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Volumn 15, Issue 6, 2009, Pages 1998-2009

Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; LUCIFERASE; OSTEOPROTEGERIN; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; THYMIDINE KINASE; ZOLEDRONIC ACID;

EID: 63549135868     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-2444     Document Type: Article
Times cited : (33)

References (46)
  • 1
  • 2
    • 42449114035 scopus 로고    scopus 로고
    • Multiple myeloma
    • Kyle RA, Rajkumar SV. Multiple myeloma. Blood 2008;111:2962-72.
    • (2008) Blood , vol.111 , pp. 2962-2972
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 3
    • 20144388592 scopus 로고    scopus 로고
    • Elevated serum levels of stromal-derived factor-1 α are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    • Zannettino AC, Farrugia AN, Kortesidis A, et al. Elevated serum levels of stromal-derived factor-1 α are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res 2005;65:1700-9.
    • (2005) Cancer Res , vol.65 , pp. 1700-1709
    • Zannettino, A.C.1    Farrugia, A.N.2    Kortesidis, A.3
  • 4
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-κB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia AN, Atkins GJ, To LB, et al. Receptor activator of nuclear factor-κB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 2003;63:5438-45.
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3
  • 6
    • 17744396145 scopus 로고    scopus 로고
    • Death to the bad guys: Targeting cancer via Apo2L/TRAIL
    • Bouralexis S, Findlay DM, Evdokiou A. Death to the bad guys: targeting cancer via Apo2L/TRAIL. Apoptosis 2005;10:35-51.
    • (2005) Apoptosis , vol.10 , pp. 35-51
    • Bouralexis, S.1    Findlay, D.M.2    Evdokiou, A.3
  • 7
    • 0036598992 scopus 로고    scopus 로고
    • Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    • Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer 2002;2:420-30.
    • (2002) Nat Rev Cancer , vol.2 , pp. 420-430
    • Ashkenazi, A.1
  • 8
    • 35748946639 scopus 로고    scopus 로고
    • Investigating the interaction between osteoprotegerin and receptor activator of NF-κB or tumor necrosis factorrelated apoptosis-inducing ligand: Evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways
    • Vitovski S, Phillips JS, Sayers J, Croucher PI. Investigating the interaction between osteoprotegerin and receptor activator of NF-κB or tumor necrosis factorrelated apoptosis-inducing ligand: evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways. J Biol Chem 2007;282:31601-9.
    • (2007) J Biol Chem , vol.282 , pp. 31601-31609
    • Vitovski, S.1    Phillips, J.S.2    Sayers, J.3    Croucher, P.I.4
  • 9
    • 0034725664 scopus 로고    scopus 로고
    • Temperature sensitive differential affinity ofTRAIL for its receptors: DR5 is the highest affinity receptor
    • Truneh A, Sharma S, Silverman C, et al. Temperature sensitive differential affinity ofTRAIL for its receptors: DR5 is the highest affinity receptor. J Biol Chem 2000;275:23319-25.
    • (2000) J Biol Chem , vol.275 , pp. 23319-23325
    • Truneh, A.1    Sharma, S.2    Silverman, C.3
  • 10
    • 0037374460 scopus 로고    scopus 로고
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
    • Shipman CM, Croucher PI. Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res 2003;63:912-6.
    • (2003) Cancer Res , vol.63 , pp. 912-916
    • Shipman, C.M.1    Croucher, P.I.2
  • 11
    • 7344233085 scopus 로고    scopus 로고
    • Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
    • Emery JG, McDonnell P, Burke MB, et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 1998;273:14363-7.
    • (1998) J Biol Chem , vol.273 , pp. 14363-14367
    • Emery, J.G.1    McDonnell, P.2    Burke, M.B.3
  • 12
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosisinducing ligand in vivo
    • Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosisinducing ligand in vivo. Nat Med 1999;5:157-63.
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3
  • 13
    • 0032713075 scopus 로고    scopus 로고
    • Safety and antitumor activity of recombinant soluble Apo2 ligand
    • Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104:155-62.
    • (1999) J Clin Invest , vol.104 , pp. 155-162
    • Ashkenazi, A.1    Pai, R.C.2    Fong, S.3
  • 14
    • 0036794875 scopus 로고    scopus 로고
    • Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis
    • Atkins GJ, Bouralexis S, Evdokiou A, et al. Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis. Bone 2002;31:448-56.
