Personal reflections on observational and experimental research approaches to childhood psychopathology

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 50, Issue 1-2, 2009, Pages 36-43

  Rapoport, Judith L ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Attention deficit hyperactivity disorder; Child psychiatry; Childhood onset schizophrenia; Epidemiology; Experimental research; Follow up studies; Observational research; Obsessive compulsive disorder; Pervasive developmental disorder; Stimulants

Indexed keywords

CENTRAL STIMULANT AGENT; CLOMIPRAMINE; METHYLPHENIDATE; MOLINDONE;

ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; CHILD; CHILD PSYCHIATRY; CLINICAL RESEARCH; CLINICAL TRIAL; DISEASE ASSOCIATION; EXPERIMENTAL STUDY; FOLLOW UP; HUMAN; IMPULSE CONTROL DISORDER; MENTAL DISEASE; NEUROIMAGING; NEUROLOGIC DISEASE; OBSERVATIONAL STUDY; OBSESSIVE COMPULSIVE DISORDER; SCHIZOPHRENIA;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; HUMANS; MENTAL DISORDERS; OBSERVATION; PSYCHOLOGY, EXPERIMENTAL; PSYCHOPHARMACOLOGY; RESEARCH; SCHIZOPHRENIA, CHILDHOOD;

EID: 63849182542     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/j.1469-7610.2008.01975.x     Document Type: Article

References (64)

1. Addington, A.M., Gornick, M.C., Shaw, P., Seal, J., Gogtay, N., Greenstein, D., Clasen, L., Coffey, M., Gochman, P., Long, R., & Rapoport, J.L. (2007). Neuregulin 1 (8p12) and childhood-onset schizophrenia: Susceptibility haplotypes for diagnosis and brain developmental trajectories. Molecular Psychiatry, 12,195-205.
2. Albert, M.S. (2007). Changing the trajectory ofcognitive decline? The New England Journal of Medicine, 357, 502-503.
3. Bailey, A., Phillips, W., & Rutter, M. (1996). Autism: Towards an integration of clinical, genetic, neuro- psychological, and neurobiological perspectives. Journal of Child Psychology and Psychiatry, 37,89-126.
4. Bertilsson, L., Asberg, M., & Thoren, P. (1974). Differential effect of chlorimipramine and nortri- ptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression. European Journal of Clinical Pharmacology, 7, 365368.
5. Bradley, C. (1950). Benzedrine and dexedrine in the treatment of children's behavior disorders. Pediatrics,5, 24-36.
6. Caspi, A., McClay, J., Moffitt, T.E., Mill, J., Martin, J., Craig, I.W., Taylor, A., & Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851-854.
7. Caspi, A., & Moffitt, T.E. (2006). Gene-environment interactions in psychiatry: Joining forces with neuroscience. Nature Reviews, 7, 583-590.
8. Clarke, G.N., Hawkins, W., Murphy, M., Sheeber, L.B., Lewinsohn, P.M., & Seeley, J.R. (1995). Targeted prevention of unipolar depressive disorder in an at-risk sample of high school adolescents: A randomized trial of a group cognitive intervention. Journal of the American Academy ofChild and Adolescent Psychiatry, 34, 312-321.
9. Clegg, J., Hollis, C., Mawhood, L., & Rutter, M. (2005). Developmental language disorders - a follow-up in later adult life. Cognitive, language and psychosocial outcomes. Journal ofChild Psychology and Psychiatry, 46, 128-149.
10. Conners, C.K., & Eisenberg, L. (1963). The effects of methylphenidate on symptomatology and learning in disturbed children. American Journal ofPsychiatry, 120, 459-466.
11. Conners, C.K., Eisenberg, L., & Barcai, A. (1967). Effect of dextroamphetamine on children: Studies on subjects with learning disabilities and school behavior problems. Archives of General Psychiatry, 17, 478-485.
