Functional analysis of neurosteroidal oestrogen using gene-disrupted and transgenic mice

Journal of Neuroendocrinology

Volumn 21, Issue 4, 2009, Pages 365-369

  Harada, Nobuhiro ^a   Wakatsuki, T ^a   Aste, N ^a   Yoshimura, N ^a   Honda, S I ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aromatase; Brain specific promoter; DNA microarray; Knockout mouse; Transgenic mouse

Indexed keywords

ANDROGEN; AROMATASE; ESTROGEN; NEUROHORMONE;

AGGRESSION; AMYGDALOID NUCLEUS; ANDROGEN BLOOD LEVEL; ANXIETY; APOPTOSIS; CELL FUNCTION; CELL PROLIFERATION; COMPULSION; CONFERENCE PAPER; DNA MICROARRAY; DOPAMINERGIC NERVE CELL; ENERGY METABOLISM; ESTROGEN ACTIVITY; ESTROGEN BLOOD LEVEL; EXON; EXPLORATORY BEHAVIOR; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; INCREASED APPETITE; LIBIDO; MATE CHOICE; NEUROENDOCRINE SYSTEM; NONHUMAN; PARENTAL BEHAVIOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEX DIFFERENTIATION; SEXUAL BEHAVIOR; TRANSGENE; ZONA INCERTA;

ANIMALS; ANXIETY; AROMATASE; BRAIN; ESTROGENS; FEEDING BEHAVIOR; GENE EXPRESSION; HUMANS; MICE; MICE, TRANSGENIC; PATERNAL BEHAVIOR; PROMOTER REGIONS, GENETIC; SEXUAL BEHAVIOR, ANIMAL; SOCIAL BEHAVIOR;

EID: 63549108122     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2009.01857.x     Document Type: Conference Paper

References (47)