    • (2002) Bone , vol.31 , pp. 448-456
    • Atkins, G.J.1    Bouralexis, S.2    Evdokiou, A.3
  • 15
    • 33745895281 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, overcomes resistance of human breast cancer cells to Apo2L/TRAIL
    • Butler LM,Liapis V,BouralexisS,et al. The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, overcomes resistance of human breast cancer cells to Apo2L/TRAIL. Int J Cancer 2006; 119:944-54.
    • (2006) Int J Cancer , vol.119 , pp. 944-954
    • Butler, L.M.1    Liapis, V.2    Bouralexis, S.3
  • 16
    • 0032530612 scopus 로고    scopus 로고
    • Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
    • GriffithTS, ChinWA, Jackson GC, Lynch DH, Kubin MZ. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J Immunol 1998;161: 2833-40.
    • (1998) J Immunol , vol.161 , pp. 2833-2840
    • Griffith, T.S.1    Chin, W.A.2    Jackson, G.C.3    Lynch, D.H.4    Kubin, M.Z.5
  • 17
    • 0030869432 scopus 로고    scopus 로고
    • Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
    • Degli-Esposti MA, Smolak PJ, Walczak H, et al. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J Exp Med 1997;186:1165-70.
    • (1997) J Exp Med , vol.186 , pp. 1165-1170
    • Degli-Esposti, M.A.1    Smolak, P.J.2    Walczak, H.3
  • 19
    • 0000005230 scopus 로고    scopus 로고
    • Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells
    • Zhang XD, FrancoAV, Nguyen T, Gray CP, Hersey P. Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells. J Immunol 2000;164:3961-70.
    • (2000) J Immunol , vol.164 , pp. 3961-3970
    • Zhang, X.D.1    Franco, A.V.2    Nguyen, T.3    Gray, C.P.4    Hersey, P.5
  • 20
    • 0011444717 scopus 로고    scopus 로고
    • Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types
    • Zhang XD, Nguyen T,Thomas WD, Sanders JE, Hersey P. Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types. FEBS Lett 2000;482:193-9.
    • (2000) FEBS Lett , vol.482 , pp. 193-199
    • Zhang, X.D.1    Nguyen, T.2    Thomas, W.D.3    Sanders, J.E.4    Hersey, P.5
  • 21
    • 0035912060 scopus 로고    scopus 로고
    • Intracellular mechanisms ofTRAIL: Apoptosis through mitochondrial-dependent and-independent pathways
    • Suliman A, Lam A, Datta R, Srivastava RK. Intracellular mechanisms ofTRAIL: apoptosis through mitochondrial-dependent and-independent pathways. Oncogene 2001;20:2122-33.
    • (2001) Oncogene , vol.20 , pp. 2122-2133
    • Suliman, A.1    Lam, A.2    Datta, R.3    Srivastava, R.K.4
  • 22
    • 0034812659 scopus 로고    scopus 로고
    • Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis inducing ligand in humans:characterization of in vivo efficacy, pharmacokinetics, and safety
    • Kelley SK, Harris LA, Xie D, et al. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis inducing ligand in humans:characterization of in vivo efficacy, pharmacokinetics, and safety. J Pharmacol ExpTher 2001;299:31-8.
    • (2001) J Pharmacol ExpTher , vol.299 , pp. 31-38
    • Kelley, S.K.1    Harris, L.A.2    Xie, D.3
  • 23
    • 3142735020 scopus 로고    scopus 로고
    • Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand cooperates with chemotherapy to inhibit orthotopic lung tumor growth and improve survival
    • Jin H, Yang R, Fong S, et al. Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand cooperates with chemotherapy to inhibit orthotopic lung tumor growth and improve survival. Cancer Res 2004;64:4900-5.
    • (2004) Cancer Res , vol.64 , pp. 4900-4905
    • Jin, H.1    Yang, R.2    Fong, S.3
  • 24
    • 0033584823 scopus 로고    scopus 로고
    • Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity
    • Roth W, Isenmann S, Naumann U, et al. Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity. Biochem Biophys Res Commun 1999;265:479-83.
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 479-483
    • Roth, W.1    Isenmann, S.2    Naumann, U.3
  • 25
    • 0034652156 scopus 로고    scopus 로고
    • Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy
    • Chinnaiyan AM, Prasad U, Shankar S, et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A 2000;97: 1754-9.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1754-1759
    • Chinnaiyan, A.M.1    Prasad, U.2    Shankar, S.3
  • 26
    • 0033572413 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11
    • Gliniak B, Le T. Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11. Cancer Res 1999;59:6153-8.