12. Durston, S., Fossella, J.A., Casey, B.J., Hulshoff Pol, H.E., Galvan, A., Schnack, H.G., Steenhuis, M.P., Minderaa, R.B., Buitelaar, J.K., Kahn, R.S., & Van Engeland, H. (2005). Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyper- activity disorder, their unaffected siblings, and controls. Molecular Psychiatry, 10, 678-685.
13. Eggers, C., Bunk, D., & Krause, D. (2000). Schizophrenia with onset before the age of eleven: Clinical characteristics of onset and course. Journal ofAutism and Developmental Disorders, 30, 29-38.
14. Frazier, J.A., McClellan, J., Findling, R.L., Vitiello, B., Anderson, R., Zablotsky, B., Williams, E., McNamara, N.K., Jackson, J.A., Ritz, L., Hlastala, S.A., Pierson, L., Varley, J.A., Puglia, M., Maloney, A.E., Ambler, D., Hunt-Harrison, T., Hamer, R.M., Noyes, N., Lieber- man, J.A., & Sikich, L. (2007). Treatment of early- onset schizophrenia spectrum disorders (TEOSS): Demographic and clinical characteristics. Journal of the American Academy ofChild and Adolescent Psychiatry, 46, 979-988.
15. Gordon, C.T., State, R.C., Nelson, J.E., Hamburger, S.D., & Rapoport, J.L. (1993). A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Archives of General Psychiatry, 50, 441-447.
16. Greenhill, L., Kollins, S., Abikoff, H., McCracken, J., Riddle, M., Swanson, J., McGough, J., Wigal, S., Wigal, T., Vitiello, B., Skrobala, A., Posner, K., Ghu- man, J., Cunningham, C., Davies, M., Chuang, S., & Cooper, T. (2006). Efficacy and safety of immediate- release methylphenidate treatment for preschoolers with ADHD. Journal ofthe American Academy ofChild and Adolescent Psychiatry, 45, 1284-1293.
17. Hardy, J. (in press). The genetics and pathogenesis of Alzheimer's disease and related dementias. In N. Wood (ed.), The genetics ofneurological disease. New York: Wiley.
18. Hollon, S.D., Munoz, R.F., Barlow, D.H., Beardslee, W.R., Bell, C.C., Bernal, G., Clarke, G.N., Franciosi, L.P., Kazdin, A.E., Kohn, L., Linehan, M.M., Marko- witz, J.C., Miklowitz, D.J., Persons, J.B., Niederehe, G., & Sommers, D. (2002). Psychosocial intervention development for the prevention and treatment of depression: Promoting innovation and increasing access. Biological Psychiatry, 52, 610-630.
19. Jensen, P.S., Arnold, L.E., Swanson, J.M., Viciello, B, Abikoff, H.B., Greenhill, L.L., Hechtman, L., Hin- shaw, S.P., Pelham, W.E., Wells, K.C., Conners, C.K., Elliott, G.R., Epstein, J.N., Hoza, B., March, J.S., Molina, B.S., Newcorn, J.H., Severe, J.B., Wigal, T., Gibbons, R.D., & Hur, K. (2007). 3-year follow-up of the NIMH MTA study. Journal ofthe American Academy of Child and Adolescent Psychiatry, 46, 9891002.
20. Jensen, P.S., Hinshaw, S.P., Swanson, J.M., Greenhill, L.L., Conners, C.K., Arnold, L.E., Abikoff, H.B., Elliott, G., Hechtman, L., Hoza, B., March, J.S., Newcorn, J. H., Severe, J.B., Vitiello, B., Wells, K., & Wigal, T. (2001). Findings from the NIMH Multi- modal Treatment Study of ADHD (MTA): Implications and applications for primary care providers. Journal of Developmental and Behavioral Pediatrics, 22,60-73.
21. Kilpinen, H., Ylisaukko-Oja, T., Hennah, W., Palo, O.M., Varilo, T., Vanhala, R., Nieminen-Von Wendt, T., Von Wendt, L., Paunio, T., & Peltonen, L. (2008). Association of DISC1 with autism and Asperger syndrome. Molecular Psychiatry, 13, 187-196.
