Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-γ generation

Immunology

Volumn 104, Issue 2, 2001, Pages 157-161

  Leal, Irene S ^a   Smedegård, Birgitte ^b   Andersen, Peter ^b   Appelberg, Rui ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b Statens Seruminstitut ^*  (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; GAMMA INTERFERON; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; LYMPHOCYTE PROLIFERATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TUBERCULOSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, MONOCLONAL; BCG VACCINE; CELL CULTURE TECHNIQUES; FEMALE; INTERFERON TYPE II; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; TH1 CELLS; TUBERCULOSIS;

EID: 0034771680     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01305.x     Document Type: Article

References (28)

1. Disseminated tuberculosis in interferon γ gene-disrupted mice
2. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection
3. IL-12 and IFN-γ in host defense against myco-bacteria and salmonella in mice and men
4. Tuberculosis subunit vaccine development: On the role of interferon-γ
5. Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine
6. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis
7. Evaluation of IL-12 in immuno-therapy and vaccine design in experimental Mycobacterium avium infections
8. Proteins released from Mycobacterium tuberculosis during growth
9. Mouse model of tuberculosis
10. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis
11. IL6 regulates the phenotype of the immune response to a tuberculosis sub-unit vaccine
12. Interleukin-6 induces early gamma interferon production in the infected lung but is not required for generation of specific immunity to Mycobacterium tuberculosis infection
13. Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
14. Interferon γ eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells
15. Gamma interferon induces Fas-dependent apoptosis of Peyer's patch T cells in mice following peroral infection with Toxoplasma gondii
16. Interferon γ plays a critical role in induced cell death of effector T cell: A possible third mechanism of self-tolerance
17. Gamma inter-feron modulates CD95 (Fas) and CD95 ligand (Fas-L) expression and nitric oxide induced apoptosis during the acute phase of Trypanosoma cruzi infection: A possible role in immune response control
18. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences
19. The immuno-genicity of single and combination DNA vaccines against tuberculosis
20. The 19-KD antigen and protective immunity in a murine model of tuberculosis
21. Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae
22. Defining the requirements for immunological control of mycobacterial infections
23. Immune responses in tuberculosis
24. Differences in resistance of C57Bl/6 and C57Bl/10 mice to infection by Mycobacterium avium are independent of gamma interferon
25. Resistance of virulent Mycobacterium avium to gamma interferon-mediated antimicrobial activity suggests additional signals for induction of mycobacteriostasis
26. Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin
27. + T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon γ and nitric oxide synthase 2
28. Correlates of protective immunity to Mycobacterium tuberculosis in humans