Activation of telomerase in Glioma cells by human cytomegalovirus: Another piece of the puzzle

Journal of the National Cancer Institute

Volumn 101, Issue 7, 2009, Pages 441-443

  Cinatl Jr , Jindrich ^a,c   Nevels, Michael ^b   Paulus, Christina ^b   Michaelis, Martin ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^c Institut fur Forensische Medizin   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE REVERSE TRANSCRIPTASE; IE1 PROTEIN, CYTOMEGALOVIRUS; IMMEDIATE EARLY PROTEIN; TELOMERASE; TERT PROTEIN, HUMAN;

CARCINOGENESIS; EDITORIAL; ENZYME ACTIVATION; FIBROBLAST; GENE EXPRESSION; GLIOMA CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA; VIRUS INFECTION; CYTOMEGALOVIRUS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GLIOBLASTOMA; GLIOMA; HUMAN; METABOLISM; NOTE; TUMOR CELL LINE; TUMOR VIRUS; VIROLOGY;

CELL LINE, TUMOR; CYTOMEGALOVIRUS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; GLIOMA; HUMANS; IMMEDIATE-EARLY PROTEINS; ONCOGENIC VIRUSES; TELOMERASE;

EID: 63649134310     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djp047     Document Type: Editorial

References (31)

1. Strååt K, Liu C, Rahbar A, et al. Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst. 2009;101(7):488-497.
2. Fuccillo DA, Sever JL, Moder FL, Chen TC, Catalano LW, Johnson LD. Cytomegalovirus antibody in patients with carcinoma of the uterine cervix. Obstet Gynecol. 1971 ;38(4):599-601.
3. Michaelis M, Doerr HW, Cinatl J Jr. The story of human cytomegalovirus and cancer: increasing evidence and open questions. Neoplasia. 2009; 11(1): 1-9.
4. Söderberg-Nauclér C. HCMV microinfections in inflammatory diseases and cancer. J Clin Virol..41(3):218-223.
5. Ohagen A, Gibaja V, Horrigan J, et al. Induction of latent human cytomegalovirus by conventional gamma irradiation and prevention by treatment with INACTINE PEN110. Vox Sang. 2004;87(1):1-9.
6. Kuo CP, Wu CL, Ho HT, Chen CG, Liu SI, Lu YT. Detection of cytomegalovirus reactivation in cancer patients receiving chemotherapy. Clin Microbiol Infect. 2008;14(3):221-227.
7. Mitchell DA, Xie W, Schmittling R, et al. Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. Neuro Oncol. 2008;10(1):10-18.
8. Geder KM, Lausch R, O'Neill F, Rapp F. Oncogenic transformation of human embryo lung cells by human cytomegalovirus. Science. 1976; 192(4244):1134-1137.
9. Geder L, Kreider J. Human cells transformed in vitro by human cytomegalovirus: tumorigenicity in athymic nude mice. ? Natl Cancer Inst. 1977;58(4):1003-1009.
10. Cinatl J Jr, Cinatl J, Vogel JU, Rabenau H, Komhuber B, Doerr HW. Modulatory effects of human cytomegalovirus infection on malignant properties of cancer cells. Intervirology. 1996;39(4):259-269.
11. Cinatl J Jr, Kotchetkov R, Scholz M, et al. Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53. AmJ Pathol. 1999; 155(1):285-292.
12. Lee K, Jeon K, Kim JM, et al. Downregulation of GFAP, TSP-1p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus. Glia. 2005;51(1): 1-12.
13. Luo MH, Fortunato EA. Long-term infection and shedding of human cytomegalovirus in T98G glioblastoma cells. J Virol. 2007;81(19):10424- 10436.
14. Cobbs CS, Soroceanu L, Denham S, et al. Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. ? Neurooncol. 2007;85(3):271-280.
15. Cobbs CS, Soroceanu L, Denham S, Zhang W, Kraus MH. Modulation of oncogenic phenotype in human glioma cells by cytomegalovirus IE1-mediated mitogenicity. Cancer Res. 2008;68(3):724-730.
16. Maussang D, Verzijl D, van Walsům M, et al. Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis. Proc Natl Acad Sci USA. 2006;103(35):13068-13073.
17. Cobbs CS, Harkins L, Samanta M, et al. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res. 2002;62(12):3347-3350.
18. Scheurer ME, Bondy ML, Aldape KD, Albrecht T, El-Zein R. Detection of human cytomegalovirus in different histological types of gliomas. Acta Neuropathol. 2008;116(1):79-86.
19. Lau SK, Chen YY, Chen WG, et al. Lack of association of cytomegalovirus with human brain tumors. Mod Pathol. 2005; 18(6):838-843.
20. Poltermann S, Schlehofer B, Steindorf K, Schnitzler P, Geletneky K, Schlehofer JR. Lack of association of herpesviruses with brain tumors. JNeurovirol. 2006;12(2):90-99.
21. Sabatier J, Uro-Coste E, Pommepuy I. Detection of human cytomegalovirus genome and gene products in central nervous system tumours. BrJ Cancer. 92(4):747-750.
22. Stinski MF, Isomura H. Role of the cytomegalovirus major immediate early enhancer in acute infection and reactivation from latency. Med Microbiol Immunol. 2008;197(2):223-231.
23. Nevels M, Paulus C, Shenk T. Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. Proc Natl Acad Sci USA. 2004; 101(49):17234-17239.
24. Bellon M, Nicot C. Regulation of telomerase and telomeres: human tumor viruses take control. J Natl Cancerlnst. 2008;100(2):98-108.
25. Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer. 2008; 8(3):167-179.
26. Boehm JS, Hahn WC. Immortalized cells as experimental models to study cancer. Cytotechnology. 2004;45(1-2)47-59.
27. Mimeault M, Batra SK. Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications (published online ahead of print). Ageing Res Rev. 2008. doi:10.1016/j.arr.2008.12.001.
28. Bollmann FM. The many faces of telomerase: emerging extratelomeric effects. Bioessays. 2008;30(8):728-732.
29. Cinatl J Jr, Cinatl J, Vogel JU, et al. Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells. Cancer Res. 1998;58(2):367-372.
30. Scholz M, Doerr HW, Cinatl J Jr. Inhibition of cytomegalovirus immediate early gene expression: a therapeutic option? Antiviral Res. 2001;49(3):129-145.
31. Miller G. Brain cancer. A viral link to glioblastoma? Science. 2009;323(5910):30-31.