Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute Plasmodium falciparum malaria

Annals of Hematology

Volumn 88, Issue 5, 2009, Pages 411-415

  Ballal, Adil ^a   Saeed, Amal ^a   Rouina, Patricia ^b   Jelkmann, Wolfgang ^b  

^a UNIVERSITY OF KHARTOUM   (Sudan)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Anemia; Cytokines; Erythropoietin; Inflammation; Malaria; Plasmodium falciparum

Indexed keywords

CHLOROQUINE; CYTOKINE; ERYTHROPOIETIN; GAMMA INTERFERON; HEMOGLOBIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; IMMUNOLOGIC FACTOR; INTERLEUKIN 1;

ADOLESCENT; ADULT; ANEMIA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD PARASITE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HEMOGLOBIN BLOOD LEVEL; HUMAN; LEUKOCYTOSIS; MALARIA FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS INHIBITION; SUDAN; BLOOD; CASE CONTROL STUDY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT;

ADULT; CASE-CONTROL STUDIES; CHLOROQUINE; CYTOKINES; ERYTHROPOIETIN; HUMANS; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-1; INTERLEUKIN-6; MALARIA, FALCIPARUM; MALE; SUDAN;

EID: 63649095200     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-008-0636-z     Document Type: Article

References (22)

1. Brown AE, Webster HK, Teja IP, Keeratithakul D (1990) Macrophage activation in falciparum malaria as measured by neopterin and interferon-gamma. Clin Exp Immunol 82:97-101
2. Burchard GD, Radloff P, Philipps J, Nkeyi M, Knobloch J, Kremsner PG (1995) Increased erythropoietin production in children with severe malarial anemia. Am J Trop Med Hyg 53:547-551
3. Burgmann H, Looareesuwan S, Kapiotis S, Viravan C, Vanijanonta S, Hollenstein U et al (1996) Serum levels of erythropoietin in acute Plasmodium falciparum malaria. Am J Trop Med Hyg 54:280-283
4. Chang KH, Stevenson MM (2004) Effect of anemia and renal cytokine production on erythropoietin production during blood-stage malaria. Kidney Int 65:1640-1646. doi: 10.1111/j.1523-1755.2004.00573.x
5. Elamin SB, Malik EM, Abdelgadir T, Khamiss AH, Mohammed MM, Ahmed ES et al (2005) Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan. Malar J 4:41. doi: 10.1186/1475-2875-4-41
6. el-Hassan AM, Saeed AM, Fandrey J, Jelkmann W (1997) Decreased erythropoietin response in Plasmodium falciparum malaria-associated anaemia. Eur J Haematol 59:299-304
7. Fievet N, Moussa M, Tami G, Maubert B, Cot M, Deloron P et al (2001) Plasmodium falciparum induces a Th1/Th2 disequilibrium, favoring the Th1-type pathway, in the human placenta. J Infect Dis 183:1530-1534. doi: 10.1086/320201
8. Frisk-Holmberg M, Bergkvist Y, Domeij-Nyberg B, Hellstrom L, Jansson F (1979) Chloroquine serum concentration and side effects: Evidence for dose-dependent kinetics. Clin Pharmacol Ther 25:345-350
9. Hemmer CJ, Kern P, Holst FG, Radtke KP, Egbring R, Bierhaus A et al (1991) Activation of the host response in human Plasmodium falciparum malaria: Relation of parasitemia to tumor necrosis factor/cachectin, thrombin-antithrombin III, and protein C levels. Am J Med 91:37-44. doi: 10.1016/0002-9343(91)90071-5
10. Jelkmann W (1998) Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res 18:555-559
11. Kurtzhals JA, Rodrigues O, Addae M, Commey JO, Nkrumah FK, Hviid L (1997) Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malaria. Br J Haematol 97:169-174. doi: 10.1046/ j.1365-2141.1997.82654.x
12. Lamikanra AA, Brown DM, Potocnik A, Casals-Pascual C, Langhorne J, Roberts DJ (2007) Malarial anemia: Of mice and man. Blood 110:18-28. doi: 10.1182/blood-2006-09-018069
13. Malik EM, Mohamed TA, Elmardi KA, Mowien RM, Elhassan AH, Elamin SB et al (2006) From chloroquine to artemisinin-based combination therapy: The Sudanese experience. Malar J 5:65. doi: 10.1186/1475-2875-5-65
14. McDevitt MA, Xie J, Gordeuk V, Bucala R (2004) The anemia of malaria infection: Role of inflammatory cytokines. Curr Hematol Rep 3:97-106
15. Means RT, Krantz SB (1992) Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 80:1639-1647
16. Nussenblatt V, Mukasa G, Metzger A, Ndeezi G, Garrett E, Semba RD (2001) Anemia and interleukin-10, tumor necrosis factor alpha, and erythropoietin levels among children with acute, uncomplicated plasmodium falciparum malaria. Clin Diagn Lab Immunol 8:1164-1170. doi: 10.1128/CDLI.8.6.1164-1170.2001
17. Tagelsir N, Ibrahim Z, Medani A, Salih O, Hamad A, Giha H et al (2006) High frequency of Plasmodium falciparum PfCRT K76T and PfpghN86Y in patients clearing infection after chloroquine treatment in the Sudan. Acta Trop 97:19-25. doi: 10.1016/j.actatropica.2005.07.030
18. Verhoef H, West CE, Kraaijenhagen R, Nzyuko SM, King R, Mbandi MM et al (2002) Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children. Blood 100:3489-3494. doi: 10.1182/ blood-2001-12-0228
19. Weatherall DJ, Abdalla S (1982) The anaemia of Plasmodium falciparum malaria. Br Med Bull 38:147-151
20. Weiss G, Goodnough LT (2005) Anemia of chronic disease. N Engl J Med 352:1011-1023. doi: 10.1056/NEJMra041809
21. Wenisch C, Parschalk B, Narzt E, Looareesuwan S, Graninger W (1995) Elevated serum levels of IL-10 and IFN-gamma in patients with acute Plasmodium falciparum malaria. Clin Immunol Immunopathol 74:115-117. doi: 10.1006/clin.1995.1017
22. Word Health Organisation (1968) Nutritional anaemias. Report of a WHO scientific group.405:5-37