Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor - An aid in differential diagnosis

American Journal of Surgical Pathology

Volumn 30, Issue 9, 2006, Pages 1105-1110

  Mao, Tsui Lien ^a   Seidman, Jeff D ^b   Kurman, Robert J ^a   Shih, Ie Ming ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b WASHINGTON HOSPITAL CENTER   (United States)

Author keywords

Cervical squamous carcinoma; Cyclin E; Epithelioid trophoblastic tumor; p16; Placental site nodule

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN E; PROTEIN P16;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; EPITHELIOID TROPHOBLASTIC TUMOR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MORPHOLOGY; PLACENTA; SENSITIVITY AND SPECIFICITY; SQUAMOUS CELL CARCINOMA; STAINING; TROPHOBLASTIC TUMOR; TUMOR DIAGNOSIS; UTERINE CERVIX CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CYCLIN E; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENES, P16; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; PLACENTA; PREGNANCY; TROPHOBLASTIC NEOPLASMS; UTERINE CERVICAL NEOPLASMS; UTERINE NEOPLASMS;

EID: 33748062635     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000209854.28282.87     Document Type: Article

References (24)

1. Bamberger AM, Aupers S, Milde-Langosch K, et al. Expression pattern of the cell cycle promoter cyclin e in benign extravillous trophoblast and gestational trophoblastic lesions: correlation with expression of Ki-67. Int J Gynecol Pathol. 2003;22:156-161.
2. Budwit-Novotny DA, McCarty KS, Cox EB, et al. Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody. Cancer Res. 1986;46:5419-5425.
3. Courjal F, Louason G, Speiser P, et al. Cyclin gene amplification and overexpression in breast and ovarian cancers: evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors. Int J Cancer. 1996;69:247-253.
4. Dellas A, Schultheiss E, Leivas MR, et al. Association of p27Kip1, cyclin E and c-myc expression with progression and prognosis in HPV-positive cervical neoplasms. Anticancer Res. 1998;18:3991-3998.
5. Hamazaki S, Nakamoto S, Okino T, et al. Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions. Hum Pathol. 1999;30:1321-1327.
6. Ito K, Sasano H, Yoshida Y, et al. Immunohistochemical study of cyclins D and E and cyclin dependent kinase (cdk) 2 and 4 in human endometrial carcinoma. Anticancer Res. 1998;18:1661-1664.
7. Ito R, Yasui W, Ogawa Y, et al. Reduced expression of cyclin-dependent kinase inhibitor p27(Kip1) in oral malignant tumors. Pathobiology. 1999;67:169-173.
8. Koff A, Cross F, Fisher A, et al. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell. 1991;66:1217-1228.
9. Lessey BA, Castelbaum AJ, Wolf L, et al. Use of integrins to date the endometrium. Fertil Steril. 2000;73:779-787.
10. Lin L, Prescott MS, Zhu Z, et al. Identification and characterization of a 19q12 amplicon in esophageal adenocarcinomas reveals cyclin E as the best candidate gene for this amplicon. Cancer Res. 2000;60:7021-7027.
11. Ohtsubo M, Theodoras AM, Schumacher J, et al. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol. 1995;15:2612-2624.
12. Oldt RJ 3rd, Kurman RJ, Shih Ie M. Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin. Am J Pathol. 2002;161:1033-1037.
13. Resnitzky D, Gossen M, Bujard H, et al. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol. 1994;14:1669-1679.
14. Richter JWU, Kononen J, Fijan A, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol. 2000;157:787-794.
15. Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol. 1998;153:1741-1748.
16. Schraml P, Bucher C, Bissig H, et al. Cyclin E overexpression and amplification in human tumours. J Pathol. 2003;200:375-382.
17. Shih I-M, Kurman RJ. Epithelioid trophoblastic tumor - a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol. 1998;22:1393-1403.
18. Shih IM, Kurman RJ. The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int J Gynecol Pathol. 2001;20:31-47.
19. Shih I-M, Kurman RJ. Molecular basis of gestational trophoblastic diseases. Curr Mol Med. 2002;2:1-12.
20. Shih IM, Kurman RJ. p63 Expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. Am J Surg Pathol. 2004;28:1177-1183.
21. Shih I-M, Mazur MT, Kurman RJ. Gestational trophoblastic disease. In: Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract. 5th ed. New York: Springer-Verlag; 2002:1193-1247.
22. Shih IM, Seidman JD, Kurman RJ. Placental site nodule and characterization of distinctive types of intermediate trophoblast. Hum Pathol. 1999;30:687-694.
23. Singer G, Kurman RJ, McMaster M, et al. HLA-G immunoreactivity is specific for intermediate trophoblast in gestational trophoblastic disease and can serve as a useful marker in differential diagnosis. Am J Surg Pathol. 2002;26:914-920.
24. Yasui W, Naka K, Suzuki T, et al. Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma. Oncol Rep. 1999;6:983-987.