Visualization of neuromelanin in the substantia nigra and locus ceruleus at 1.5T using a 3D-gradient echo sequence with magnetization transfer contrast

Magnetic Resonance in Medical Sciences

Volumn 7, Issue 4, 2008, Pages 205-210

  Nakane, Toshiki ^a   Nihashi, Takashi ^a   Kawai, Hisashi ^a   Naganawa, Shinji ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Locus ceruleus; Magnetization transfer contrast; Neuromelanin; Substantia nigra; Three dimensional gradient echo

Indexed keywords

MELANIN; NEUROMELANIN;

ADULT; ARTICLE; CHEMISTRY; COMPUTER ASSISTED DIAGNOSIS; FEMALE; HUMAN; LOCUS CERULEUS; MALE; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; SUBSTANTIA NIGRA;

ADULT; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LOCUS COERULEUS; MAGNETIC RESONANCE IMAGING; MALE; MELANINS; MIDDLE AGED; SUBSTANTIA NIGRA; YOUNG ADULT;

EID: 63649106965     PISSN: 13473182     EISSN: 18802206     Source Type: Journal    
DOI: 10.2463/mrms.7.205     Document Type: Article

References (15)

1. Sasaki M, Shibata E, Tohyama K, et al. Neuromelanin magnetic imaging of locus ceruleus and substantia nigra in Parkinson's disease. Neuroreport 2006; 17:1215-1218.
2. Wansapura JP, Holland SK, Dunn RS, Ball WS Jr. NMR relaxation times in the human brain at 3.0 tesla. J Magn Reson Imaging 1999; 9:531-538.
3. Melki PS, Mulkern RV. Magnetization transfer effects in multislice RARE sequences. Magn Reson Med 1992; 24:189-195.
4. Wolff S.D., Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989; 10:135-144.
5. Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med 1999; 42:952-962.
6. Miyazaki M, Kojima F, Ichinose N, Onozato Y, Igarashi H. A novel saturation transfer contrast method for 3D time-of-flight magnetic resonance angiography: a slice-selective off-resonance sinc pulse (SORS) technique. Magn Reson Med 1994; 32:52-59.
7. Bazelon M, Fenichel GM, Randall J. Studies on neuromelanin. I. A melanin system in the human adult brainstem. Neurology 1967; 17:512-519.
8. Graham DG. On the origin and significance of neuromelanin. Arch Pathol Lab Med 1979; 103:359-362.
9. Enochs WS, Nilges MJ, Swartz HM. Purified human neuromelanin, synthetic dopamine melanin as a potential model pigment, and the normal human substantia nigra: characterization by electron paramagnetic resonance spectroscopy. J Neurochem 1993; 61:68-79.
10. Enochs WS, Petherick P, Bogdanova A, Mohr U, Weissleder R. Paramagnetic metal scavenging by melanin: MR imaging. Radiology 1997; 204:417-423.
11. Edelman RR, Ahn SS, Chien D, et al. Improved time-of-flight MR angiography of the brain with magnetization transfer contrast. Radiology 1992; 184:395-399.
12. Naganawa S, Koshikawa T, Sato K, et al. Pseudostenosis of the internal carotid artery in 3D timeof-flight MR angiography: effects of a magnetization transfer contrast pulse and metallic material. Eur Radiol 2003; 13:2298-2303.
13. Grad J, Bryant RG. Nuclear magnetic cross-relaxation spectroscopy. J Magn Reson 1990; 90: l-8.
14. Tanttu JI, Sepponen RE, Lipton MJ, Kuusela T. Synergistic enhancement of MRI with Gd-DTPA and magnetization transfer. J Comput Assist Tomogr 1992; 16:19-24.
15. Shibata E, Sasaki M, Tohyama K, Otsuka K, Sakai A. Reduced signal of locus ceruleus in depression in quantitative neuromelanin magnetic resonance imaging. Neuroreport 2007; 18:415-418.