The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes

PLoS ONE

Volumn 4, Issue 3, 2009, Pages

  Hennah, William ^a,b   Porteous, David ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 3 (2 PYRROLIDINYLMETHOXY)PYRIDINE; AL 108; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FARAMPATOR; MEMANTINE; MIRTAZAPINE; NEUROLEPTIC AGENT; NEUROPEPTIDE; PROTEIN NDE1; PROTEIN PDE4D; RILUZOLE; TOPIRAMATE; UNCLASSIFIED DRUG; DISC1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; NDE1 PROTEIN, HUMAN; NERVE PROTEIN; PDE4B PROTEIN, HUMAN; PDE4D PROTEIN, HUMAN; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV;

ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; BIPOLAR DISORDER; CYTOSKELETON; DEPRESSION; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NEUROPATHOLOGY; PSYCHOSIS; SCHIZOPHRENIA; SENSATION; SYNAPTOGENESIS; FACTUAL DATABASE; GENE REGULATORY NETWORK; GENETIC PREDISPOSITION; GENETICS; MENTAL DISEASE; METABOLISM; PERCEPTION; PHYSIOLOGY; SYNAPSE;

CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DATABASES, FACTUAL; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MENTAL DISORDERS; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; PERCEPTION; SYNAPSES;

EID: 64049088120     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004906     Document Type: Article

References (33)

1. Harrison PJ, Weinberger DR (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10: 40-68.
2. Shi J, Gershon ES, Liu C (2008) Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes. Schizophr Res 104: 96-107.
3. Bray NJ (2008) Gene expression in the etiology of schizophrenia. Schizophr Bull 34: 412-418.
4. Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, et al. (2007) Population genomics of human gene expression. Nat Genet 39: 1217-1224.
5. Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK (2008) The DISC locus in psychiatric illness. Mol Psychiatry 13: 36-64.
6. Clapcote SJ, Lipina TV, Millar JK, Mackie S, Christie S, et al. (2007) Behavioral phenotypes of Disc1 missense mutations in mice. Neuron 54: 387-402.
7. Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, et al. (2007) Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A 104: 14501-14506.
8. Kamiya A, Kubo K, Tomoda T, Takaki M, Youn R, et al. (2005) A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol 7: 1167-1178.
9. Li W, Zhou Y, Jentsch JD, Brown RA, Tian X, et al. (2007) Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A 104: 18280-18285.
10. Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, et al. (2008) DISC1 Association, Heterogeneity and Interplay in Schizophrenia and Bipolar Disorder. Molecular Psychiatry (epub ahead of print).
11. Hennah W, Tomppo L, Hiekkalinna T, Palo OM, Kilpinen H, et al. (2007) Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum Mol Genet 16: 453-462.
12. Pickard BS, Thomson PA, Christoforou A, Evans KL, Morris SW, et al. (2007) The PDE4B gene confers sex-specific protection against schizophrenia. Psychiatr Genet 17: 129-133.
13. Sullivan PF, Fan C, Perou CM (2006) Evaluating the comparability of gene expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet 141B: 261-268.
14. Millar JK, Pickard BS, Mackie S, James R, Christie S, et al. (2005) DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310: 1187-1191.
15. Lipska BK, Peters T, Hyde TM, Halim N, Horowitz C, et al. (2006) Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum Mol Genet 15: 1245-1258.
16. Stranger BE, Forrest MS, Dunning M, Ingle CE, Beazley C, et al. (2007) Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315: 848-853.
17. Cheung VG, Spielman RS, Ewens KG, Weber TM, Morley M, et al. (2005) Mapping determinants of human gene expression by regional and genome-wide association. Nature 437: 1365-1369.
18. Monks SA, Leonardson A, Zhu H, Cundiff P, Pietrusiak P, et al. (2004) Genetic inheritance of gene expression in human cell lines. Am J Hum Genet 75: 1094-1105.
19. Carter CJ (2006) Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability. Schizophr Res 86: 1-14.
20. Hakak Y, Walker JR, Li C, Wong WH, Davis KL, et al. (2001) Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 98: 4746-4751.
21. Carter CJ (2007) eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia? Schizophr Bull 33: 1343-1353.
22. Vawter MP, Thatcher L, Usen N, Hyde TM, Kleinman JE, et al. (2002) Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia. Mol Psychiatry 7: 571-578.
23. Takao T, Tachikawa H, Kawanishi Y, Mizukami K, Asada T (2007) CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: a preliminary study. Eur Neuropsychopharmacol 17: 273-276.
24. Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, et al. (2008) Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320: 539-543.
25. International Schizophrenia Consortium (2008) Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455: 237-241.
26. Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, et al. (2008) Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet 40: 880-885.
27. Zhang B, Schmoyer D, Kirov S, Snoddy J (2004) GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics 5: 16.
28. Porteous DJ, Millar JK (2006) Disrupted in schizophrenia 1: building brains and memories. Trends Mol Med 12: 255-261.
29. Bradshaw NJ, Ogawa F, Antolin-Fontes B, Chubb JE, Carlyle BC, et al. (2008) DISC1, PDE4B, and NDE1 at the Centrosome and Synapse. Biochem Biophys Res Commun.
30. Kapur S (2003) Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 160: 13-23.
31. The HapMap Consortium (2005) A haplotype map of the human genome. Nature 437: 1299-1320.
32. Dai M, Wang P, Boyd AD, Kostov G, Athey B, et al. (2005) Evolving gene/ transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res 33: e175.
33. Hedrick PW (1987) Gametic disequilibrium measures: proceed with caution. Genetics 117: 331-341.