Psychosis in children with velocardiofacial syndrome (22q11.2 deletion syndrome)

Current Psychiatry Reports

Volumn 11, Issue 2, 2009, Pages 99-105

  Jolin, Edith M ^a   Weller, Ronald A ^a   Weller, Elizabeth B ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENTION DEFICIT DISORDER; AUTISM; BIPOLAR DISORDER; CHROMOSOME 22Q; CHROMOSOME DELETION; COGNITIVE DEFECT; DIFFERENTIAL DIAGNOSIS; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; HALLUCINATION; HUMAN; MAJOR DEPRESSION; ONSET AGE; PSYCHOSIS; REVIEW; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; VELOCARDIOFACIAL SYNDROME;

CHILD; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 22; DIGEORGE SYNDROME; HUMANS; PSYCHOTIC DISORDERS;

EID: 63549145543     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-009-0016-y     Document Type: Review

References (53)

1. Shprintzen RJ, Higgins AM, Antshel K, et al.: Velo-cardiofacial syndrome. Curr Opin Pediatr 2005, 17:725-730.
2. Driscoll DA, Salvin J, Sellinger B, et al.: Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: Implications for genetic counseling and prenatal diagnosis. J Med Genet 1993, 30:813-817.
3. Lindsay EA: ChromosomaD microdeletions: dissecting del22q11 syndrome. Nat Rev Genet 2001, 2:858-868.
4. Emanuel BS, McDonald-McGinn D, Saitta SC, et al.: The 22q11.2 deletion syndrome. Adv Pediatr 2001, 48:39-73.
5. Scambler PJ: The 22q11 deletion syndromes. Hum Mol Genet 2000, 9:2421-2426.
6. Gothelf D: Velocardiofacial syndrome. Child Adolesc Psychiatr Clin N Am 2007, 16:677-693.
7. Botto LD, May K, Fernhoff PM, et al.: A population-based study of the 22q11.2 deletion: Phenotype, incidence, and contribution to major birth defects in the population. Pediatrics 2003, 112:101-107.
8. McDonald-McGinn DM, Kirschner R, Goldmuntz E, et al.: The Philadelphia story: Report on 250 patients. Genet Couns 1999, 10:11-24.
9. Shprintzen RJ, Goldberg RB, Lewin ML, et al.: A new syndrome involving cleft palate, cardiac anomalies, typical facies, and learning disabilities: Velo-cardio-facial syndrome. Cleft Palate J 1978, 5:56-62.
10. Shprintzen RJ, Goldberg R, Goldig-Kushner KJ, et al.: Lateonset psychosis in the velo-cardio-facial syndrome. Am J Med Genet 1992, 42:141-142.
11. Pulver AE, Nestadt G, Goldberg R, et al.: Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 1994, 182:476-478.
12. Bassett AS, Chow EWA 22q11 deletion syndrome: a genetic subtype of schizophrenia. Biol Psychiatry 1999, 46:882-891.
13. Murphy KC, Jones LA, Owen MJ: High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 1999, 56:940-945.
14. Bassett AS, Chow EW, Husted J, et al.: Clinical features of 78 adults with 22q11 deletion syndrome. Am J Med Genet A 2005, 138:307-313.
15. Arnold PD, Siegel-Bartelt J, Cytrynbaum C, et al.: Velo-cardio-facial syndrome: Implications of microdeletion 22q11 for schizophrenia and mood disorders. Am J Med Genet 2001, 105:354-362.
16. Feinstein C, Eliez S, Blasey C, et al.: Psychiatric disorders and behavioral problems in children with velocardiofacial syndrome: usefulness as phenotypic indicators of schizophrenia risk. Biol Psychiatry 2002, 51:312-318.
17. Antshel KM, Fremont W, Roizen NJ, et al.: ADHD, major depressive disorder, and simple phobias are prevalent psychiatric conditions in youth with velocardiofacial syndrome. J Am Acad Child Adolesc Psychiatry 2006, 45:596-603.
18. Gothelf D, Feinstein C, Thompson T, et al.: Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome. Am J Psychiatry 2007, 164:663-669.
19. Baker KD, Skuse DH: Adolescents and young adults with 22q11 deletion syndrome: Psychopathology in an at-risk group. Br J Psychiatry 2005, 186:115-120.
20. Debbane M, Glaser B, David MK, et al.: Psychotic symptoms in children and adolescents with 22q11.2 deletion syndrome: Neuropsychological and behavioral implications. Schizophr Res 2006, 84:187-193.
21. Tolbert HA: Psychoses in childrenAand adolescents: a review. J Clin Psychiatry 1996, 57(Suppl 3):4-8.
22. Masi G, Mucci M, CinziaCP: Children with schizophrenia: clinical picture and pharmacological treatment. CNS Drugs 2006, 10:841-866.
23. Schreier HA: Hallucinations in nonpMychotic children: more common than we think? J Am Acad Child Adolesc Psychiatry 1999, 38:623-625.
24. McGee R, Williams S, Poulton R: Hallucinations in nonpsychotic children. J Am Acad Child Adolesc Psychiatry 2000, 39:12-13.
25. Garralda ME: Characteristics of the psychoses of late onset in children and adolescents (a comparative study of hallucinating children). J Adolesc 1985, 8:195-207.
