Neuropeptide Y modulates the antidepressant activity of imipramine in olfactory bulbectomized rats: Involvement of NPY Y1 receptors

Brain Research

Volumn 1266, Issue , 2009, Pages 45-53

  Goyal, Sameer N ^a   Upadhya, Manoj A ^b   Kokare, Dadasaheb M ^b   Bhisikar, Snehal M ^b   Subhedar, Nishikant K ^c  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b RTM NAGPUR UNIVERSITY   (India)

^c INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

Author keywords

BIBP3226; Depression; Neuropeptide Y; Open field test; Tricyclic antidepressant

Indexed keywords

IMIPRAMINE; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; NEUROPEPTIDE Y[31 LEUCINE 34 PROLINE]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; HYPERACTIVITY; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ARGININE; BEHAVIOR, ANIMAL; DEPRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIPRAMINE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; NEUROPEPTIDE Y; OLFACTORY BULB; PSYCHOMOTOR AGITATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y;

RATTUS;

EID: 63449119252     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.02.033     Document Type: Article

References (83)

1. Baker R.A., Herkenham M., and Brady L.S. Effects of long-term treatment with antidepressant drugs on proopiomelanocortin and neuropeptide Y mRNA expression in the hypothalamic arcuate nucleus of rats. J. Neuroendocrinol. 8 (1996) 337-343
2. Blasquez C., Jegou S., Tranch Bunel D., Fournier A., and Vaudry H. Neuropeptide Y inhibits alpha-MSH release from rat hypothalamic slices through a pertussis toxin-sensitive G protein. Brain Res. 596 (1992) 163-168
3. Blasquez C., Jegou S., Friard O., Tonon M.C., Fournier A., and Vaudry H. Effect of centrally administered neuropeptide Y on hypothalamic and hypophyseal proopiomelanocortin-derived peptides in the rat. Neuroscience 68 (1995) 221-227
4. Blessing W.W., Howe P.R., Joh T.H., Oliver J.R., and Willoughby J.O. Distribution of tyrosine hydroxylase and neuropeptide Y-like immunoreactive neurons in rabbit medulla oblongata, with attention to colocalization studies, presumptive adrenaline-synthesizing perikarya, and vagal preganglionic cells. J. Comp. Neurol. 248 (1986) 285-300
5. Brown K.S., Gentry R.M., and Rowland N.E. Central injection in rats of alphamelanocyte-stimulating hormone analog: effects on food intake and brain Fos. Regul. Pept. 78 (1998) 89-94
6. Caberlotto L., Fuxe K., Overstreet D.H., Gerrard P., and Hurd Y.L. Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. Mol. Brain Res. 59 (1998) 58-65
7. Caberlotto L., Jimenez P., Overstreet D.H., Hurd Y.L., Mathe A.A., and Fuxe K. Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression. Neurosci. Lett. 265 (1999) 191-194
8. Cairncross K.D., Cox B., Forster C., and Wren A.F. The olfactory bulbectomized rat: a simple model for detecting drugs with antidepressant potential [proceedings]. Br. J. Pharmacol. 61 (1977) 497P
9. Cairncross K.D., Cox B., Kerwin R., Forster C., and Wren A.F. Behavioural changes induced by olfactory bulb ablation and intrabulbar injection of 5,6-DHT: susceptibility to psychotropic drugs [proceedings]. Br. J. Pharmacol. 62 (1978) 400P-401P
10. Cairncross K.D., Wren A., Forster C., Cox B., and Schnieden H. The effect of psychoactive drugs on plasma corticosterone levels and behavioural in the bulbectomised rat. Pharmacol. Biochem. Behav. 10 (1979) 355-359
11. Chaki S., Hirota S., Funakoshi T., Suzuki Y., Suetake S., Okubo T., Ishii T., Nakazato A., and Okuyama S. Anxiolytic like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-m ethoxynapthalen-1-yl) butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor. J. Pharmacol. Exp. Ther. 304 (2003) 818-826
12. Chaki S., Oshida Y., Ogawa S., Funakoshi T., Shimazaki T., Okubo T., Nakazato A., and Okuyama S. MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity. Pharmacol. Biochem. Behav. 82 (2005) 621-626
