Phosphatase and tensin homolog in cerebral cavernous malformation: A potential role in pathological angiogenesis - Laboratory investigation

Journal of Neurosurgery

Volumn 110, Issue 3, 2009, Pages 530-539

  Zhu, Yuan ^a,c   Peters, Christian ^a   Hallier Neelsen, Monika ^a   Miller, Dorothea ^a,c   Pagenstecher, Axel ^a   Bertalanffy, Helmut ^a,b   Sure, Ulrich ^a,c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Angiogenesis; Cerebral cavernous malformation; Endothelial proliferation; PTEN

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMALL INTERFERING RNA; WORTMANNIN; PTEN PROTEIN, HUMAN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BRAIN TISSUE; CELL CULTURE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CEREBRAL CAVERNOUS MALFORMATION; CLINICAL ARTICLE; CONGENITAL BLOOD VESSEL MALFORMATION; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; FEMALE; GENE SILENCING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; BRAIN ARTERIOVENOUS MALFORMATION; CHEMISTRY; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; BLOTTING, WESTERN; CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PTEN PHOSPHOHYDROLASE;

EID: 63849141605     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2008.7.17626     Document Type: Article

References (28)

1. Bertalanffy H, Benes L, Miyazawa T, Alberti O, Siegel AM, Sure U: Cerebral cavernomas in the adult: review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev 25:1-53, 2002 (Pubitemid 36055919)
2. Brader S, Eccles SA: Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori 90:2-8, 2004 (Pubitemid 38541717)
3. Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, et al: PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 3:117-130, 2003 (Pubitemid 37443385)
4. Greer JM, Wynshaw-Boris A: Pten and the brain: sizing up social interaction. Neuron 50:343-345, 2006
5. Gu J, Tamura M, Yamada KM: Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol 143:1375-1383, 1998 (Pubitemid 28559837)
6. Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, et al: The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev 19:2054-2065, 2005 (Pubitemid 41247962)
7. Huang J, Kontos CD: PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem 277:10760-10766, 2002
8. Jung KH, Chu K, Jeong SW, Park HK, Bae HJ, Yoon BW: Cerebral cavernous malformations with dynamic and progressive course: correlation study with vascular endothelial growth factor. Arch Neurol 60:1613-1618, 2003 (Pubitemid 37443129)
9. Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, et al: Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci U S A 98:11563-11568, 2001 (Pubitemid 32928768)
10. Leslie NR, Downes CP: PTEN: the down side of PI3-kinase signalling. Cell Signal 14:285-295, 2002
11. Ludemann W, Ellerkamp V, Stan AC, Hussein S: De novo development of a cavernous malformation of the brain: signifi- cance of factors with paracrine and endocrine activity: case report. Neurosurgery 50:646-649, 2002 (Pubitemid 36322849)
12. Maehama T, Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378, 1998 (Pubitemid 28268370)
13. Notelet L, Houtteville JP, Khoury S, Lechevalier B, Chapon F: Proliferating cell nuclear antigen (PCNA) in cerebral cavernomas: an immunocytochemical study of 42 cases. Surg Neurol 47:364-370, 1997 (Pubitemid 27157505)
14. Plummer NW, Gallione CJ, Srinivasan S, Zawistowski JS, Louis DN, Marchuk DA: Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations. Am J Pathol 165:1509-1518, 2004 (Pubitemid 39435151)
15. Rothbart D, Awad IA, Lee J, Kim J, Harbaugh R, Criscuolo GR: Expression of angiogenic factors and structural proteins in central nervous system vascular malformations. Neurosurgery 38:915-925, 1996 (Pubitemid 26292027)
16. Seker A, Yildirim O, Kurtkaya O, Sav A, Gunel M, Pamir MN, et al: Expression of integrins in cerebral arteriovenous and cavernous malformations. Neurosurgery 58:159-168, 2006 (Pubitemid 43053726)
17. Shenkar R, Sarin H, Awadallah NA, Gault J, Kleinschmidt-DeMasters BK, Awad IA: Variations in structural protein expression and endothelial cell proliferation in relation to clinical manifestations of cerebral cavernous malformations. Neurosurgery 56:343-354, 2005 (Pubitemid 40204962)
18. Sure U, Butz N, Schlegel J, Siegel A, Mennel HD, Bien S, et al: Endothelial proliferation, neoangiogenesis and potential de novo generation of cerebral vascular malformations. J Neurosurg 94:972-977, 2001 (Pubitemid 32799598)
19. Sure U, Freman S, Bozinov O, Benes L, Siegel AM, Bertalanffy H: Biological activity of adult cavernous malformations: a study of 56 patients. J Neurosurg 102:342-347, 2005 (Pubitemid 43194086)
20. Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM: PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 274:20693-20703, 1999 (Pubitemid 129519557)
21. Tang Y, Eng C: PTEN autoregulates its expression by stabilization of p53 in a phosphatase-independent manner. Cancer Res 66:736-742, 2006 (Pubitemid 43165936)
22. Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, et al: E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. Mol Cell Biol 27:65-78, 2007 (Pubitemid 46013233)
23. Uranishi R, Baev NI, Ng PY, Kim JH, Awad IA: Expression of endothelial cell angiogenesis receptors in human cerebrovascular malformations. Neurosurgery 48:359-367, 2001 (Pubitemid 32164876)
24. Zawistowski JS, Serebriiskii IG, Lee MF, Golemis EA, Marchuk DA: KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. Hum Mol Genet 11:389-396, 2002
25. Zhang J, Clatterbuck RE, Rigamonti D, Chang DD, Dietz HC: Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation. Hum Mol Genet 10:2953-2960, 2001 (Pubitemid 34030926)
26. Zhao Y, Tan YZ, Zhou LF, Wang HJ, Mao Y: Morphological observation and in vitro angiogenesis assay of endothelial cells isolated from human cerebral cavernous malformations. Stroke 38:1313-1319, 2007
27. Zhu Y, Hoell P, Ahlemeyer B, Krieglstein J: PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis 11:197-207, 2006 (Pubitemid 43291020)
28. Zhu Y, Hoell P, Ahlemeyer B, Sure U, Bertalanffy H, Krieglstein J: Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease. Neurochem Int 50:507-516, 2007 (Pubitemid 46186601)