    • (1999) Cancer Res , vol.59 , pp. 6153-6158
    • Gliniak, B.1    Le, T.2
  • 27
    • 52649109485 scopus 로고    scopus 로고
    • Application of pharmacodynamic assays in a phase 1a trial of Apo2L/TRAIL in patients with advanced tumours [abstract 3535]
    • Pan Y. Application of pharmacodynamic assays in a phase 1a trial of Apo2L/TRAIL in patients with advanced tumours [abstract 3535]. J Clin Oncol (ASCO) 2007;25:3535.
    • (2007) J Clin Oncol (ASCO) , vol.25 , pp. 3535
    • Pan, Y.1
  • 28
    • 37149035841 scopus 로고    scopus 로고
    • A phase 1B safety and pharmacokinetic (PK) study of recombinant human Apo2L/TRAIL in combination with rituximab in patients with low-grade non-Hodgkin lymphoma [abstr 8078]
    • Yee L. A phase 1B safety and pharmacokinetic (PK) study of recombinant human Apo2L/TRAIL in combination with rituximab in patients with low-grade non-Hodgkin lymphoma [abstr 8078]. J Clin Oncol (ASCO) 2007;25:8078.
    • (2007) J Clin Oncol (ASCO) , vol.25 , pp. 8078
    • Yee, L.1
  • 29
    • 0035437171 scopus 로고    scopus 로고
    • TRAIL/ Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
    • Mitsiades CS, Treon SP, Mitsiades N, et al. TRAIL/ Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood 2001;98:795-804.
    • (2001) Blood , vol.98 , pp. 795-804
    • Mitsiades, C.S.1    Treon, S.P.2    Mitsiades, N.3
  • 30
    • 2442562277 scopus 로고    scopus 로고
    • A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
    • PonomarevV, Doubrovin M, Serganova I, etal. A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur J Nucl Med Mol Imaging 2004;31:740-51.
    • (2004) Eur J Nucl Med Mol Imaging , vol.31 , pp. 740-751
    • Ponomarev, V.1    Doubrovin, M.2    Serganova, I.3
  • 31
    • 0030060389 scopus 로고    scopus 로고
    • A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning
    • Zannettino AC, Rayner JR, Ashman LK, Gonda TJ, Simmons PJ. A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning. J Immunol 1996;156:611-20.
    • (1996) J Immunol , vol.156 , pp. 611-620
    • Zannettino, A.C.1    Rayner, J.R.2    Ashman, L.K.3    Gonda, T.J.4    Simmons, P.J.5
  • 32
    • 0027449196 scopus 로고
    • Development of a novel spontaneous metastasis model of human osteosarcoma transplanted or thotopically into bone of athymic mice
    • Berlin O, Samid D, Donthineni-Rao R, Akeson W, Amiel D, Woods VL. Development of a novel spontaneous metastasis model of human osteosarcoma transplanted or thotopically into bone of athymic mice. Cancer Res 1993;53:4890-5.
    • (1993) Cancer Res , vol.53 , pp. 4890-4895
    • Berlin, O.1    Samid, D.2    Donthineni-Rao, R.3    Akeson, W.4    Amiel, D.5    Woods, V.L.6
  • 33
    • 33744934513 scopus 로고    scopus 로고
    • Apo2L/tumor necrosis factor-related apoptosis-inducing ligand prevents breast cancer-induced bone destruction in a mouse model
    • Thai le M, Labrinidis A, Hay S, et al. Apo2L/tumor necrosis factor-related apoptosis-inducing ligand prevents breast cancer-induced bone destruction in a mouse model. Cancer Res 2006;66:5363-70.
    • (2006) Cancer Res , vol.66 , pp. 5363-5370
    • Thai le, M.1    Labrinidis, A.2    Hay, S.3
  • 35
    • 0033756507 scopus 로고    scopus 로고
    • Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5
    • Sims NA, Clement-Lacroix P, Da Ponte F, et al. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest 2000;106:1095-103.
    • (2000) J Clin Invest , vol.106 , pp. 1095-1103
    • Sims, N.A.1    Clement-Lacroix, P.2    Da Ponte, F.3
  • 36
    • 36849034968 scopus 로고    scopus 로고
    • TRAIL inhibits osteoclastic differentiation by counteracting RANKL dependent p27Kip1 accumulation in pre-osteoclast precursors
    • Zauli G, Rimondi E, Stea S, et al. TRAIL inhibits osteoclastic differentiation by counteracting RANKL dependent p27Kip1 accumulation in pre-osteoclast precursors. J Cell Physiol 2008;214:117-25.