26. Zinkstok J, Amelsvort TV: Neuropsychological profile and neuroimaging in patients with 22q11.2 deletion syndrome. Child Neuropsychol 2005, 11:27-35.
27. Antshel KM, Kates WR, Roizen N, et al.: 22q11.2 deletion syndrome: genetics, neuroanatomy and cognitive/behavioral features. Child Neuropsychol 2005, 11:5-19.
28. Shprintzen RJ: Velo-carAio-facial syndrome: a distinctive behavioral phenotype. Ment Retard Dev Disabil Res Rev 2000, 6:142-147.
29. Bassett AS, Chow EW: Schizophrenia and 22q11.2 deletion syndrome. Curr Psychiatry Rep 2008, 10:148-157.
30. Sporn A, Addington A, Reiss AL, et al.: 22q11 deletion syndrome in childhood onset schizophrenia: An update. Mol Psychiatry 2004, 9:225-226.
31. Nicolson R, Lenane M, Singaracharlu S, et al.: Premorbid speech and language impairments in childhood-onset schizophrenia: Association with risk factors. Am J Psychiatry 2000, 157:794-800.
32. Bassett AS, Chow EW, AbdelMalik P, et al.: The schizophrenia phenotype in 22q11 deletion syndrome. Am J Psychiatry 2003, 160:1580-1586.
33. Schaer M, EliezUS: From genes to brain: understanding brain development in neurogenetic disorders using neuroimaging techniques. Child Adolesc Psychiatric Clin N Am 2007, 16:557-579.
34. Gogtay N: Cortical brain development inIschizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia. Schizophr Bull 2008, 34:30-36.
35. Caetano SC, Olvera RL, Glahn D, et al.: Fronto-limbic brain abnormalities in juvenile onset bipolar disorder. Biol Psychiatry 2005, 58:525-531.
36. Gothelf D, Pennimen L, Gu E, et al.: Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome. Schizophr Res 2007, 96:72-81.
37. Ulloa RE, Birmaher B, Axelson D, et al.: Psychosis in a pediatric mood and anxiety disorders clinic: Phenomenology and correlates. J Am Acad Child Adolesc Psychiatry 2000, 39:337-345.
38. Calderoni D, Wudarksy M, Bhangoo R, et al.: Differentiating childhood-onset schizophrenia from psychotic mood disorders. J Am Acad Child Adolesc Psychiatry 2001, 40:1190-1196.
39. Papolos DF, Faedda GL, Veit S, et al.: Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: Does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry 1996, 153:1541-1547.
40. Aneja A, Fremont WP, Antshel KM, et al.: Manic symptoms and behavioral dysregulation in youth with velocardiofacial syndrome (22q11.2 deletion syndrome). J Child Adolesc Psychopharmacol 2007, 17:105-114.
41. Henin A, Biederman J, Mick E, et al.: Childhood antecedent disorders to bipolar disorder in adults: A controlled study. J Affect Disord 2007, 99:51-57.
42. Perlis RH, Sachiko M, Marangell LB, et al.: Long-term implications of early onset in bipolar disorder: Data from the first 1000 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Biol Psychiatry 2004, 55:875-881.
43. Heinrichs RW, Zakzanis KK: NeurocogAitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998, 12:426-445.
44. Pavuluri MN, Schenkel LS, Aryal EM, et al.: Neurocognitive function in unmedicated and medicated euthymic pediatric bipolar patients. Am J Psychiatry 2006, 16:286-293.
45. Lewandowski KE, Shaski V, Berry P, et al.: Schizophreniclike neurocognitive deficits in children and adolescents with 22q11 deletion syndrome. Am J Med Gen B 2007, 144B:27-36.
46. Sobin C, Kiley-Brabeck K, Karayiorgou M: Lower prepulse inhibition in children with the 22q11 deletion syndrome. Am J Psychiatry 2005, 162:1090-1099.
47. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, edn 4. Washington, DC: American Psychiatric Association; 1994.
48. Volkmar FR: Childhood and adolAscent psychosis: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 1996, 35:843-851.
49. Niklasson L, Rasmussen P, Oskarsdottir S, et al.: Chromosome 22q11 deletion syndrome: Neuropsychiatric and neuropsychological aspects. Dev Med Child Neurol 2002, 44:44-50.
50. Fine SE, Weissman A, Gerdes M, et al.: Autism spectrum disorders and symptoms in children with molecularly confirmed 22q11.2 deletion syndrome. J Autism Dev Disord 2005, 35:461-470.
51. Lord C, Rutter M, LeCouteur A: Autism Diagnostic Interview-Revised. A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994, 24:659-685.
52. Antshel KM, Aneja A, Strunge L, et al.: Autism spectrum disorders in velo-cardio-facial syndrome (22q11.2 deletion). J Autism Dev Disord 2007, 37:1776-1786.
53. Vorstman JA, Morcus ME, Duijff SN, et al.: The 22q11.2 deletion in children: High rate of autistic disorders and early onset psychotic symptoms. J Am Acad Child Adolesc Psychiatry 2006, 45:1104-1113.