Overlapping functions of cdxl cdx2, and cdx4 in the development of the amphibian xenopus tropicalis

Developmental Dynamics

Volumn 238, Issue 4, 2009, Pages 835-852

  Faas, Laura ^a   Isaacs, Harry V ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Caudal; Cdx; Endoderm; Hox; Mesoderm; Morphogenesis; Wnt; Xenopus

Indexed keywords

COMPLEMENTARY DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR CDX4; UNCLASSIFIED DRUG; WNT3A PROTEIN; ANTISENSE OLIGONUCLEOTIDE; HOMEODOMAIN PROTEIN; WNT PROTEIN;

AMPHIBIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; ENDODERM; FEMALE; GASTRULATION; GENE CONTROL; GENE EXPRESSION; HOX GENE; LARVAL STAGE; MORPHOGENESIS; NEURULATION; NONHUMAN; PHENOTYPE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA TRANSLATION; TISSUE DISTRIBUTION; XENOPUS TROPICALIS; ANIMAL; ANIMAL EMBRYO; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; MESODERM; METABOLISM; MULTIGENE FAMILY; PRENATAL DEVELOPMENT; PROTEIN SYNTHESIS; XENOPUS; XENOPUS LAEVIS;

AMPHIBIA; VERTEBRATA; XENOPUS TROPICALIS;

ANIMALS; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; LARVA; MESODERM; MULTIGENE FAMILY; OLIGONUCLEOTIDES, ANTISENSE; PHENOTYPE; PROTEIN BIOSYNTHESIS; WNT PROTEINS; XENOPUS; XENOPUS LAEVIS;

EID: 63849233073     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21901     Document Type: Article

References (63)

