Organofluorosilanes as model compounds for18F-labeled silicon-based PET tracers and their hydrolytic stability: Experimental data and theoretical calculations (PET = Positron Emission Tomography)

Chemistry - A European Journal

Volumn 15, Issue 15, 2009, Pages 3736-3743

  Höhne, Aileen ^a   Yu, Lian ^a   Mu, Linjing ^a   Reiher, Markus ^a   Voigtmann, Ulrike ^b   Klar, Ulrich ^b   Graham, Keith ^b   Schubiger, P August ^a   Ametamey, Simon M ^a  

^a ETH ZURICH   (Switzerland)

^b BAYER PHARMA AG   (Germany)

Author keywords

Density functional calculations; Hydrolysis; Organofluorosilanes; Positron emission tomography; Synthesis design

Indexed keywords

BUILDING BLOCKS; DEFLUORINATION; DENSITY FUNCTIONAL CALCULATIONS; DENSITY FUNCTIONAL THEORY METHODS; EXPERIMENTAL DATUM; HALF-LIVES; HYDROLYTIC STABILITIES; INTERMEDIATE STRUCTURES; MODEL COMPOUNDS; OPTIMIZED STRUCTURES; ORGANOFLUOROSILANES; PET IMAGING; PET TRACERS; PHYSIOLOGICAL CONDITIONS; SILICON CHEMISTRIES; SILICON-BASED; STARTING MATERIALS; SYNTHESIS DESIGN; THEORETICAL CALCULATIONS; THEORETICAL MODELS;

BIOMOLECULES; COMPLEXATION; DENSITY FUNCTIONAL THEORY; DIAGNOSTIC RADIOGRAPHY; ELECTRONS; FLUORINE; HYDROLYSIS; POSITRON ANNIHILATION SPECTROSCOPY; POSITRONS; SILANES; STABILITY; STRUCTURAL DESIGN; SYNTHESIS (CHEMICAL);

POSITRON EMISSION TOMOGRAPHY;

FLUORINE; SILANE DERIVATIVE; SILICON; WATER;

ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; METHODOLOGY; POSITRON EMISSION TOMOGRAPHY; SYNTHESIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; HYDROLYSIS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; SILANES; SILICON; WATER;

EID: 63849316541     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200802437     Document Type: Article

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