13. Chronwall B.M., DiMaggio D.A., Massari V.J., Pickel V.M., Ruggiero D.A., and O'Donohue T.L. The anatomy of neuropeptide Y containing neurons in the rat brain. Neuroscience 15 (1985) 1159-1181
14. Colmers W.F., and Bleakman D. Effect of neuropeptide Y on electrical properties of neurons. Trends Neurosci. 17 (1994) 373-379
15. Cuellar-Quintero J.L., Garcia D.E., and Cruzblanca H. The antidepressant imipramine inhibits the M-type K+ current in rat sympathetic neurons. NeuroReport 12 (2001) 2195-2198
16. Dandekar M.P., Singru P.S., Kokare D.M., and Subhedar N.K. Cocaine- and amphetamine-regulated transcript peptide plays a role in the manifestation of depression: social isolation and olfactory bulbectomy models reveal unifying principles. Neuropsychopharmacology (2008) 10.1038/npp.2008.201
17. Delbende C., Jegou S., Tranchand-Bunel D., Blasquez C., and Vaudry H. Gamma-aminobutyric acid inhibits the release of alpha-melanocyte-stimulating hormone from rat hypothalamic slices. Brain Res. 497 (1989) 86-93
18. de Quidt M.E., and Emson P.C. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system: I, Radioimmunoassay and chromatographic characterization. Neuroscience 18 (1986) 527-543
19. Doods H.N., Wieland H.A., Engel W., Eberlein W., Willim K.D., Entzeroth M., Wienen W., and Rudolf K. BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: a review of its pharmacological properties. Regul. Pept. 65 (1996) 71-77
20. Duman R.S., Strada S.J., and Enna S.J. Effect of imipramine and adrenocorticotropin administration on the rat brain norepinephrine-coupled cyclic nucleotide generating system: alterations in alpha and beta adrenergic components. J. Pharmacol. Exp. Ther. 234 (1985) 409-414
21. Dumont Y., Fournier A., and Quirion R. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J. Neurosci. 18 (1998) 5565-5574
22. Everitt B.J., Hokfelt T., Terenius L., Tatemoto K., Mutt V., and Goldstein M. Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 11 (1984) 443-462
23. Flood J.F., Hernandez E.N., and Morley J.E. Modulation of memory processing by neuropeptide Y. Brain Res. 421 (1987) 280-290
24. Garcia de Yebenes E., Li S., Fournier A., St-Pierre S., and Pelletier G. Regulation of proopiomelanocortin gene expression by neuropeptide Y in the rat arcuate nucleus. Brain Res. 674 (1995) 112-116
25. Giardina W.J., and Radek R.J. Effects of imipramine on the nocturnal behavior of bilateral olfactory bulbectomized rats. Biol. Psychiatry 29 (1991) 1200-1208
26. Gonzalez M.I., Kalia V., Hole D.R., and Wilson C.A. Alpha-melanocyte-stimulating hormone (alpha-MSH) and melanin-concentrating hormone (MCH) modify monoaminergic levels in the preoptic area of the rat. Peptides 18 (1997) 387-392
27. Goyal S.N., Kokare D.M., Chopde C.T., and Subhedar N.K. Alpha-melanocyte stimulating hormone antagonizes antidepressant-like effect of neuropeptide Y in Porsolt's test in rats. Pharmacol. Biochem. Behav. 85 (2006) 369-377
28. Gray J.A., and Lalljee B. Sex differences in emotional behaviour in the rat: correlation between open-field defecation and active avoidance. Anim. Behav. 22 (1974) 856-861
29. Hansen M.J., and Morris M.J. Evidence for an interaction between neuropeptide Y and the melanocortin-4 receptor on feeding in the rat. Neuropharmacology 42 (2002) 792-797
30. 34]neuropeptide Y potentiate potassium-induced noradrenaline release in the paraventricular nucleus of the aged rat. Brain Res. 750 (1997) 301-304
31. Haynes A.C., Arch J.R., Wilson S., McClue S., and Buckingham R.E. Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor. Regul. Pept. 75-76 (1998) 355-361
32. Heilig M., Wahlestedt C., Ekman R., and Widerlov E. Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain. Eur. J. Pharmacol. 147 (1988) 465-467
33. Heilig M., Soderpalm B., Engel J.A., and Widerlov E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology 98 (1989) 524-529
34. Heilig M., Vecsei L., Wahlestedt C., Alling C., and Widerlov E. Effects of centrally administered neuropeptide Y (NPY) and NPY13-36 on the brain monoaminergic systems of the rat. J. Neural Transm. Gen. Sect. 79 (1990) 193-208
