Immunohistochemical studies of trophoblastic tumors

American Journal of Surgical Pathology

Volumn 33, Issue 4, 2009, Pages 633-638

  Kalhor, Neda ^a   Ramirez, Pedro T ^a   Deavers, Michael T ^a   Malpica, Anais ^a   Silva, Elvio G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cervical carcinoma; Choriocarcinoma; ETT; Immunohistochemistry; Intermediate trophoblastic tumors; PSTT; Squamous carcinoma

Indexed keywords

TUMOR MARKER;

ADENOSQUAMOUS CARCINOMA; ARTICLE; CHORIOCARCINOMA; DIFFERENTIAL DIAGNOSIS; ENZYME IMMUNOASSAY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; SQUAMOUS CELL CARCINOMA; TROPHOBLAST; TROPHOBLASTIC TUMOR; UTERUS CANCER;

CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; CHORIOCARCINOMA; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; TROPHOBLASTIC NEOPLASMS; TROPHOBLASTS; TUMOR MARKERS, BIOLOGICAL; UTERINE NEOPLASMS;

EID: 63849125311     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318191f2eb     Document Type: Article

References (26)

1. Chang Y, Chang T, Hsueh S, et al. Prognostic factors and treatment for placental site trophoblastic tumor-report of 3 cases and analysis of 88 cases. Gynecol Oncol. 1999;73:216-222.
2. Duncan D, Mazur M. Trophoblastic tumors: Ultrastructural comparison of choriocarcinoma and placental-site trophoblastic tumor. Hum Pathol. 1989;20:370-381.
3. Escobar P, Lurain J, Singh D, et al. Treatment of high-risk gestational trophoblastic neoplasia with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine chemotherapy. Gynecol Oncol. 2003;91:552-557.
4. Fadare O, Parkash V, Carcangiu M, et al. Epithelioid trophoblastic tumor: Clinicopathological features with an emphasis on uterine cervical involvement. Mod Pathol. 2006;19:75-82.
5. Fukunaga M, Ushigome S. Malignant trophoblastic tumors: Immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. Hum Pathol. 1993;24: 1098-1106.
6. Gillespie A, Liyim D, Goepel J, et al. Placental site trophoblastic tumor: A rare but potentially curable cancer. Br J Cancer. 2000;82: 1186-1190.
7. Hoekstra A, Keh P, Lurain J. Placental site trophoblastic tumor: A review of 7 cases and their implications for prognosis and treatment. J Reprod Med. 2004;49:447-452.
8. Kurman R. The morphology, biology, and pathology of intermediate trophoblast: A look back to the present. Hum Pathol. 1991; 22:847-855.
9. Kurman R, Young R, Norris H, et al. Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placental and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumors. Int J Gynecol Pathol. 1984;3:101-121.
10. Leiserowitz G, Webb M. Treatment of placental site trophoblastic tumor with hysterotomyand uterine reconstruction. Obstet Gynecol. 1996;88:696-699.
11. Lurain J. Pharmacotherapy of gestational trophoblastic disease. Expert Opin Pharmacother. 2003;4:2005-2017.
12. Mao TL, Kurman RJ, Jeng YM, et al. HSD3B1 as a novel trophoblast- associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions. Am J Surg Pathol. 2008;32:236-242.
13. Mao TL, Seidman J, Kurman RJ, et al. Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor-an aid in differential diagnosis. Am J Surg Pathol. 2006;30:1105-1110.
14. Ohira S, Yamazaki T, Hatano H, et al. Epithelioid trophoblastic tumor metastatic to the vagina: An immunohistochemical and ultrastructural study. Int J Gynecol Pathol. 2000;19:381-386.
15. Ordi J, Romagosa C, Tavassoli F, et al. CD10 expression in epithelial tissues and tumors of the gynecologic tract: A useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol. 2003;27:178-186.
16. Peng L, Huang Y, Jin F, et al. Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1. Mol Endocrinol. 2004;18:2049-2060.
17. Ramondetta L, Silva E, Levenback C, et al. Mixed choriocarcinoma in a postmenopausal patient. Int J Gynecol Pathol. 2002;12:312-316.
18. Shih IEM. Gestational trophoblastic neoplasia-pathogenesis and potential therapeutic targets. Lancet Oncol. 2007;8:642-650.
19. Shih I, Kurman R. Epithelioid trophoblastic tumor: A neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol. 1998;22: 1393-1403.
20. Shih I, Kurman R. Immunohistochemical localization of inhibinalpha in the placenta and gestational trophoblastic lesions. Int J Gynecol Pathol. 1999;18:144-150.
21. Shih I, Kurman R. p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. Am J Surg Pathol. 2004; 28:1177-1183.
22. Silva E, Tornos C, Lage J, et al. Multiple nodules of intermediate trophoblast following hydatidiform moles. Int J Gynecol Pathol. 1993;12:324-332.
23. Singer G, Kurman R, McMaster M, et al. HLA-G immunoreactivity is specific for intermediate trophoblast in gestational trophoblastic disease and can serve as a useful marker in differential diagnosis. Am J Surg Pathol. 2002;26:914-920.
24. Lee Y, Kim KR, McKeon F, et al. A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression. Hum Pathol. 2007;38:1003-1013.
25. Yeh I, O'Connor D, Kurman R. Intermediate trophoblast: Further immunocytochemical characterization. Mod Pathol. 1990;3: 282-287.
26. Young R, Kurman R, Scully R. Proliferations and tumors of intermediate trophoblast of the placental site. Semin Diagn Pathol. 1988;5:223-237.