Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells

Toxicology and Applied Pharmacology

Volumn 236, Issue 3, 2009, Pages 261-269

  Anwar Mohamed, Anwar ^a   El Kadi, Ayman O S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Heavy metals; NAD(P)H:quinone oxidoreductase 1; TCDD; Vanadium

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CARCINOGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ISOTHIOCYANATE SULFORAPHANE; ISOTHIOCYANIC ACID DERIVATIVE; MESSENGER RNA; MUTAGENIC AGENT; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE:QUINONE OXIDOREDUCTASE 1; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VANADIUM;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME MECHANISM; GENE; GENE INDUCTION; GENETIC TRANSCRIPTION; HALF LIFE TIME; MOUSE; NONHUMAN; NQO1 GENE; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM;

ANTICARCINOGENIC AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOGENS; CELL LINE; DNA PRIMERS; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; ISOTHIOCYANATES; NAD(P)H DEHYDROGENASE (QUINONE); POLYMERASE CHAIN REACTION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; VANADIUM;

EID: 63649090032     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.002     Document Type: Article

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