1. Beck CW, Slack JM. 1999. A developmental pathway controlling outgrowth of the Xenopus tail bud. Development 126:1611-1620.
2. Beck F, Chawengsaksophak K, Waring P, Playford RJ, Furness JB. 1999. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci USA 96:7318-7323.
3. Beck F. 2004. The role of Cdx genes in the mammalian gut. Gut 53:1394-1396.
4. Bel-Vialar S, Itasaki N, Krumlauf R. 2002. initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development 129:5103-5115.
5. Brooke NM, Garcia-Ferniandez J, Holland PW. 1998. The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature 392:920 -922.
6. Chalmers AD, Slack JM. 2000. The Xenopus tadpole gut: fate maps and morphogenetic movements. Development 127:381-392.
7. Chalmers AD, Slack JM, Beck CW. 2000. Regional gene expression in the epithelia of the Xenopus tadpole gut. Mech Dev 96:125-128.
8. Charite J, de Graaff W, Consten D, Reijnen MJ, Korving J, Deschamps J. 1998. Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements. Development 125:4349 -4358.
9. Chawengsaksophak K, James R, Hammond VE, Kontgen F, Beck F. 1997. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386:84-87.
10. Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F. 2004. Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A 101:7641-7645.
11. Costa RM, Mason J, Lee M, Amaya E, Zorn AM. 2003. Novel gene expression domains reveal early patterning of the Xenopus endoderm. Gene Expr Patterns 3:509-519.
12. Davidson AJ, Zon LI. 2006. The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis. Dev Biol 292:506 -518.
13. Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. 2003. Cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature 425:300-306.
14. Epstein M, Pillemer G, Yelin R, Yisraeli JK, Fainsod A. 1997. Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes. Development 124:3805-3814.
15. Ferrier DEK, Dewar K, Cook A, Chang JL, Hill-Force A, Amemiya C. 2005. The chordate ParaHox gene cluster. Curr Biol 15:820-822.
16. Gamer LW, Wright CVE. 1993. Murine Cdx-4 bears striking similarity to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. Mech Dev 43:71-81.
17. Gaunt SJ, Drage D, Cockley A. 2003. Vertebrate caudal gene expression gradients investigated by use of chick cdx-A/lacZ and mouse cdx-1/lacZ reporters in transgenic mouse embryos: evidence for an intron enhancer. Mech Dev 120:573-586.
18. Gaunt SJ, Cockley A, Drage D. 2004. Additional enhancer copies, with intact cdx binding sites, anteriorize Hoxa-7/lacZ expression in mouse embryos: evidence in keeping with an instructional cdx gradient. int J Dev Biol 48:613-622.
19. Gaunt SJ, Drage D, Trubshaw RC. 2008. increased Cdx protein dose effects upon axial patterning in transgenic lines of mice. Development 135:2511-2520.
20. Godsave S, Dekker EJ, Holling T, Pannese M, Boncinelli E, Durston A. 1994. Expression patterns of Hoxb genes in the Xenopus embryo suggest roles in anteroposterior specification of the hindbrain and in dorsoventral patterning of the mesoderm. Dev Biol 166:465-476.
21. Guo RJ, Suh ER, Lynch JP. 2004. The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 3:593-601.
22. Harland RM. 1991. in situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol 36:685-695.
23. Horb ME, Slack JM. 2001. Endoderm specification and differentiation in Xenopus embryos. Dev Biol 236:330 -343.
24. Hudson C, Clements D, Friday RV, Stott D, Woodland HR. 1997. Xsox17alpha and beta mediate endoderm formation in Xenopus. Cell 91:397-405.
25. Ikeya M, Takada S. 2001. Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech Dev 103:27-33.
26. Illes JC, Winterbottom EF, Isaacs HV. 2009. Cloning and expression analysis of the anterior ParaHox genes Gsh1 and Gsh2 from Xenopus tropicalis. Dev Dyn 238:194-203.
27. Isaacs HV, Tannahill D, Slack JMW. 1992. Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification. Development 114:711-720.
28. Isaacs HV, Pownall ME, Slack JMW. 1998. Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3. EMBO J 17:3413-3427.
29. Katsuyama Y, Sato Y, Wada S, Saiga H. 1999. Ascidian tail formation requires caudal function. Dev Biol 213:257-268.
30. Keenan ID, Sharrard RM, Isaacs HV. 2006. FGF signal transduction and the regulation of Cdx gene expression. Dev Biol 299:478-488.
31. Khokha MK, Yeh J, Grammer TC, Harland RM. 2005. Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structures. Dev Cell 8:401-411.
32. Kilian B, Mansukoski H, Barbosa FC, Ul-rich F, Tada M, Heisenberg CP. 2003. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev 120:467-476.
33. Larkin K, Danilchik MV. 1999. Ventral cell rearrangements contribute to anterior-posterior axis lengthening between neurula and tailbud stages in Xenopus laevis. Dev Biol 216:550 -560.
34. Levy V, Marom K, Zins S, Koutsia N, Yelin R, Fainsod A. 2002. The competence of marginal zone cells to become Spemann's organizer is controlled by Xcad2. Dev Biol 248:40-51.
35. Lohnes D. 2003. The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse. Bioessays 25:971-980.
36. MacDonald PM, Struhl G. 1986. A molecular gradient in early Drosophila embryos. Nature 324:537-545.
37. Marom K, Shapira E, Fainsod A. 1997. The chicken caudal genes establish an anterior-posterior gradient by partially overlapping temporal and spatial patterns of expression. Mech Dev 64:41-52.
38. Mead PE, Kelley CM, Hahn PS, Piedad O, Zon LI. 1998. SCL specifies hematopoietic mesoderm in Xenopus embryos. Development 125:2611-2620.
39. Meyer BI, Gruss P. 1993. Mouse Cdx-1 expression during gastrulation. Development 117:191-203.
40. Mlodzik M, Gehring WJ. 1987. Expression of the caudal gene in the germline of Drosophila: formation of an RNA and protein gradient during early embryo-genesis. Cell 48:465-478.
41. Mlodzik M, Gibson G, Gehring WJ. 1987. Effects of ectopic expression of caudal during Drosophila development. Development 109:271-277.
42. Mulley JF, Chiu CH, Holland PW. 2006. Breakup of a homeobox cluster after genome duplication in teleosts. Proc Natl Acad Sci USA 103:10369 -10372.
43. Mutoh H, Hakamata Y, Sato K, Eda A, Yanaka I, Honda S, Osawa H, Kaneko Y, Sugano K. 2002. Conversion of gastric mucosa to intestinal metaplasia in Cdx2- expressing transgenic mice. Biochem Biophys Res Commun 294:470 -479.
44. Nieuwkoop PD, Faber J. 1967. Normal Table of Xenopus laevis (Daudin). Amsterdam: North-Holland.
45. Onichtchouk D, Glinka A, Niehrs C. 1998. Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm. Development 125:1447-1456.
46. Pera EM, Martinez SL, Flanagan JJ, Brechner M, Wessely O, De Robertis EM. 2003. Darmin is a novel secreted protein expressed during endoderm development in Xenopus. Gene Expr Patt 3:147-152.
47. Pillemer G, Epstein M, Blumberg B, Yisraeli JK, De Robertis EM, Steinbeisser H, Fainsod A. 1998. Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis. Mech Dev 71:193-196.
48. Pilon N, Oh K, Sylvestre JR, Bouchard N, Savory J, Lohnes D. 2006. Cdx4 is a direct target of the canonical Wnt pathway. Dev Biol 289:55-63.
49. Pownall ME, Tucker AS, Slack JMW, Isaacs HV. 1996. eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus. Development 122:3881-3892.
50. Prinos P, Joseph S, Oh K, Meyer BI, Gruss P, Lohnes D. 2001. Multiple pathways governing Cdx1 expression during murine development. Dev Biol 239:257-269.
51. Reece-Hoyes JS, Keenan ID, Isaacs HV. 2002. The cloning and expression of the Cdx family from the frog Xenopus tropicalis. Dev Dyn 223:134-140.
52. Reece-Hoyes JS, Keenan ID, Pownall ME, Isaacs HV. 2005. A consensus Oct1 binding site is required for the activity of the Xenopus Cdx4 promoter. Dev Biol 282:509-23.
53. Ruiz i Altaba A, Melton DA. 1989. Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development. Development 106:173-183.
54. Shimizu T, Bae YK, Muraoka O, Hibi M. 2005. interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev Biol 279:125-141.
55. Showell C, Binder O, Conlon FL. 2004. T-box genes in early embryogenesis. Dev Dyn 229:201-218.
56. Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, Sackett SD, Kaestner KH. 2002. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 122:689-696.
57. Subramanian V, Meyer BI, Gruss P. 1995. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell 83:641-653.
58. Takada S, Stark KL, Shea MJ, Vassileva G, McMahon JA, McMahon AP. 1994. Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev 8:174-189.
59. van den Akker E, Forlani S, Chawengsaksophak K, de Graaff W, Beck F, Meyer BI, Deschamps J. 2002. Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development 129:2181-2193.
60. van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F, Deschamps J. 2006. The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development 133:419-428.
61. Wallingford JB. 2004. Closing in on vertebrate planar polarity. Nat Cell Biol 6:687-689.
62. Wallingford JB, Vogeli KM, Harland RM. 2001. Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway. Int J Dev Biol 45:225-227.
63. Yamaguchi TP, Bradley A, McMahon AP, Jones S. 1999. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126:1211-1223.