Visceral fat accumulation is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients

European Journal of Clinical Investigation

Volumn 39, Issue 5, 2009, Pages 368-374

  Anan, F ^a,b   Masaki, T ^b   Eto, T ^a   Iwao, T ^a   Shimomura, T ^a   Umeno, Y ^a   Eshima, N ^b   Saikawa, T ^b   Yoshimatsu, H ^b  

^a OITA RED CROSS HOSPITAL   (Japan)

^b OITA UNIVERSITY   (Japan)

Author keywords

Insulin resistance; Type 2 diabetes mellitus; Visceral fat accumulation; White matter lesion

Indexed keywords

ALPHA GLUCOSIDASE INHIBITOR; ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOREACTIVE INSULIN; PIOGLITAZONE; SULFONYLUREA;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY FAT DISTRIBUTION; BODY MASS; BRAIN DAMAGE; CIGARETTE SMOKING; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSLIPIDEMIA; ESSENTIAL HYPERTENSION; FEMALE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INTRAABDOMINAL FAT; JAPANESE; LIPID METABOLISM; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; STATISTICAL SIGNIFICANCE; STROKE; UMBILICUS; WHITE MATTER; WHITE MATTER LESION;

AGED; ARTERIOSCLEROSIS; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RISK FACTORS; STROKE;

EID: 63849083592     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2009.02103.x     Document Type: Article

References (37)

1. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger's report. Stroke 1995 26 : 1293 301.
2. Wong TY, Klein R, Sharrett AR, Couper DJ, Klein BE, Liao DP et al. ARIC Investigators. Atheroslerosis Risk in Communities Study. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 2002 288 : 67 74.
3. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM. Rotterdam Scan Study. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke 2003 34 : 1126 9.
4. Boyko EJ, Fujimoto WY, Leonetti DL, Newell-Morris L. Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Diabetes Care 2000 23 : 465 71.
5. Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE et al. Visceral adiposity and the prevalence of hypertension in Japanese-Americans. Circulation 2003 108 : 1718 23.
6. Matsuzawa Y. Pathophysiology and molecular mechanisms of visceral fat syndrome: The Japanese experience. Diabetes Metab Rev 1997 13 : 313.
7. Fujimoto W, Bergstrom R, Boyko E, Chen KW, Leonetti DL, Newell-Morris L et al. Visceral adiposity and incident coronary heart disease in Japanese-American men: the 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. Diabetes Care 1999 22 : 1808 12.
8. St-Pierre J, Lemieux I, Vohl MC, Perron P, Tremblay G, Després JP et al. Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease. Am J Cardiol 2002 90 : 15 8.
9. Raji A, Seely EW, Arky RA, Simonson DC. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 2001 86 : 5366 71.
10. Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E et al. Metabolic effects of visceral fat accumulation in type 2 diabetes mellitus. J Clin Endocrinol Metab 2002 87 : 5098 103.
11. Reaven GM. Role of insulin resistance in human disease. Diabetes 1998 37 : 1595 607.
12. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991 14 : 173 94.
13. Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S. Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based study. J Am Coll Cardiol 2007 49 : 2112 9.
14. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G et al. ESH-ESC Task Force on the Management of Arterial Hypertension. ESH-ESC practice guidelines for the management of arterial hypertension: ESH-ESC task force on the management of arterial hypertension. J Hypertens 2007 25 : 1751 62.
15. Friedwald WT, Levi RI, Fredrickson DC. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the ultracentrifuge. Clin Chem 1972 18 : 499 502.
16. Anan F, Masaki T, Tatsukawa T, Nagano S, Oribe M, Eshima N et al. The role of homocysteine as a significant risk factor for white matter lesions in Japanese women with rheumatoid arthritis. Metabolism 2009 58 : 69 73.
17. Liao D, Sloan RP, CaWMLo WE, Folsom AR, Liese AD, Evans GW et al. Multiple metabolic syndrome is associated with lower heart rate variability. The Atherosclerosis Risk in Communities Study. Diabetes Care 1998 21 : 2116 22.
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 : 412 9.
19. Taniguchi A, Fukushima M, Sakai M, Miwa K, Makita T, Nagata I et al. Remnant-like particle cholesterol, triglyceride, and insulin resistance in nonobese Japanese type 2 diabetic patients. Diabetes Care 2000 23 : 1766 9.
20. Imai E, Matsuo S, Makino H, Watanabe T, Akizawa T, Nitta K et al. Chronic kidney disease Japan cohort (CKD-JAC) study: design and methods. Hypertens Res 2008 31 : 1101 7.
21. Yoshizumi T, Nakamura T, Yamane M, Islam AH, Menju M, Yamasaki K et al. Abdominal fat:standardized technique for measurement at CT. Radiology 1999 211 : 283 6.
22. 40K. Int J Obes 1988 12 : 249 66.
23. The Examination Committee of Criteria for 'Obesity Disease' in Japan, Japan Society for the Study of Obesity. New criteria for 'Obesity Disease' in Japan. Circ J 2002 66 : 987 92.
24. Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975 12 : 189 98.
25. Breteler MM, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JH et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994 44 : 1246 52.
26. Shimada K, kawamoto A, Matsubayashi K, Ozawa T. Silent cerebrovascular disease in the elderly. Correlation with ambulatory pressure. Hypertension 1990 16 : 692 9.
27. Sierra C, de la Sierra A, Mercader J, Gómez-Angelats E, Urbano-Márquez A, Coca A. Silent cerebral white matter lesions in middle-aged essential hypertensive patients. J Hypertens 2002 20 : 519 24.
28. Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F et al. Obesity and body fat distribution induce endothelial dysfunction by oxidant stress: protective effect of vitamin C. Diabetes 2001 50 : 159 65.
29. Stout RW. Insulin and atheroma: 20-yr perspective. Diabetes Care 1990 13 : 631 54.
30. Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 2000 101 : 676 81.
31. Steinberg HO, Paradisi G, Hook G, Crowder K, Cronin J, Baron AD. Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes 2000 49 : 1231 8.
32. Arcaro G, Cretti A, Balzano S, Lechi A, Muggeo M, Bonora E et al. Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 2002 105 : 576 82.
33. Wada M, Nagasawa H, Kurita K, Koyama S, Arawaka S, Kawanami T et al. Microalbuminuria is a risk factor for cerebral small vessel disease in community-based elderly subjects. J Neurol Sci 2007 255 : 27 34.
34. Lender D, Arauz-Pacheco C, Breen L, Mora-Mora P, Ramirez LC, Raskin P. A double blind comparison of the effects of amlodipine and enalapril on insulin sensitivity in hypertensive patients. Am J Hypertens 1999 12 : 298 303.
35. Anan F, Takahashi N, Ooie T, Yufu K, Hara M, Nakagawa M et al. Effects of valsartan and perindopril combination therapy on left ventricular hypertrophy and aortic stiffness in patients with essential hypertension. Eur J Clin Pharmacol 2005 61 : 353 9.
36. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death cardiovascular events, and hospitalization. N Engl J Med 2004 351 : 1296 305.
37. Nakayama S, Metoki H, Terawaki H, Ohkubo T, Kikuya M, Sato T et al. Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese Population-the Ohasama study. Nephrol Dial Transplant 2007 22 : 1910 5.