GABA receptor proteins within lipid rafts in the AY-9944 model of atypical absence seizures

Epilepsia

Volumn 50, Issue 4, 2009, Pages 776-788

  Huo, Jeanne Zhen ^b   Cortez, Miguel A ^a   Snead III, O Carter ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

AY 9944; Chronic atypical absence seizures; GABA A, B receptors; Lipid rafts

Indexed keywords

1,4 BIS(2 CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; FLOTILLIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATYPICAL ABSENCE SEIZURE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EPILEPSY; EPILEPTOGENESIS; FOREBRAIN; LIPID RAFT; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN; CHOLESTEROL; DISEASE MODELS, ANIMAL; EPILEPSY, ABSENCE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; PROTEIN SUBUNITS; PROTEIN TRANSPORT; RATS; RATS, LONG-EVANS; RECEPTORS, GABA; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS; TRANS-1,4-BIS(2-CHLOROBENZAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;

EID: 63849154790     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01903.x     Document Type: Article

References (35)

1. Becher A, White JH, McIlhinney RA 2001) The gamma-aminobutyric acid receptor B, but not the metabotropic glutamate receptor type-1, associates with lipid rafts in the rat cerebellum. J Neurochem 79 : 787 795.
2. Ben-Ari Y 2002) Excitatory actions of GABA during development: the nature of the nurture. Nat Rev Neurosci 3 : 728 739.
3. Besshoh S, Bawa D, Teves L, Wallace MC, Gurd JW 2005) Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brain. J Neurochem 93 : 186 194.
4. Bessoh S, Chen S, Brown JR, Gurd JW 2007) Developmental changes in the association of NMDA receptors with lipid rafts. J Neurosci Res 85 : 1876 1883.
5. Brown DA, London E 1998) Functions of lipid rafts in biological membrane. Annu Rev Cell Dev Biol 14 : 111 136.
6. Bruses JL, Chauvet N, Rutishauser U 2001) Membrane lipid rafts are necessary for the maintenance of the α7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons. J Neurosci 21 : 504 512.
7. Caillard O, McLean HA, Ben-Ari Y, Gaiarsa JL 1998) Ontogenesis of presynaptic GABAB receptor-mediated inhibition in the CA3 region of the rat hippocampus. J Neurophysiol 79 : 1341 1348.
8. Chan KF, Jia Z, Murphy PA, Burnham WM, Cortez MA, Snead OC III. 2004) Learning and memory impairment in rats with chronic atypical absence seizures. Exp Neurol 190 : 328 336.
9. Cortez MA, McKerlie C, Snead OC III. 2001) A model of atypical absence seizures: EEG, pharmacology and developmental characterization. Neurology 56 : 341 349.
10. Cortez MA, Ryan MA, Cunnane S, Snead OC III. 2002) Brain sterols in the AY-9944 model of atypical absence seizures. Epilepsia 43 : 3 8.
11. Cortez MA, Snead OC III. 2006) Pharmacological models of generalized absence seizures in rodents. In Pitkanen A, Schwartzkroin PA, Moshe SL (Eds) Chapter 10: models of seizures and epilepsy. Elsevier, San Diego, pp. 111 126.
12. Crunelli V, Leresche N 2002) Childhood absence epilepsy: genes, channels, neurons and networks. Nat Rev Neurosci 3 : 371 382.
13. Dalskov SM, Immerdal L, Niels-Christiansen LL, Hansen GH, Schousboe A, Danielsen EM 2005) Lipid raft localization of GABA A receptor and Na+, K+-ATPase in discrete microdomain clusters in rat cerebellar granule cells. Neurochem Int 46 : 489 499.
14. Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M 2002) The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. J Neurosci 22 : 7154 7164.
