Nuclear progesterone receptor expression in the human fetal membranes and decidua at term before and after labor

Reproductive Sciences

Volumn 16, Issue 4, 2009, Pages 357-363

  Merlino, Amy ^a   Welsh, Toni ^c   Erdonmez, Tan ^d   Madsen, Gemma ^d   Zakar, Tamas ^d   Smith, Roger ^d   Mercer, Brian ^a   Mesiano, Sam ^b,c  

^a METROHEALTH MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Fetal membranes; Human parturition.; Progesterone receptors

Indexed keywords

PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B;

AMNION; ARTICLE; CELLULAR DISTRIBUTION; CESAREAN SECTION; CHORION; CONTROLLED STUDY; DECIDUA; FETUS MEMBRANE; HUMAN; HUMAN TISSUE; LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TERM BIRTH;

AMNION; BLOTTING, WESTERN; CELL NUCLEUS; CHORION; DECIDUA; EXTRAEMBRYONIC MEMBRANES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LABOR, OBSTETRIC; PARTURITION; PREGNANCY; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 63849329028     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719108328616     Document Type: Article

References (22)

1. Frydman R., Fernandez H., Pons JC, Ulmann A. Mifepristone (RU486) and therapeutic late pregnancy termination: a double-blind study of two different doses. Hum Reprod. 1988 ; 3: 803-806.
2. Mahajan DK, London SN Mifepristone (RU486): a review. Fertil Steril. 1997 ; 68: 967-976.
3. Neilson JP Mifepristone for induction of labour. Cochrane Database Syst Rev. 2000 :CD002865.
4. Merlino AA, Welsh TN, Tan H., et al. Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A. J Clin Endocrinol Metab. 2007 ; 92: 1927-1933.
5. Goldman S., Weiss A., Almalah I., Shalev E. Progesterone receptor expression in human decidua and fetal membranes before and after contractions: possible mechanism for functional progesterone withdrawal. Mol Hum Reprod. 2005 ; 11: 269-277.
6. Khan-Dawood FS, Dawood MY Estrogen and progesterone receptor and hormone levels in human myometrium and placenta in term pregnancy. Am J Obstet Gynecol. 1984 ; 150: 501-505.
7. Mills AA, Yonish B., Feng L., Schomberg DW, Heine RP, Murtha AP Characterization of progesterone receptor isoform expression in fetal membranes. Am J Obstet Gynecol. 2006 ; 195: 998-1003.
8. Oh SY, Kim CJ, Park I., et al. Progesterone receptor isoform (A/B) ratio of human fetal membranes increases during term parturition. Am J Obstet Gynecol. 2005 ; 193: 1156-1160.
9. Taylor AH, McParland PC, Taylor DJ, Bell SC The progesterone receptor in human term amniochorion and placenta is isoform C. Endocrinology. 2006 ; 147: 687-693.
10. Wu WX, Brooks J., Millar MR, Ledger WL, Glasier AF, McNeilly AS Immunolocalization of oestrogen and progesterone receptors in the human decidua in relation to prolactin production. Hum Reprod. 1993 ; 8: 1129-1135.
11. Young IR The comparative physiology of parturition in mammals. Front Horm Res. 2001 ; 27: 10-30.
12. Tulchinsky D., Hobel CJ, Yeager E., Marshall JR Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol. 1972 ; 112: 1095-1100.
13. Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol. 2000 ; 20: 3102-3115.
14. Tung L., Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol. 1993 ; 7: 1256-1265.
15. Vegeto E., Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol. 1993 ; 7: 1244-1255.
16. Mesiano S., Chan EC, Fitter JT, Kwek K., Yeo G., Smith R. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab. 2002 ; 87: 2924-2930.
17. Chomczynski P., Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987 ; 162: 156-159.
18. Madsen G., MacIntyre DA, Mesiano S., Smith R. Progesterone receptor or cytoskeletal protein ? Reprod Sci. 2007 ; 14: 217-222.
19. Samalecos A., Gellersen B. Systematic expression analysis and antibody screening do not support the existence of naturally occurring PR-C, PR-M or other truncated progesterone receptor isoforms. Endocrinology. 2008 ; 149: 5872-5887.
20. Mahendroo MS, Porter A., Russell DW, Word RA The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol. 1999 ; 13: 981-992.
21. Andersson S., Minjarez D., Yost NP, Word RA Estrogen and progesterone metabolism in the cervix during pregnancy and parturition. J Clin Endocrinol Metab. 2008 ; 93: 2366-2374.
22. Condon JC, Jeyasuria P., Faust JM, Wilson JW, Mendelson CR A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc Natl Acad Sci U S A. 2003 ; 100: 9518-9523.