Attenuation of cerebral vasospasm and secondary injury by 17β-estradiol following experimental subarachnoid hemorrhage: Laboratory investigation

Journal of Neurosurgery

Volumn 110, Issue 3, 2009, Pages 457-461

  Lin, Chih Lung ^a   Dumont, Aaron S ^e   Su, Yu Feng ^a   Tsai, Yee Jean ^a   Huang, Jih Hui ^a   Chang, Kao Ping ^a,b   Howng, Shen Long ^a   Kwan, Aij Lie ^a   Kassell, Neal F ^e   Kao, Cheng Hsing ^c,d  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Adenosine A1 receptor; Cerebral vasospasm; Estrogen; Subarachnoid hemorrhage

Indexed keywords

ADENOSINE A1 RECEPTOR; DNA; ESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; BASILAR ARTERY; BRAIN CORTEX; BRAIN INJURY; BRAIN VASOSPASM; CELL DEATH; CONTROLLED STUDY; DENTATE GYRUS; DNA FRAGMENTATION; DRUG EFFICACY; HIPPOCAMPUS; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBARACHNOID HEMORRHAGE; ANIMAL; BRAIN ISCHEMIA; DRUG EFFECT; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN ISCHEMIA; DENTATE GYRUS; ESTRADIOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; SUBARACHNOID HEMORRHAGE; VASOSPASM, INTRACRANIAL;

EID: 63849210617     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2008.6.17622     Document Type: Article

References (24)

1. Cahill J, Calvert JW, Zhang JH: Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 26:1341-1353, 2006
2. Chiappetta O, Gliozzi M, Siviglia E, Amantea D, Morrone LA, Berliocchi L, et al: Evidence to implicate early modulation of interleukin-1beta expression in the neuroprotection afforded by 17beta-estradiol in male rats undergone transient middle cerebral artery occlusion. Int Rev Neurobiol 82:357-372, 2007
3. Cook DA: Mechanisms of cerebral vasospasm in subarachnoid haemorrhage. Pharmacol Ther 66:259-284, 1995
4. Darkow DJ, Lu L, White RE: Estrogen relaxation of coronary artery smooth muscle is mediated by nitric oxide and cGMP. Am J Physiol 272:H2765-H2773, 1997 (Pubitemid 27300453)
5. Davis P: Stroke in women. Curr Opin Neurol 7:36-40, 1994
6. Dubey RK, Jackson EK: Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms. Am J Physiol Renal Physiol 280:F365-F388, 2001
7. Endo H, Nito C, Kamada H, Yu F, Chan PH: Reduction in oxidative stress by superoxide dismutase overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/glycogen synthase kinase-3beta survival signaling. J Cereb Blood Flow Metab 27:975-982, 2007 (Pubitemid 46659025)
8. Kongable GL, Lanzino G, Germanson TP, Truskowski LL, Alves WM, Torner JC, et al: Gender-related differences in aneurysmal subarachnoid hemorrhage. J Neurosurg 84:43-48, 1996 (Pubitemid 26006995)
9. Lai DM, Tu YK, Liu IM, Cheng JT: Increase of adenosine A1 receptor gene expression in cerebral ischemia of Wistar rats. Neurosci Lett 387:59-61, 2005
10. Lin CL, Dumont AS, Wu SC, Wang CJ, Howng SL, Huang YF, et al: 17beta-estradiol inhibits endothelin-1 production and attenuates cerebral vasospasm after experimental subarachnoid hemorrhage. Exp Biol Med (Maywood) 231:1054-1057, 2006
11. Lin CL, Shih HC, Dumont AS, Kassell NF, Lieu AS, Su YF, et al: The effect of 17beta-estradiol in attenuating experimental subarachnoid hemorrhage-induced cerebral vasospasm. J Neurosurg 104:298-304, 2006
12. Lin CL, Su YF, Dumont AS, Shih HC, Lieu AS, Howng SL, et al: The effect of an adenosine A1 receptor agonist in the treatment of experimental subarachnoid hemorrhage-induced cerebrovasospasm. Acta Neurochir (Wien) 148:873-879, 2006
13. Liu R, Wang X, Liu Q, Yang SH, Simpkins JW: Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia. Neurosci Lett 415:237-241, 2007 (Pubitemid 46400270)
14. Logan M, Sweeney MI: Adenosine A1 receptor activation preferentially protects cultured cerebellar neurons versus astrocytes against hypoxia-induced death. Mol Chem Neuropathol 31:119-133, 1997 (Pubitemid 27391581)
15. Matz P, Weinstein P, States B, Honkaniemi J, Sharp FR: Subarachnoid injections of lysed blood induce the hsp70 stress gene and produce DNA fragmentation in focal areas of the rat brain. Stroke 27:504-513, 1996 (Pubitemid 26081450)
16. Nau R, Haase S, Bunkowski S, Bruck W: Neuronal apoptosis in the dentate gyrus in humans with subarachnoid hemorrhage and cerebral hypoxia. Brain Pathol 12:329-336, 2002 (Pubitemid 34743215)
17. Park S, Yamaguchi M, Zhou C, Calvert JW, Tang J, Zhang JH: Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke 35:2412-2417, 2004 (Pubitemid 39311273)
18. Prunell GF, Svendgaard NA, Alkass K, Mathiesen T: Delayed cell death related to acute cerebral blood flow changes following subarachnoid hemorrhage in the rat brain. J Neurosurg 102:1046-1054, 2005 (Pubitemid 43193974)
19. Shih HC, Lin CL, Lee TY, Lee WS, Hsu C: 17beta-estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transactivation. Stroke 37:3025-3031, 2006
20. Suzuki S, Brown CM, Dela Cruz CD, Yang E, Bridwell DA, Wise PM: Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions. Proc Natl Acad Sci U S A 104:6013-6018, 2007 (Pubitemid 47175650)
21. Von Lubitz DK, Lin RC, Bischofberger N, Beenhakker M, Boyd M, Lipartowska R, et al: Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist. Eur J Pharmacol 369:313-317, 1999 (Pubitemid 29155296)
22. Wang L, Shi JX, Yin HX, Ma CY, Zhang QR: The influence of subarachnoid hemorrhage on neurons: an animal model. Ann Clin Lab Sci 35:79-85, 2005 (Pubitemid 40396604)
23. Wen Y, Yang S, Liu R, Perez E, Yi KD, Koulen P, et al: Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia. Brain Res 1008:147-154, 2004 (Pubitemid 38624044)
24. Zhou C, Yamaguchi M, Colohan AR, Zhang JH: Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab 25:572-582, 2005 (Pubitemid 40562930)