Rapamycin reduces high-amplitude, mechanical stretch-induced apoptosis in pulmonary microvascular endothelial cells

Microvascular Research

Volumn 77, Issue 3, 2009, Pages 297-303

  Raaz, Uwe ^a   Kuhn, Hartmut ^a   Wirtz, Hubert ^a   Hammerschmidt, Stefan ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Cell death; Cytoskeleton; Mechanical stretch

Indexed keywords

ACTIN; F ACTIN; PROTEIN KINASE B; RAPAMYCIN;

APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG BLOOD VESSEL; LUNG INJURY; MECHANICAL STIMULATION; PRIORITY JOURNAL; PROTEIN CONTENT;

ANTI-BACTERIAL AGENTS; APOPTOSIS; BIOMECHANICS; CELL SURVIVAL; ENDOTHELIUM, VASCULAR; HUMANS; MECHANOTRANSDUCTION, CELLULAR; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ALVEOLI; SIROLIMUS; STRESS, MECHANICAL;

EID: 64049092255     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2009.01.012     Document Type: Article

References (28)

1. 1999. International consensus conferences in intensive care medicine. Ventilator-associated lung injury in ARDS. American Thoracic Society, European Society of Intensive Care Medicine, Societe de Reanimation Langue Francaise. Intensive Care Med 25, 1444-1452.
2. Asnaghi L., Calastretti A., Bevilacqua A., D'Agnano I., Gatti G., Canti G., Delia D., Capaccioli S., and Nicolin A. Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene 23 (2004) 5781-5791
3. Dimmeler S., Assmus B., Hermann C., Haendeler J., and Zeiher A.M. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ. Res. 83 (1998) 334-341
4. Edwards Y.S., Sutherland L.M., Power J.H., Nicholas T.E., and Murray A.W. Cyclic stretch induces both apoptosis and secretion in rat alveolar type II cells. FEBS Lett. 448 (1999) 127-130
5. Edwards Y.S., Sutherland L.M., and Murray A.W. NO protects alveolar type II cells from stretch-induced apoptosis. A novel role for macrophages in the lung. Am. J. Physiol., Lung Cell. Mol. Physiol. 279 (2000) 1236-1242
6. Gomez-Cambronero J. Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Lett. 550 (2003) 94-100
7. Hammerschmidt S., Kuhn H., Grasenack T., Gessner C., and Wirtz H. Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type II cells. Am. J. Respir. Cell Mol. Biol. 30 (2004) 396-402
8. Hammerschmidt S., Kuhn H., Sack U., Schlenska A., Gessner C., Gillissen A., and Wirtz H. Mechanical stretch alters alveolar type II cell mediator release toward a proinflammatory pattern. Am. J. Respir. Cell Mol. Biol. 33 (2005) 203-210
9. Hammerschmidt S., Kuhn H., Gessner C., Seyfarth H.J., and Wirtz H. Stretch-induced alveolar type II cell apoptosis - role of endogenous bradykinin and PI3K-Akt signaling. Am. J. Respir. Cell. Mol. Biol. 37 6 (2007) 699-705
10. Hosoi H., Dilling M.B., Shikata T., Liu L.N., Shu L., Ashmun R.A., Germain G.S., Abraham R.T., and Houghton P.J. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 59 (1999) 886-894
11. Ingber D.E. Cellular mechanotransduction: putting all the pieces together again. FASEB J. 20 (2006) 811-827
12. Kajstura J., and Reiss K. F-actin organization influences the osmotic reactions of animal cells. Folia Histochem. Cytobiol. 27 (1989) 201-208
13. Kasas S., Wang X., Hirling H., Marsault R., Huni B., Yersin A., Regazzi R., Grenningloh G., Riederer B., Forro L., Dietler G., and Catsicas S. Superficial and deep changes of cellular mechanical properties following cytoskeleton disassembly. Cell Motil. Cytoskelet. 62 (2005) 124-132
14. Ko K.S., and McCulloch C.A. Partners in protection: interdependence of cytoskeleton and plasma membrane in adaptations to applied forces. J. Membr. Biol. 174 (2000) 85-95
15. Liu M., Tanswell A.K., and Post M. Mechanical force-induced signal transduction in lung cells. Am. J. Physiol. 277 (1999) L667-L683
16. Liu X.M., Ensenat D., Wang H., Schafer A.I., and Durante W. Physiologic cyclic stretch inhibits apoptosis in vascular endothelium. FEBS Lett. 541 (2003) 52-56
17. Menke A., and Jockusch H. Extent of shock-induced membrane leakage in human and mouse myotubes depends on dystrophin. J. Cell. Sci. 108 Pt 2 (1995) 727-733
18. Muthukkumar S., Ramesh T.M., and Bondada S. Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. Transplantation 60 (1995) 264-270
19. Qian Y., Corum L., Meng Q., Blenis J., Zheng J.Z., Shi X., Flynn D.C., and Jiang B.H. PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am. J. Physiol., Cell Physiol. 286 (2004) 153-163
20. Qian Y., Zhong X., Flynn D.C., Zheng J.Z., Qiao M., Wu C., Dedhar S., Shi X., and Jiang B.H. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene 24 (2005) 3154-3165
21. Shi Y., Frankel A., Radvanyi L.G., Penn L.Z., Miller R.G., and Mills G.B. Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res. 55 (1995) 1982-1988
22. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med. 342 (2000) 1301-1308
23. Tschumperlin D.J., and Margulies S.S. Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro. Am. J. Physiol. 275 (1998) 1173-1183
24. Tschumperlin D.J., and Margulies S.S. Alveolar epithelial surface area-volume relationship in isolated rat lungs. J. Appl. Physiol. 86 (1999) 2026-2033
25. Tschumperlin D.J., Oswari J., and Margulies A.S. Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude. Am. J. Respir. Crit. Care Med. 162 (2000) 357-362
26. Wakatsuki T., Schwab B., Thompson N.C., and Elson E.L. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J. Cell. Sci. 114 (2001) 1025-1036
27. Wang N. Mechanical interactions among cytoskeletal filaments. Hypertension 32 (1998) 162-165
28. West J.B. Thoughts on the pulmonary blood-gas barrier. Am. J. Physiol., Lung Cell. Mol. Physiol. 285 (2003) L501-L513