Assessment of drug-induced QT prolongation: To bin or not to bin?

Clinical Pharmacology and Therapeutics

Volumn 77, Issue 4, 2005, Pages 241-246

  Malik, Marek ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; UNCLASSIFIED DRUG;

CARDIOTOXICITY; CIRCADIAN RHYTHM; CONFIDENCE INTERVAL; ELECTROCARDIOGRAM; HEART PROARRHYTHMIA; HEART RATE; HOLTER MONITORING; HUMAN; HYSTERESIS; NOTE; PRIORITY JOURNAL; QT PROLONGATION; RR INTERVAL; SIGNAL AVERAGED ELECTROCARDIOGRAPHY; SINUS ARRHYTHMIA; STATISTICAL SIGNIFICANCE; TORSADE DES POINTES;

ELECTROCARDIOGRAPHY; ELECTROCARDIOGRAPHY, AMBULATORY; HUMANS; LONG QT SYNDROME; PHARMACEUTICAL PREPARATIONS;

EID: 16344367621     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2004.11.004     Document Type: Note

References (10)

1. International Conference on Harmonisation. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs. Available from: URL: http://www.fda.gov/cder/calendar/meeting/qt4jam.pdf.
2. R.R. Fenichel, M. Malik, C. Antzelevitch, M. Sanguinetti, D.M. Roden, S.G. Priori Drug-induced torsades de pointes and implications for drug development J Cardiovasc Electrophysiol 15 2004 475 495
3. P.M. Rautaharju, Z.M. Zhang Linearly scaled, rate-invariant normal limits for QT interval eight decades of incorrect application of power functions J Cardiovasc Electrophysiol 13 2002 1211 1218
4. V.N. Batchvarov, A. Ghuran, P. Smetana, K. Hnatkova, M. Harries, P. Dilaveris QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability Am J Physiol Heart Circ Physiol 282 2002 H2356-63
5. M. Malik Problems of heart rate correction in assessment of drug-induced QT interval prolongation J Cardiovasc Electrophysiol 12 2001 411 420
6. M. Malik, K. Hnatkova, V. Batchvarov Differences between study-specific and subject-specific heart rate corrections of the QT interval in investigations of drug induced QTc prolongation Pacing Clin Electrophysiol 27 2004 791 800
7. F. Extramiana, P. Maison-Blanche, M.-J. Cabanis, C. Ortemann-Renon, P. Beaufils, A. Leenhardt Clinical assessment of drug-induced QT prolongation in association with heart rate changes Clin Pharmacol Ther 77 2005 247 258
8. C.P. Lau, A.R. Freeman, S.J. Fleming, M. Malik, A.J. Camm, D.E. Ward Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate Cardiovasc Res 22 1988 67 72
9. E. Pueyo, P. Smetana, P. Caminal, A. Bayes de Luna, M. Malik, P. Laguna Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction IEEE Trans Biomed Eng 51 2004 1511 1520
10. M. Malik The impression in heart rate correction may lead to artificial observations of drug induced QT interval changes Pacing Clin Electrophysiol 25 2002 209 216