22. Kim-Cohen, J., Moffitt, T.E., Caspi, A., & Taylor, A. (2004). Genetic and environmental processes in young children's resilience and vulnerability to socioeconomic deprivation. Child Development, 75,651-668.
23. Kohler, W. (1949). Problem solving by chimpanzees. In W. Dennis (Ed.), Readings in general psychology (pp. 306-314). New York: Prentice-Hall.
24. Kollins, S., Greenhill, L., Swanson, J., Wigal, S., Abik- off, H., McCracken, J., Riddle, M., McGough, J., Vitiello, B., Wigal, T., Skrobala, A., Posner, K., Ghu- man, J., Davies, M., Cunningham, C., & Bauzo, A. (2006). Rationale, design, and methods of the Preschool ADHD Treatment Study (PATS). Journal of the American Academy of Child and Adolescent Psychiatry, 45, 1275-1283.
25. Kolvin, I. (1971). Studies in the childhood psychoses. I. Diagnostic criteria and classification. British Journal of Psychiatry, 118, 381-384.
26. Kolvin, I., Garside, R.F., & Kidd, J.S. (1971a). Studies in the childhood psychoses. IV. Parental personality and attitude and childhood psychoses. British Journal of Psychiatry, 118, 403-406.
27. Kolvin, I., Humphrey, M., & McNay, A. (1971b). Studies in the childhood psychoses. VI. Cognitive factors in childhood psychoses. British Journal of Psychiatry, 118, 415-419.
28. Kolvin, I., Ounsted, C., Humphrey, M., & McNay, A. (1971c). Studies in the childhood psychoses. II. The phenomenology of childhood psychoses. British Journal of Psychiatry, 118, 385-395.
29. Kolvin, I., Ounsted, C., Richardson, L.M., & Garside, R.F. (1971d). Studies in the childhood psychoses. 3. The family and social background in childhood psychoses. British Journal of Psychiatry, 118, 396-402.
30. Kolvin, I., Ounsted, C., & Roth, M. (1971e). Studies in the childhood psychoses. V. Cerebral dysfunction and childhood psychoses. British Journal ofPsychi-atry, 118, 407-414.
31. Kraepelin, E. (1971). Dementia praecox and paraphrenia (facsimile 1919 edition). Huntington, NY: Robert E. Krieger.
32. Lahuis, B.E., Durston, S., Nederveen, H., Zeegers, M., Palmen, S.J., & Van Engeland, H. (2007). MRI-based morphometry in children with multiple complex developmental disorder, a phenotypically defined subtype of pervasive developmental disorder not otherwise specified. Psychological Medicine, 10 September, 1-7 [Epub ahead of print].
33. Leonard, H.L., Lenane, M.C., Swedo, S.E., Rettew, D.C., & Rapoport, J.L. (1991). A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting). Archives ofGeneral Psychiatry, 48, 821-827.
34. Leonard, H.L., Swedo, S.E., Rapoport, J.L., Koby, E.V., Lenane, M.C., Cheslow, D.L., & Hamburger, S.D. (1989). Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. Archives of General Psychiatry, 46, 1088-1092.
35. Lopez-Ibor, J. (1968). Intravenous infusions of mono- chlorimipramine. Technique and results. Collegium International Psychopharmacology (CINP). Taragona, Spain: Exerpta Medica Foundation, Amsterdam.
36. March, J.S., Silva, S.G., Compton, S., Anthony, G., Deveaugh-Geiss, J., Califf, R., & Krishnan, R. (2004). The Child and Adolescent Psychiatry Trials Network (CAPTN). Journal ofthe American Academy ofChild and Adolescent Psychiatry, 43, 515-518.