35. Holmes P.V., Davis R.C., Masini C.V., and Primeaux S.D. Effect of olfactory bulbactomy on neuropeptide gene expression in the rat olfactory/limbic system. Neuroscience 86 (1998) 587-596
36. Howell O.W., Scharfman H.E., Herzog H., Sundstrom L.E., Beck-Sickinger A., and Gray W.P. Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J. Neurochem. 86 (2003) 646-659
37. Inui A., Okita M., Inoue T., Sakatani N., Morioka H., Shii K., Yokono K., Mizuno N., and Baba S. Characterization of peptide YY receptors in the brain. Endocrinology 124 (1989) 402-409
38. Ishida H., Shirayama Y., Iwata M., and Kawahara R. Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats. Brain Res. 1046 (2005) 239-243
39. Jaako-Movits K., Zharkovsky T., Pedersen M., and Zharkovsky A. Decreased hippocampal neurogenesis following olfactory bulbectomy is reversed by repeated citalopram administration. Cell. Mol. Neurobiol. 26 (2006) 1559-1570
40. Jain M.R., and Subhedar N.K. Increase in number of LHRH neurones in septal-preoptic area of rats following chronic amitriptyline treatment: implication in antidepressant effect. Brain Res. 604 (1993) 7-15
41. Jancsar S.M., and Leonard B.E. Changes in neurotransmitter metabolism following olfactory bulbectomy in the rat. Prog. Neuro-psychopharmacol. Biol. Psychiatry 8 (1984) 263-269
42. Jesberger J.A., and Richardson J.S. Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats. Behav. Neurosci. 100 (1986) 256-274
43. Karlsson R.M., Choe J.S., Cameron H.A., Thorsell A., Crawley J.N., Holmes A., and Heilig M. The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice. Psychopharmacology 195 (2008) 547-557
44. Kask A., Rago L., and Harro J. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br. J. Pharmacol. 124 (1998) 1507-1515
45. Kelly J.P., Wrynn A.S., and Leonard B.E. The olfactory bulbectomized rat as a model of depression: an update. Pharmacol. Ther. 74 (1997) 299-316
46. Kitamura Y., Araki H., Nagatani T., Takao K., Shibata K., and Gomita Y. Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Acta Med. Okayama 58 (2004) 271-274
47. Knuuttila J.E., Toronen P., and Castren E. Effects of antidepressant drug imipramine on gene expression in rat prefrontal cortex. Neurochem. Res. 29 (2004) 1235-1244
48. Kokare D.M., Chopde C.T., and Subhedar N.K. Participation of α-melanocyte stimulating hormone in ethanol-induced anxiolysis and withdrawal anxiety in rats. Neuropharmacology 51 (2006) 536-545
49. Kokare D.M., Singru P.S., Dandekar M.P., Chopde C.T., and Subhedar N.K. Involvement of alpha-melanocyte stimulating hormone (α-MSH) in differential ethanol exposure and withdrawal related depression in rat: neuroanatomical-behavioral correlates. Brain Res. 1216 (2008) 53-67
50. Marks H.E., Remley N.R., Seago J.D., and Hastings D.W. Effects of bilateral lesions of the olfactory bulbs of rats on measures of learning and motivation. Physiol. Behav. 7 (1971) 1-6
51. Martel J.C., St-Pierre S., Bedard P.J., and Quirion R. Comparison of [125I]Bolton-Hunter neuropeptide Y binding sites in the forebrain of various mammalian species. Brain Res. 419 (1987) 403-407
52. Martel J.C., Fournier A., St-Pierre S., Dumont Y., Forest M., and Quirion R. Comparative structural requirements of brain neuropeptide Y binding sites and vas deferens neuropeptide Y receptors. Mol. Pharmacol. 38 (1990) 494-502
53. Michel M.C., Beck-Sickinger A., Cox H., Doods H.N., Herzog H., Larhammar D., Quirion R., Schwartz T., and Westfall T. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50 (1998) 143-150
54. Overstreet D.H. The Flinders sensitive line rats: a genetic animal model of depression. Neurosci. Biobehav. Rev. 17 (1993) 51-68
55. Overstreet D.H., Pucilowski O., Rezvani A.H., and Janowsky D.S. Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders sensitive line rats as an animal model of depression. Psychopharmacology 121 (1995) 27-37
56. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1998), Academic Press, London