1. Balthazart J, Foidart A, Surlemont C, Harada N. Distribution of aromatase-immunoreactive cells in the mouse forebrain. Cell Tissue Res 1991; 263: 71-79.
2. Harada N, Yamada K. Ontogeny of aromatase messenger ribonucleic acid in mouse brain: Fluorometrical quantitation by polymerase chain reaction. Endocrinology 1992; 131: 2306-2312.
3. Honda S, Harada N, Takagi Y. The alternative exons 1 of the mouse aromatase cytochrome P-450 gene. Biochim Biophys Acta 1996; 1305: 145-150.
4. Honda S, Harada N, Takagi Y. Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain. Biochem Biophys Res Commun 1994; 198: 1153-1160.
5. Beach FA. A review of physiological and psychological studies of the sexual behavior in mammals. Physiol Rev 1946; 27: 240-306.
6. Pfaff D. Nature of sex hormone effects on rat sex behavior: Specificity of effects and individual patterns of response. J Comp Physiol Psychol 1970; 73: 349-358.
7. McDonald P, Beyer C, Newton F, Brien B, Baker R, Tan HS, Sampson C, Kitching P, Greenhill R, Pritchard D. Failure of 5alpha-dihydrotestosterone to initiate sexual behaviour in the castrated male rats. Nature 1970; 227: 964-965.
8. Beyer C, Morali G, Naftolin F, Larsson K, Perez-Palacios G. Effects of some antiestrogens and aromatase inhibitors on androgen induced sexual behavior in castrated male rats. Horm Behav 1976; 7: 353-363.
9. Christensen LW, Clements LG. Blockage of testosterone-induced mounting behavior in the male rat with intracranial application of the aromatase inhibitor androst-1,3,6-triene-3, 17-dione. Endocrinology 1975; 97: 1545-1551.
10. Naftolin F, Ryan KJ, Petro Z. Aromatization of androstenedione by the anterior hypothalamus of adult male and female rats. Endocrinology 1972; 90: 295-298.
11. MacLusky NJ, Naftolin F. Sexual differentiation of the central nervous system. Science 1981; 211: 1294-1303.
12. Ogawa S, Lubahn DB, Korach KS, Pfaff DW. Behavioral effects of estrogen receptor gene disruption in male mice. Proc Natl Acad Sci USA 1997; 94: 1476-1481.
13. Wersinger SR, Sannen K, Villalba C, Lubahn DB, Rissman EF, De Vries GJ. Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene. Horm Behav 1997; 32: 176-183.
14. Ogawa S, Chan J, Chester AE, Gustafsson JA, Korach KS, Pfaff DW. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice. Proc Natl Acad Sci USA 1999; 96: 12887-12892.
15. Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, Korach KS, Pfaff DW. Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). Proc Natl Acad Sci USA 2000; 97: 14737-14741.
16. Deladoey J, Fluck C, Bex M, Yoshimura N, Harada N, Mullis PE. Aromatase deficiency caused by a novel P450arom gene mutation: Impact of absent estrogen production on serum gonadotropin concentration in a boy. J Clin Endocrinol Metab 1999; 84: 4050-4054.
17. Ito Y, Fisher CR, Conte FA, Grumbach MM, Simpson ER. Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Proc Natl Acad Sci USA 1993; 90: 11673-11677.
18. Harada N, Ogawa H, Shozu M, Yamada K, Suhara K, Nishida E, Takagi Y. Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency. J Biol Chem 1992; 267: 4781-4785.
19. Carani C, Rochira V, Faustini-Fustini M, Balestrieri A, Granata AR. Role of oestrogen in male sexual behaviour: Insights from the natural model of aromatase deficiency. Clin Endocrinol (Oxf) 1999; 51: 517-524.
20. Carani C, Granata AR, Rochira V, Caffagni G, Aranda C, Antunez P, Maffei LE. Sex steroids and sexual desire in a man with a novel mutation of aromatase gene and hypogonadism. Psychoneuroendocrinology 2005; 30: 413-417.
21. Honda S, Harada N, Ito S, Takagi Y, Maeda S. Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophy Res Commun 1998; 252: 445-449.
22. Matsumoto T, Honda S, Harada N. Alteration in sex-specific behaviors in male mice lacking the aromatase gene. Neuroendocrinology 2003; 77: 416-424.
23. Matsumoto T, Honda S, Harada N. Neurological effects of aromatase deficiency in the mouse. J Steroid Biochem Mol Biol 2003; 86: 357-365.
24. Fisher CR, Graves KH, Parlow AF, Simpson ER. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 1998; 95: 6965-6970.
25. Toda K, Takeda K, Okada T, Akira S, Saibara T, Kaname T, Yamamura K, Onishi S, Shizuta Y. Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol. J Endocrinol 2001; 170: 99-111.
26. Svare B, Gandelman R. Aggressive behavior of juvenile mice: Influence of androgen and olfactory stimuli. Dev Psychobiol 1975; 8: 405-415.
27. Simon NG, Whalen RE, Tate MP. Induction of male-typical aggression by androgens but not by estrogens in adult female mice. Horm Behav 1985; 19: 204-212.
28. Sato T, Matsumoto T, Kawano H, Watanabe T, Uematsu Y, Sekine K, Fukuda T, Aihara K, Krust A, Yamada T, Nakamichi Y, Yamamoto Y, Nakamura T, Yoshimura K, Yoshizawa T, Metzger D, Chambon P, Kato S. Brain masculinization requires androgen receptor function. Proc Natl Acad Sci USA 2004; 101: 1673-1678.
29. Foidart A, Harada N, Balthazart J. Aromatase-immunoreactive cells are present in mouse brain areas that are known to express high levels of aromatase activity. Cell Tissue Res 1995; 280: 561-574.
30. Harada N, Honda S, Hirasawa G, Hatano O, Sasano H. Histological Lesions in Aromatase-deficient Mice. Tokyo: Universal Academy Press, Inc., 2000.
31. Aste N, Honda S, Harada N. Forebrain Fos responses to reproductively related chemosensory cue in aromatase knockout mice. Brain Res Bull 2003; 60: 191-200.
32. Bakker J, Honda S, Harada N, Balthazart J. Sexual partner preference requires a functional aromatase (cyp19) gene in male mice. Horm Behav 2002; 42: 158.
33. Toda K, Saibara T, Okada T, Onishi S, Shizuta Y. A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19). J Endocrinol 2001; 168: 217-220.
34. Toda K, Okada T, Takeda K, Akira S, Saibara T, Shiraishi M, Onishi S, Shizuta Y. Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17beta-oestradiol to aromatase gene (Cyp19) knockout mice. J Endocrinol 2001; 168: 455-463.
35. Hill RA, McInnes KJ, Gong EC, Jones ME, Simpson ER, Boon WC. Estrogen deficient male mice develop compulsive behavior. Biol Psychiatry 2007; 61: 359-366.
36. Bakker J, Honda S, Harada N, Balthazart J. Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice. Horm Behav 2004; 46: 1-10.
37. Dalla C, Antoniou K, Papadopoulou-Daifoti Z, Balthazart J, Bakker J. Oestrogen-deficient female aromatase knockout (ArKO) mice exhibit 'depressive-like'symptomatology. Eur J Neurosci 2004; 20: 217-228.
38. Bertrand PP, Paranavitane UT, Chavez C, Gogos A, Jones M, van den Buuse M. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: A behavioral and electrochemical study. Brain Res 2005; 1064: 10-20.
39. Harada N, Matsumoto T, Yoshimura N, Sakamoto H, Honda S. Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies. J Steroid Biochem Mol Biol 2001; 79: 151-156.
40. Honda S, Harada N, Abe-Dohmae S, Takagi Y. Identification of cis-acting elements in the proximal promoter region for brain-specific exon 1 of the mouse aromatase gene. Brain Res Mol Brain Res 1999; 66: 122-132.
41. Honda SI, Matsumoto T, Harada N. Characterization and purification of a protein binding to the cis-acting element for brain-specific exon 1 of the mouse aromatase gene. J Steroid Biochem Mol Biol 2001; 79: 255-260.
42. Abe Dohmae S, Tanaka R, Takagi Y, Harada N. In vitro increase of aromatase mRNA in diencephalic neurons. Neuroendocrinology 1996; 63: 46-52.
43. Jakab RL, Horvath TL, Leranth C, Harada N, Naftolin F. Aromatase immunoreactivity in the rat brain: Gonadectomy-sensitive hypothalamic neurons and an unresponsive 'limbic ring'of the lateral septum-bed nucleus-amygdala complex. J Steroid Biochem Mol Biol 1993; 44: 481-498.
44. Harada N, Honda S. Analysis of spatiotemporal regulation of aromatase in the brain using transgenic mice. J Steroid Biochem Mol Biol 2005; 95: 49-55.
45. Toda K, Takeda K, Akira S, Saibara T, Okada T, Onishi S, Shizuta Y. Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17[beta]-estradiol or a peroxisome proliferator. J Steroid Biochem Mol Biol 2001; 79: 11-17.
46. Jones ME, Thorburn AW, Britt KL, Hewitt KN, Wreford NG, Proietto J, Oz OK, Leury BJ, Robertson KM, Yao S, Simpson ER. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci USA 2000; 97: 12735-12740.
47. Hill RA, Chow J, Fritzemeier K, Simpson ER, Boon WC. Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively. Mol Cell Neurosci 2007; 36: 146-157.