Commentary: Antioxidants for cancer: New tricks for an old dog?

Oncologist

Volumn 14, Issue 3, 2009, Pages 213-215

  Sharifi, Nima ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; REACTIVE OXYGEN METABOLITE; RETINOL;

ANTIOXIDANT ACTIVITY; CANCER SUSCEPTIBILITY; CELL ACTIVITY; DNA DAMAGE; GENETIC POLYMORPHISM; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NOTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL;

ANTIOXIDANTS; HUMANS; NEOPLASMS; REACTIVE OXYGEN SPECIES;

EID: 63849093678     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2008-0219     Document Type: Note

References (21)

1. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad SciUSA 1978;75:4538-4542.
2. Creagan ET, Moertel CG, O'Fallon JR et al. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 1979;301:687-690.
3. Moertel CG, Fleming TR, Creagan ET et al. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med 1985;312:137-141.
4. Padayatty SJ, Sun H, Wang Y et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 2004;140:533-537.
5. van Zandwijk N, Dalesio O, Pastorino U et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. J Natl Cancer Inst 2000;92:977-986.
6. Aitio ML. N-acetylcysteine-passe-partout or much ado about nothing? Br J Clin Pharmacol 2006;61:5-15.
7. Lawenda BD, Kelly KM, Ladas EJ et al. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 2008;100:773-783.
8. Ladas EJ, Jacobson JS, Kennedy DD et al. Antioxidants and cancer therapy: a systematic review. J Clin Oncol 2004;22:517-528.
9. Gao P, Zhang H, Dinavahi R et al. HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 2007;12:230-238.
10. Ishikawa K, Takenaga K, Akimoto M et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008;320:661-664.
11. Chen Q, Espey MG, Sun AY et al. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci USA 2008;105:11105-11109.
12. Hahn WC, Weinberg RA. Rules for making human tumor cells. N Engl J Med 2002;347:1593-1603.
13. D'Autréaux B, Toledano MB. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 2007; 8:813-824.
14. Benassi B, Fanciulli M, Fiorentino F et al. c-Myc phosphorylation is required for cellular response to oxidative stress. Mol Cell 2006;21:509-519.
15. Semenza GL. Life with oxygen. Science 2007;318:62-64.
16. Best CJ, Gillespie JW, Yi Y et al. Molecular alterations in primary prostate cancer after androgen ablation therapy. Clin Cancer Res 2005;11:6823-6834.
17. Sharifi N, Hurt EM, Thomas SB et al. Effects of manganese superoxide dis-mutase silencing on androgen receptor function and gene regulation: implications for castration-resistant prostate cancer. Clin Cancer Res 2008; 14:6073-6080.
18. Fagerholm R, Hofstetter B, Tommiska J et al. NAD(P)H:quinone oxi-doreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet 2008;40:844-853.
19. Lippman SM, Klein EA, Goodman PJ et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009;301:39-51.
20. Gaziano JM, Glynn RJ, Christen WG et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA 2009;301:52-62.
21. Lin J, Cook NR, Albert C et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009;101:14-23.