Dipeptidyl peptidase (DP) 6 and DP10: Novel brain proteins implicated in human health and disease

Clinical Chemistry and Laboratory Medicine

Volumn 47, Issue 3, 2009, Pages 262-267

  McNicholas, Kym ^a   Chen, Tong ^a   Abbott, Catherine A ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Dipeptidyl peptidase (DP); DP10; DP6; Voltage gated potassium channel

Indexed keywords

DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 10; DIPEPTIDYL PEPTIDASE 6; DIPEPTIDYL PEPTIDASE IV; MESSENGER RNA; SHAL POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ASTHMA; CATALYSIS; CRYSTAL STRUCTURE; DNA POLYMORPHISM; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE ALIGNMENT;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; ASTHMA; DIPEPTIDYL PEPTIDASES; HEALTH; HUMANS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PEPTIDE HYDROLASES; POTASSIUM CHANNELS; RNA, MESSENGER;

EID: 63849152749     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.061     Document Type: Review

References (29)

1. Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S. Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidasefamily. Proc Natl Acad Sci USA 1992;89:197-201.
2. Abbott CA, Gorrell MD. The family of CD26/DPIV and related ectopeptidases. In: Langner J, Ansorge S, editors. Ecto peptidases: CD13/aminopeptidase N and CD26/ dipeptidylpeptidase IV in medicine and biology. New York: Kluwer Academic, 2002;7:171-95.
3. Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B. Differential characterization of three alternative spliced isoforms of DPPX. Brain Res 2006;1094:1-12.
4. Song WJ. Genes responsible for native depolarizationactivated Kq currents in neurons. Neurosci Res 2002; 42:7-14.
5. Jerng HH, Qian Y, Pfaffinger PJ. Modulation of Kv4.2channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J 2004;87:2380-96.
6. Zagha E, Ozaita A, Chang SY, Nadal MS, Lin U, Saganich MJ, et al. DPP10 modulates Kv4-mediated A-type potassium channels. J Biol Chem 2005;280:18853-61.
7. Qi SY, Riviere PJ, Trojnar J, Junien J-L, Akinsanya KO. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. Biochem J 2003;373:179-89.
8. Kin Y, Misumi Y, Ikehara Y. Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein. J Biochem (Tokyo) 2001;129:289-95.
9. Chen T, Ajami K, McCaughan GW, Gai W-P, Gorrell MD, Abbott CA. Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Biochim Biophys Acta 2006;1764:33-43.
10. Yokotani N, Doi K, Wenthold RJ, Wada K. Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. Hum Mol Genet 1993;2:1037-9.
11. Bjelke JR, Christensen J, Branner S, Wagtmann N, Olsen C, Kanstrup AB, et al. Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV. J Biol Chem 2004;279:34691-7.
12. Jerng HH, Lauver AD, Pfaffinger PJ. DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of KvA-based ion channels. Mol Cell Neurosci 2007; 35:604-24.
13. Strop P, Bankovich AJ, Hansen KC, Garcia KC, Brunger AT. Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. J Mol Biol 2004;343:1055-65.
14. Ren X, Hayashi Y, Yoshimura N, Takimoto K. Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels. Mol Cell Neurosci 2005;29:320-32.
15. Li H-L, Qu Y-J, Lu YC, Bondarenko VE, Wang S, Skerrett IM, et al. DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4. Am J Physiol 2006;291:C966-76.
16. Delano WL. The PyMOL molecular graphics system. Palo Alto, CA: DeLano Scientific, 2002.
17. Radicke S, Cotella D, Graf EM, Ravens U, Wettwer E. Expression and function of dipeptidyl-aminopeptidaselike protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. J Physiol (Oxf) 2005;565:751-6.
18. Takimoto K, Hayashi Y, Ren X, Yoshimura N. Species and tissue differences in the expression of DPPY splicing variants. Biochem Biophys Res Commun 2006;348: 1094-100.
19. Schade J, Stephan M, Schmiedl A, Wagner L, Niestroj AJ, Demuth H, et al. Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8/9, and DP10 in allergic responses of the lung in rats. J Histochem Cytochem 2008;56:147-55.
20. Nadal MS, Ozaita A, Amarillo Y, de Miera EV-S, Ma Y, Mo W, et al. The CD26-related dipeptidyl aminopeptidase- like protein DPPX is a critical component of neuronal A-type Kq channels. Neuron 2003;37:449-61.
21. Pioletti M, Findeisen F, Hura GL, Minor DL Jr. Threedimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol 2006;13:987-95.
22. Wang H, Yan Y, Liu Q, Huang Y, Shen Y, Chen L, et al. Structural basis for modulation of Kv4 Kq channels by auxiliary KChIP subunits. Nat Neurosci 2007;10:32-9.
23. Gorrell MD. First bite wcommentx. Nat Struct Biol 2003;10:3-5.
24. de Lecea L, Soriano E, Criado JR, Steffensen SC, Henriksen SJ, Sutcliffe JG. Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity. Brain Res 1994;25:286-96.
25. Chen T, Shen XF, Chegini F, Gai WP, Abbott CA. Molecular characterisation of a novel dipeptidyl peptidase like protein: its pathological link to Alzheimer's disease. Clin Chem Lab Med 2008;46:A13.
26. Cronin S, Berger S, Ding J, Schymick JC, Washecka N, Hernandez DG, et al. A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet 2008;17:768-74.
27. van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Van den Bosch L, et al. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nat Genet 2008;40:29-31.
28. Allen M, Heinzmann A, Noguchi E, Abecasis G, Broxholme J, Ponting CP, et al. Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet 2003;35:258-63.
29. Hough RB, Lengeling A, Bedian V, Lo C, Bucan M. Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase- like protein 6 and causes dysregulation of Kit expression. Proc Natl Acad Sci USA 1998;95:13800-5.