17β-Estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor κB transactivation

Stroke

Volumn 37, Issue 12, 2006, Pages 3025-3031

  Shih, Huei Chuan ^a   Lin, Chih Lung ^a   Lee, Tzu Ying ^a   Lee, Wen Sen ^a,b   Hsu, Chin ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Estradiol; iNOS; Nuclear factor B; Stroke; Subarachnoid hemorrhage

Indexed keywords

CORN OIL; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; SILASTIC; SYNAPTOTAGMIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN VASOSPASM; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; DRUG IMPLANT; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; IMMUNOPRECIPITATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; STATISTICAL ANALYSIS; SUBARACHNOID HEMORRHAGE; TRANSACTIVATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ESTRADIOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; SUBARACHNOID HEMORRHAGE; TRANS-ACTIVATION (GENETICS);

EID: 33845416358     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000249008.18669.5a     Document Type: Article

References (24)

1. Schievink WI. Intracranial aneurysms. N Engl J Med. 1997;336:28-40.
2. Kaptain GJ, Lanzino G, Kassell NF. Subarachnoid haemorrhage: Epidemiology, risk factors, and treatment options. Drugs Aging. 2000;17:183-199.
3. Lin CL, Shih HC, Dumont AS, Kassell NF, Lieu AS, Su YF, Hwong SL, Hsu C. The effect of 17beta-estradiol in attenuating experimental subarachnoid hemorrhage-induced cerebral vasospasm. J Neurosurg. 2006;104:298-304.
4. Widenka DC, Medele RJ, Stummer W, Bise K, Steiger HJ. Inducible nitric oxide synthase: a possible key factor in the pathogenesis of chronic vasospasm after experimental subarachnoid hemorrhage. J Neurosurg. 1999;90:1098-1104.
5. Ahn KS, Aggarwal BB. Transcription factor NF-κB: a sensor for smoke and stress signals. Ann N Y Acad Sci. 2005;1056:218-233.
6. Ray P, Ghosh SK, Zhang DH, Ray A. Repression of interleukin-6 gene expression by 17 beta-estradiol: Inhibition of the DNA-binding activity of the transcription factors nf-il6 and nf-kappa b by the estrogen receptor. FEBS Lett. 1997;409:79-85.
7. Bakir B, Mori T, Durand J, Chen YF, Thompson JA, Oparil S. Estrogen-induced vasoprotection is estrogen receptor dependent: evidence from the balloon-injured rat carotid artery model. Circulation. 2000;101:2342-2344.
8. Suzuki H, Kanamaru K, Tsunoda H, Inada H, Kuroki M, Sun H, Waga S, Tanaka T. Heme oxygenase-1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats. J Clin Invest. 1999;104:59-66.
9. Davis P. Stroke in women. Curr Opin Neurol. 1994;7:36-40.
10. Provencio JJ, Vora N. Subarachnoid hemorrhage and inflammation: Bench to bedside and back. Semin Neurol. 2005;25:435-444.
11. Aihara Y, Kasuya H, Onda H, Hori T, Takeda J. Quantitative analysis of gene expressions related to inflammation in canine spastic artery after subarachnoid hemorrhage. Stroke. 2001;32:212-217.
12. Sayama T, Suzuki S, Fukui M. Expression of inducible nitric oxide synthase in rats following subarachnoid hemorrhage. Neurol Res. 1998;20:79-84.
13. Sayama T, Suzuki S, Fukui M. Role of inducible nitric oxide synthase in the cerebral vasospasm after subarachnoid hemorrhage in rats. Neurol Res. 1999;21:293-298.
14. Kuo PC, Abe K, Schroeder RA. Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. Gastroenterology. 2000;118:608-618.
15. Ono S, Date I, Onoda K, Shiota T, Ohmoto T, Ninomiya Y, Asari S, Morishita R. Decoy administration of NF-kappaB into the subarachnoid space for cerebral angiopathy. Hum Gene Ther. 1998;9:1003-1011.
16. Sun WH, Keller ET, Stebler BS, Ershler WB. Estrogen inhibits phorbol ester-induced I kappa B alpha transcription and protein degradation. Biochem Biophys Res Commun. 1998;244:691-695.
17. Ghisletti S, Meda C, Maggi A, Vegeto E. 17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization. Mol Cell Biol. 2005;25:2957-2968.
18. Spona J, Leibl H, Bieglmayer C. Nuclear translocation of estrogen-receptor complex and stimulation of rna synthesis by estrogens of different biological potencies in the female rat pituitary. Biochim Biophys Acta. 1980;607:189-200.
19. Geary GG, Krause DN, Duckles SP. Gonadal hormones affect diameter of male rat cerebral arteries through endothelium-dependent mechanisms. Am J Physiol Heart Circ Physiol. 2000;279:H160-H618.
20. Evans MJ, Eckert A, Lai K, Adelman SJ, Harnish DC. Reciprocal antagonism between estrogen receptor and nf-kappab activity in vivo. Circ Res. 2001;89:823-830.
21. Harnish DC, Scicchitano MS, Adelman SJ, Lyttle CR, Karathanasis SK. The role of cbp in estrogen receptor cross-talk with nuclear factor-kappaB in hepg2 cells. Endocrinology. 2000;141:3403-3411.
22. Deshpande R, Khalili H, Pergolizzi RG, Michael SD, Chang MD. Estradiol down-regulates lps-induced cytokine production and NFkB activation in murine macrophages. Am J Reprod Immunol. 1997;38:46-54.
23. Andersson C, Lydrup ML, Ferno M, Idvall I, Gustafsson J, Nilsson BO. Immunocytochemical demonstration of oestrogen receptor beta in blood vessels of the female rat, J Endocrinol. 2001;169:241-247.
24. Darblade B, Pendaries C, Krust A, Dupont S, Fouque MJ, Rami J, Chambon P, Bayard F, Arnal JF. Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor. Cir Res. 2002;90:413-441.