37. McClellan, J., Sikich, L., Findling, R.L., Frazier, J.A., Vitiello, B., Hlastala, S.A., Williams, E., Ambler, D., Hunt-Harrison, T., Maloney, A.E., Ritz, L., Anderson, R., Hamer, R.M., & Lieberman, J.A. (2007). Treatment of early-onset schizophrenia spectrum disorders (TEOSS): Rationale, design, and methods. Journal ofthe American Academy ofChild and Adolescent Psychiatry, 46, 969-978.
38. Miller, F., Begbie, M., Giacomini, M., Ahern, C., & Harvey, E. (2006). Redefining disease? The nosologic implications of molecular genetic knowledge Perspectives in Biology and Medicine, 49, 99-114.
39. Moffitt, T.E. (2005). Genetic and environmental influences on antisocial behaviors: Evidence from behavioral-genetic research. Advances in Genetics, 55, 41-104.
40. Nicolson, R., & Rapoport, J.L. (1999). Childhood-onset schizophrenia: Rare but worth studying. Biological Psychiatry, 46, 1418-1428.
41. Poulton, R., Caspi, A., Moffitt, T.E., Cannon, M., Murray, R., & Harrington, H. (2000). Children's self- reported psychotic symptoms and adult schizophren-iform disorder: A 15-year longitudinal study. Archives of General Psychiatry, 57, 1053-1058.
42. Rapoport, J., Elkins, R., & Mikkelsen, E. (1980a). Clinical controlled trial of clorimipramine in adolescents with obsessive-compulsive disorder. Psycho- pharmacology Bulletin, 3, 61-63.
43. Rapoport, J.L., Addington, A.M., Frangou, S., & Psych, M.R. (2005). The neurodevelopmental model of schizophrenia: Update 2005. Molecular Psychiatry, 10, 434-449.
44. Rapoport, J.L., Buchsbaum, M.S., & Weingartner, H. (1980b). Dextroamphetamine: Cognitive and behavioral effects in normal and hyperactive boys and normal adult males. Psychopharmacology Bulletin, 16, 21-23.
45. Rapoport, J.L., Buchsbaum, M.S., Zahn, T.P., Wein- gartner, H., Ludlow, C., & Mikkelsen, E.J. (1978). Dextroamphetamine: Cognitive and behavioral effects in normal prepubertal boys. Science, 199, 560-563.
46. Rapoport, J.L., & Gogtay, N. (2008). Brain neuroplas- ticity in healthy, hyperactive and psychotic children: Insights from neuroimaging. Neuropsychopharmaco- logy Reviews, 33, 181-197.
47. Rapoport, J.L., & Inoff-Germain, G. (2002). Responses to methylphenidate in attention-deficit/hyperactivity disorder and normal children: Update 2002. Journal ofAttention Disorder, 6(Suppl. 1), S57-60.
48. Rapoport, J.L., Ryland, D.H., & Kriete, M. (1992). Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder. Archives of General Psychiatry, 49, 517-521.
49. Richters, J.E., Arnold, L.E., Jensen, P.S., Abikoff, H., Conners, C.K., Greenhill, L.L., Hechtman, L., Hin- shaw, S.P., Pelham, W.E., & Swanson, J.M. (1995). NIMH collaborative multisite multimodal treatment study of children with ADHD: I. Background and rationale. Journal ofthe American Academy ofChild and Adolescent Psychiatry, 34, 987-1000.
50. Robins, L. (1966). Deviant children grown up. Baltimore: The Williams & Wilkins Company.
51. Rutter, M. (1968). Concepts of autism: A review of research. Journal ofChild Psychology and Psychiatry,9, 1-25.
52. Rutter, M. (1972). Childhood schizophrenia reconsidered. Journal ofAutism and Childhood Schizophrenia, 2, 315-337.
53. Rutter, M., Tizard, J., & Whitemore, K. (1970). Education, health and behavior. London: Longman.
54. Rzhetsky, A., Wajngurt, D., Park, N., & Zheng, T. (2007). Probing genetic overlap among complex human phenotypes. Proceedings of the National Academy ofScience U S A, 104, 11694-11699.
55. Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J.P., Greenstein, D., Clasen, L., Evans, A., Giedd, J., & Rapoport, J.L. (2007a). Attention- deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Science U S A, 104, 1964919654.
56. Shaw, P., Gornick, M., Lerch, J., Addington, A., Seal, J., Greenstein, D., Sharp, W., Evans, A., Giedd, J.N., Castellanos, F.X., & Rapoport, J.L (2007b). Polymorphisms of the dopamine d4 receptor, clinical outcome, and cortical structure in attention-deficit/ hyperactivity disorder. Archives of General Psychiatry, 64, 921-931.
57. Shaw, P., Lerch, J., Greenstein, D., Sharp, W., Clasen, L., Evans, A., Giedd, J., Castellanos, F.X., & Rapo- port, J. (2006). Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder. Archives ofGeneral Psychiatry, 63, 540-549.
58. Sporn, A.L., Addington, A.M., Gogtay, N., Ordonez, A.E., Gornick, M., Clasen, L., Greenstein, D., Tossell, J.W., Gochman, P., Lenane, M., Sharp, W.S., Straub, R. E., & Rapoport, J.L. (2004). Pervasive developmental disorder and childhood-onset schizophrenia: Comorbid disorder or a phenotypic variant of a very early onset illness? Biological Psychiatry, 55, 989994.
59. Swedo, S.E., Leonard, H.L., Rapoport, J.L., Lenane, M.C., Goldberger, E.L., & Cheslow, D.L. (1989). Double-blind comparison of clomipramine and des- methylimipramine in the treatment of trichotilloma- nia (hair pulling). New England Journal ofMedicine,321, 497-501.
60. Vaidya, C.J., Bunge, S.A., Dudukovic, N.M., Zalecki, C.A., Elliott, G.R., & Gabrieli, J.D. (2005). Altered neural substrates of cognitive control in childhood ADHD: Evidence from functional magnetic resonance imaging. American Journal ofPsychiatry, 162, 16051613.
61. Vorstman, J.A., Staal, W.G., Van Daalen, E., Van Engeland, H., Hochstenbach, P.F., & Franke, L. (2006). Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism. Molecular Psychiatry, 11, 18-28. Walsh, T., McClellan, J.M., McCarthy, S.E., Addington, A.M., Pierce, S.B., Cooper, G.M., Nord, A.S., Kusen- da, M., Malhotra, D., Bhandari, A., Stray, S.M., Rippey, C.F., Roccanova, P., Makarov, V., Lakshmi, B., Findling, R.L., Sikich, L., Stromberg, T., Merri- man, B., Gogtay, N., Butler, P., Eckstrand, K., Noory, L., Gochman, P., Long, R., Chen, Z., Davis, S., Baker, C., Eichler, E.E., Meltzer, P.S., Nelson, S.F., Singleton, A.B., Lee, M.K., Rapoport, J.L., King, M.-C., & Sebat, J. (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science, 320, 539-543.
62. Weiss, L.A., Shen, Y., Korn, J.M., Arking, D.E., Miller, D.T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M.A., Green, T., Platt, O.S., Ruderfer, D.M., Walsh, C.A., Altshuler, D., Chakravarti, A., Tanzi, R.E., Stefansson, K., Santangelo, S.L., Gusella, J.F., Sklar, P., Wu, B.L., Daly, M.J., & Autism Consortium. (2008). Association between microdeletion and mi- croduplication at 16p11.2 and autism. New England Journal of Medicine, 358, 667-675.
63. Yarrow, M., Campbell, J.D., & Burton, R.V. (1970). Recollections of childhood: A study of retrospective methods. Monographs ofthe Society for Research in Child Development, 35, 1-83.
64. Zoghbi, H.Y. (2003). Postnatal neurodevelopmental disorders: Meeting at the synapse? Science, 302, 826-830.