Calculation of QT shift in non clinical safety pharmacology studies

Journal of Pharmacological and Toxicological Methods

Volumn 59, Issue 2, 2009, Pages 73-85

  Champeroux, Pascal ^a   Martel, Eric ^a   Fowler, John Sinclair Lawrence ^a   Maurin, Anne ^a   Sola, Marie Laure ^a   Jude, Sébastien ^a   Elamrani, Francine ^a   Weyn, Andrée Anne ^a   Laveissiere, Arnaud ^a   Lala, Patricia ^a   Richard, Serge ^a  

^a CERB   (France)

Author keywords

Beagle dogs; Cynomolgus monkeys; Methods; Proarrhythmic risk; QT correction; QT prolongation; Safety pharmacology; Terfenadine

Indexed keywords

DOFETILIDE; SOTALOL; TERFENADINE; THIORIDAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; EXPERIMENTAL DOG; EXPERIMENTAL MONKEY; FEMALE; MALE; NONHUMAN; QT PROLONGATION; SINGLE DRUG DOSE; TACHYCARDIA; TELEMETRY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; DOGS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; LONG QT SYNDROME; MACACA FASCICULARIS; MALE; MODELS, STATISTICAL; PHENETHYLAMINES; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SOTALOL; SULFONAMIDES; TELEMETRY; TERFENADINE; THIORIDAZINE;

ANIMALIA; CANIS FAMILIARIS; MACACA FASCICULARIS;

EID: 63749111515     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2008.11.001     Document Type: Article

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