Dioxin-induced up-regulation of the active form of vitamin D is the main cause for its inhibitory action on osteoblast activities, leading to developmental bone toxicity

Toxicology and Applied Pharmacology

Volumn 236, Issue 3, 2009, Pages 301-309

  Nishimura, Noriko ^a   Nishimura, Hisao ^b   Ito, Tomohiro ^a   Miyata, Chie ^a,c   Izumi, Keiko ^d   Fujimaki, Hidekazu ^a   Matsumura, Fumio ^e  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b Japan   (Japan)

^c AZABU UNIVERSITY   (Japan)

^d FINETEC   (Japan)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; 25 hydroxyvitamin D3 1 hydroxylase; Bone mineralization; FGF 23; Vitamin D

Indexed keywords

ALKALINE PHOSPHATASE; CALBINDIN; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; CALCIUM; COLLAGEN TYPE 1; DIOXIN; FIBROBLAST GROWTH FACTOR 23; GENE PRODUCT; OSTEOCALCIN; OXYGENASE; PARATHYROID HORMONE; PHOSPHORUS; PROTEIN NCX1; PROTEIN PMCA1B; RETINOID X RECEPTOR; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 5; VITAMIN D; VITAMIN D 24 HYDROXYLASE; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE INJURY; BONE MINERALIZATION; BONE TOXICITY; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CORTICAL BONE; FEMALE; GENE EXPRESSION; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; POSTNATAL DEVELOPMENT; TIBIA; TRABECULAR BONE; UPREGULATION; VITAMIN D METABOLISM;

ANIMALS; BASE SEQUENCE; BONE DENSITY; CALCITRIOL; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION; INTESTINAL ABSORPTION; KIDNEY; MALE; MICE; MICE, INBRED C57BL; OSTEOBLASTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRACHLORODIBENZODIOXIN; UP-REGULATION;

ANIMALIA; MUS;

EID: 63649108605     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.01.025     Document Type: Article

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