15. Dvornik D, Hill P 1968) Effect of long term administration of AY-9944, an inhibitor of 7-dehydrocholesterol delta 7 reductase, on serum and tissue lipids in rat. J Lipid Res 9 : 5487 5495.
16. Edidin M 2003) The state of lipid rafts: from model membranes to cells. Annu Rev Biophys Biomol Struct 32 : 257 283.
17. Gaiarsa JL, Tseeb V, Ben-Ari Y 1995) Postnatal development of pre- and postsynaptic GABAB-mediated inhibitions in the CA3 hippocampal region of the rat. J Neurophysiol 73 : 246 255.
18. Ganguly K, Schinder AF, Wong ST, Poo MM 2001) GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition. Cell 105 : 521 532.
19. Hering H, Lin CC, Sheng M 2003) Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. J Neurosci 23 : 3262 3271.
20. Keller RK, Arnold TP, Fliesler SJ 2004) Formation of 7- dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome. J Lipid Res 45 : 347 355.
21. Khirug S, Huttu K, Ludwig A, Smirnov S, Voipio J, Rivera C, Kaila K, Khiroug L 2005) Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices. Eur J Neurosci 21 : 899 904.
22. Koyrakh L, Lujan R, Colon J, Karschin C, Kurachi Y, Karschin A, Wickman K 2005) Molecular and cellular diversity of neuronal G-protein-gated potassium channels. J Neurosci 25 : 11468 11478.
23. Nolan M, Bergazar M, Chu B, Cortez MA, Snead OC III. 2005) Clinical and neurophysiological spectrum associated with atypical absence seizures in children with intractable epilepsy. J Child Neurol 20 : 404 410.
24. Owens DF, Kriegstein AR 2002) Is there more to GABA than synaptic inhibition? Nat Rev Neurosci 3 : 715 727.
25. Persad V, Cortez MA, Snead OC III. 2002) A chronic model of atypical absence seizures: studies of developmental and gender sensitivity. Epilepsy Res 48 : 111 119.
26. Pike LJ 2004) Lipid rafts: heterogeneity on the high seas. Biochem J 378 : 281 292.
27. Poulter MO, Ohannesian L, Larmet Y, Feltz P 1997) Evidence that GABAA receptor subunit mRNA expression during development is regulated by GABAA receptor stimulation. J Neurochem 68 : 631 639.
28. Rakheja D, Boriack R (2008) Pre-cholesterol sterols accumulate in lipid rafts of patients with Smith-Lemli-Opitz syndrome and X-linked dominant chondrodysplasia punctata. Pediatr Dev Pathol 11 : 128 132.
29. Ramos B, Lopez-Tellez JF, Vela J, Baglietto-Vargas D, del Rio JC, Ruano D, Gutierrez A, Vitorica J 2004) Expression of alpha 5 GABAA receptor subunit in developing rat hippocampus. Brain Res Dev Brain Res 151 : 87 98.
30. Rivera C, Voipio J, Payne JA, Ruusuvuori E, Lahtinen H, Lamsa K, Pirvola U, Saarma M, Kaila K 1999) The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397 : 251 255.
31. Simons K, Ikonen E 1997) Functional rafts in cell membranes. Nature 387 : 569 572.
32. Simons K, Toomre D 2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1 : 31 39.
33. Simons K, Ehehalt R 2002) Cholesterol, lipid rafts, and disease. J Clin Invest 110 : 597 603.
34. Tóth TI, Bessaïh T, Leresche N, Crunelli V 2007) The properties of reticular thalamic neuron GABA(A) IPSCs of absence epilepsy rats lead to enhanced network excitability. Eur J Neurosci 26 : 1832 1844.
35. Wu Y, Chan KF, Eubanks JH, Guin Ting Wong C, Cortez MA, Shen L, Che Liu C, Perez Velazquez J, Tian Wang Y, Jia Z, Snead OC III. 2007) Transgenic mice over-expressing GABA(B)R1a receptors acquire an atypical absence epilepsy-like phenotype. Neurobiol Dis 26 : 439 451.