 1034-1042, 1997 (Pubitemid 28026671)
19. Hale KK, Smith CG, Baker SL, Vanderslice RW, Squires CH, Gleason TM, et al: Multifunctional regulation of the biological effects of TNF-alpha by the soluble type I and type II TNF receptors. Cytokine 7:26-38, 1995
20. Heidenreich S, Weyers M, Gong JH, Sprenger H, Nain M, Gemsa D: Potentiation of lymphokine-induced macrophage activation by tumor necrosis factor-alpha. J Immunol 140:1511-1518, 1988 (Pubitemid 18103576)
21. Igarashi T, Kikuchi S, Shubayev V, Myers RR: 2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 25:2975-2980, 2000
22. Igwe OJ, Murray JN, Moolwaney AS: Interleukin 1-induced cyclooxygenase and nitric oxide synthase gene expression in the rat dorsal root ganglia is modulated by antioxidants. Neuroscience 105:971-985, 2001
23. Joyce DA, Gibbons DP, Green P, Steer JH, Feldmann M, Brennan FM: Two inhibitors of pro-inflammatory cytokine release, interleukin- 10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur J Immunol 24:2699-2705, 1994 (Pubitemid 24342185)
24. Korhonen T, Karppinen J, Malmivaara A, Autio R, Niinimaki J, Paimela L, et al: Efficacy of infliximab for disc herniation-induced sciatica: one-year follow-up. Spine 29:2115-2119, 2004 (Pubitemid 40353199)
25. Lantz M, Bjornberg F, Olsson I, Richter J: Adherence of neutrophils induces release of soluble tumor necrosis factor receptor forms. J Immunol 152:1362-1369, 1994 (Pubitemid 24134365)
26. Liu S, Tobias R, McClure S, Styba G, Shi Q, Jackowski G: Removal of endotoxin from recombinant protein preparations. Clin Biochem 30:455-463, 1997 (Pubitemid 27418541)
27. McHale MK, Setton LA, Chilkoti A: Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. Tissue Eng 11:1768-1779, 2005
28. McPherson DT, Xu J, Urry DW: Product purification by reversible phase transition following Escherichia coli expression of genes encoding up to 251 repeats of the elastomeric pentapeptide GVGVP. Protein Expr Purif 7:51-57, 1996 (Pubitemid 26263285)
29. Mecham RP, Hinek A, Griffin GL, Senior RM, Liotta LA: The elastin receptor shows structural and functional similarities to the 67-kDa tumor cell laminin receptor. J Biol Chem 264:16652-16657, 1989
30. Munson TE: Guideline for validation of the LAL test as an end-product endotoxin test for human and biological drug products. Prog Clin Biol Res 189:211-220, 1985
31. Nicol GD, Cui M: Enhancement by prostaglandin E2 of bradykinin activation of embryonic rat sensory neurones. J Physiol 480:485-492, 1994
32. Olmarker K, Nordborg C, Larsson K, Rydevik B: Ultrastructural changes in spinal nerve roots induced by autologous nucleus pulposus. Spine 21:411-414, 1996 (Pubitemid 26067847)
33. Olmarker K, Rydevik B: Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica. Spine 26:863-869, 2001 (Pubitemid 32373971)
34. Olmarker K, Storkson R, Berge OG: Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc herniation. Spine 27:1312-1317, 2002 (Pubitemid 34655138)
35. Onda A, Yabuki S, Kikuchi S: Effects of neutralizing antibodies to tumor necrosis factor-alpha on nucleus pulposus-induced abnormal nociresponses in rat dorsal horn neurons. Spine 28:967-972, 2003 (Pubitemid 36583324)
36. Peppel K, Crawford D, Beutler B: A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity. J Exp Med 174:1483-1489, 1991
37. Rodriguez-Cabello JC, Reguera J, Girotti A, Alonso M, Testera AM: Developing functionality in elastin-like polymers by increasing their molecular complexity: the power of the genetic engineering approach. Prog Polym Sci 30:1119-1145, 2005
38. Sawada T, Sano M, Omura T, Omura K, Hasegawa T, Funahashi S, et al: Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 after crush injury in rat sciatic nerve utilizing immunohistochemistry. Neurosci Lett 417:55-60, 2007 (Pubitemid 46517837)
39. Scheinfeld N: A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Dermatolog Treat 15:280-294, 2004
40. Segond von Banchet G, Scholze A, Schaible HG: Prostaglandin E2 increases the expression of the neurokinin1 receptor in adult sensory neurones in culture: a novel role of prostaglandins. Br J Pharmacol 139:672-680, 2003 (Pubitemid 36819637)
41. Shamji MF, Betre H, Kraus VB, Chen J, Chilkoti A, Pichika R, et al: Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis Rheum 56:3650-3661, 2007 (Pubitemid 350100699)
42. Shamji MF, Chen J, Friedman AH, Richardson WJ, Chilkoti A, Setton LA: Synthesis and characterization of a thermally responsive tumor necrosis factor antagonist. J Control Release [in press], 2008
43. Shamji MF, Whitlatch L, Friedman AH, Richardson WJ, Chilkoti A, Setton LA: An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration. Spine 33:748-754, 2008
44. Solorzano CC, Kaibara A, Hess PJ, Edwards PD, Ksontini R, Abouhamze A, et al: Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon. J Appl Physiol 84:1119-1130, 1998 (Pubitemid 28158673)
45. Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, Kuno R, et al: Tumor necrosis factor-{alpha}induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 281:21362-21368, 2006 (Pubitemid 44115475)
46. Urry DW: Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers. J Phys Chem B 101:11007-11028, 1997
47. Urry DW, Parker TM, Reid MC, Gowda DC: Biocompatibility of the bioelastic materials, Poly(GVGVP) and its gamma-irradiation cross-linked matrix: summary of generic biological test results. J Bioact Compat Polym (USA) 6:263-282, 1991
48. Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN: Interleukin- 6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci 19:5236-5244, 1999 (Pubitemid 29300191)
49. Weiler C, Nerlich AG, Bachmeier BE, Boos N: Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 30:44-54, 2005 (Pubitemid 40209276)
50. Winkelstein BA, Weinstein JN, DeLeo JA: The role of mechanical deformation in lumbar radiculopathy: an in vivo model. Spine 27:27-33, 2002
51. Xie WR, Deng H, Li H, Bowen TL, Strong JA, Zhang JM: Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia. Neuroscience 142:809-822, 2006 (Pubitemid 44485910)
52. Xu XJ, Hao JX, Andell-Jonsson S, Poli V, Bartfai T, Wiesenfeld- Hallin Z: Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section. Cytokine 9:1028-1033, 1997 (Pubitemid 28026670)
53. Zhu J, Bai XF, Mix E, Link H: Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL- 10, IL-12, TNF-alpha, TNF-beta, and cytolysin. Clin Immunol Immunopathol 84:85-94, 1997 (Pubitemid 27293547)