    • (2008) J Cell Physiol , vol.214 , pp. 117-125
    • Zauli, G.1    Rimondi, E.2    Stea, S.3
  • 37
    • 4644323767 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF
    • Zauli G, Rimondi E,Nicolin V, Melloni E,Celeghini C, Secchiero P. TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF. Blood 2004;104:2044-50.
    • (2004) Blood , vol.104 , pp. 2044-2050
    • Zauli, G.1    Rimondi, E.2    Nicolin, V.3    Melloni, E.4    Celeghini, C.5    Secchiero, P.6
  • 39
    • 45949102602 scopus 로고    scopus 로고
    • Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?
    • Labrinidis A, LiapisV,Thai le M, et al. Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis? Blood 2008;111:5411-2.
    • (2008) Blood , vol.111 , pp. 5411-5412
    • Labrinidis, A.1    LiapisV2    Thai le, M.3
  • 40
    • 0035050960 scopus 로고    scopus 로고
    • Differential hepatocyte toxicity of recombinant Apo2L/ TRAIL versions
    • Lawrence D, Shahrokh Z, Marsters S, et al. Differential hepatocyte toxicity of recombinant Apo2L/ TRAIL versions. Nat Med 2001;7:383-5.
    • (2001) Nat Med , vol.7 , pp. 383-385
    • Lawrence, D.1    Shahrokh, Z.2    Marsters, S.3
  • 41
    • 40949138762 scopus 로고    scopus 로고
    • Structural and functional analysis of the interaction between the agonistic and monoclonal antibody Apomab and the proapoptotic receptor DR5
    • Adams C, Totpal K, Lawrence D, et al. Structural and functional analysis of the interaction between the agonistic and monoclonal antibody Apomab and the proapoptotic receptor DR5. Cell Death Differ 2008; 15:751-6.
    • (2008) Cell Death Differ , vol.15 , pp. 751-756
    • Adams, C.1    Totpal, K.2    Lawrence, D.3
  • 43
    • 44749091927 scopus 로고    scopus 로고
    • A phase 1 safety and pharmacokinetic study of Apomab, a human DR5 agonistic antibody, in patients with advanced cancer [abstract]
    • Camidge D, Herbst RS, Gordon M, et al. A phase 1 safety and pharmacokinetic study of Apomab, a human DR5 agonistic antibody, in patients with advanced cancer [abstract]. Proc ASCO 2007;25: 3582.
    • (2007) Proc ASCO , vol.25 , pp. 3582
    • Camidge, D.1    Herbst, R.S.2    Gordon, M.3
  • 44
    • 33750621119 scopus 로고    scopus 로고
    • HGS-ETR1, a fully human monoclonal antibody to the tumor necrosis factor-related apoptosis-inducing ligand death receptor 1 (TRAIL-R1) in patients with advanced solid cancer: Results of a phase1trial [abstract]
    • Hotte SJ, HirteHW, Chen EX, etal. HGS-ETR1, a fully human monoclonal antibody to the tumor necrosis factor-related apoptosis-inducing ligand death receptor 1 (TRAIL-R1) in patients with advanced solid cancer: results of a phase1trial [abstract]. Proc ASCO 2005;23:3052.
    • (2005) Proc ASCO , vol.23 , pp. 3052
    • Hotte, S.J.1    Hirte, H.W.2    Chen, E.X.3
  • 45
    • 45749137688 scopus 로고    scopus 로고
    • A phase 1b study to assess the safety of lexatumumab, a human monoclonal antibody that activatesTRAIL-R2, in combination with gemcitabine, pemetrexed, doxorubicin or FOLFIRI [abstract]
    • Sikic BI,Wakelee HA, von Mehren M, et al. A phase 1b study to assess the safety of lexatumumab, a human monoclonal antibody that activatesTRAIL-R2, in combination with gemcitabine, pemetrexed, doxorubicin or FOLFIRI [abstract]. Proc ASCO 2007;25: 14006.
    • (2007) Proc ASCO , vol.25 , pp. 14006
    • Sikic, B.I.1    Wakelee, H.A.2    von Mehren, M.3
  • 46
    • 34248187996 scopus 로고    scopus 로고
    • Phase 1 pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonistic activity to tumour necrosis factorrelated apoptosis-inducing ligand receptor-1
    • Tolcher AW, Mita M, Meropol NJ, et al. Phase 1 pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonistic activity to tumour necrosis factorrelated apoptosis-inducing ligand receptor-1. J Clin Oncol 2007;25:1390-5.
    • (2007) J Clin Oncol , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3


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