57. Rao T.L., Kokare D.M., Sarkar S., Khisti R.T., Chopde C.T., and Subhedar N. GABAergic agents prevent alpha-melanocyte stimulating hormone induced anxiety and anorexia in rats. Pharmacol. Biochem. Behav. 76 (2003) 417-423
58. Redmond A.M., Kelly J.P., and Leonard B.E. The determination of the optimal dose of milnacipran in the olfactory bulbectomized rat model of depression. Pharmacol. Biochem. Behav. 62 (1999) 619-623
59. Redrobe J.P., Dumout Y., St-Pierre J.A., and Quirion R. Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition. Brain Res. 848 (1999) 153-166
60. Redrobe J.P., Dumont Y., Fournier A., and Quirion R. The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 26 (2002) 615-624
61. Redrobe J.P., Dumont Y., Fournier A., Baker G.B., and Quirion R. Role of serotonin (5-HT) in the antidepressant-like properties of neuropeptide Y (NPY) in the mouse forced swim test. Peptides 8 (2005) 1394-1400
62. Rigter H., van Riezen H., Wren A., and Schnieden H. Pharmacological validation of a new test for the detection of antidepressant activity of drugs [proceedings]. Br. J. Pharmacol. 59 (1977) 451P-452P
63. Rosier A.M., Orban G.A., and Vandesande F. Regional distribution of binding sites for neuropeptide Y in cat and monkey visual cortex determined by in vitro receptor autoradiography. J. Comp. Neurol. 293 (1990) 486-498
64. Rudolf K., Eberlein W., Engel W., Wieland H.A., Willim K.D., Entzeroth M., Wienen W., Beck-Sickinger A.G., and Doods H.N. The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur. J. Pharmacol. 271 (1994) R11-R13
65. Small C.J., Morgan D.G., Meeran K., Heath M.M., Gunn I., Edwards C.M., Gardiner J., Taylor G.M., Hurley J.D., Rossi M., Goldstone A.P., O'Shea D., Smith D.M., Ghatei M.A., and Bloom S.R. Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 11686-11691
66. Song C., and Leonard B.E. Interleukin-2-induced changes in behavioural, neurotransmitter, and immunological parameters in the olfactory bulbectomized rat. Neuroimmunomodulation 2 (1995) 263-273
67. Song C., and Leonard B.E. The olfactory bulbectomized rat as a model of depression. Neurosci. Biobehav. Rev. 29 (2005) 627-647
68. Song C., Kelly J.P., and Leonard B.E. The effect of stressful behavioral exposure on endocrine and immune parameters in the rat. Stress Med. 10 (1994) 239-245
69. Song C., Earley B., and Leonard B.E. The effects of central administration of neuropeptide Y on behavior, neurotransmitter, and immune functions in the olfactory bulbectomized rat model of depression. Brain Behav. Immun. 10 (1996) 1-16
70. Stanley B.G., and Leibowitz S.F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 3940-3943
71. Strohle A., Poettig M., Barden N., Holsboer F., and Montkowski A. Age- and stimulus-dependent changes in anxiety-related behaviour of transgenic mice with GR dysfunction. NeuroReport 9 (1998) 2099-2102
72. van Riezen H., and Leonard B.E. Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats. Pharmacol. Ther. 47 (1990) 21-34
73. van Riezen H., Schnieden H., and Wren A. Behavioural changes following olfactory bulbectomy in rats: a possible model for the detection of antidepressant drugs [proceedings]. Br. J. Pharmacol. 57 (1976) 426P-427P
74. Vezzani A., Sperk G., and Colmers W.F. Neuropeptide-Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22 (1999) 25-30
75. Watanabe S., Inoue M., and Ueki S. Effects of psychotropic drugs injected into the limbic structures on mouse-killing behavior in the rat with olfactory bulb ablations. Jpn. J. Pharmacol. 29 (1979) 493-496
76. Widdowson P.S., and Halaris A.E. Increased levels of neuropeptide-Y immunoreactivity in rat brain limbic structures following antidepressant treatment. J. Neurochem. 52 (1989) S77
77. Widdowson P.S., and Halaris A.E. Chronic desipramine treatment reduces regional neuropeptide Y binding to Y2-type receptors in rat brain. Brain Res. 539 (1991) 196-202
78. Widdowson P.S., Ordway G.A., and Halaris A.E. Reduced neuropeptide Y concentrations in suicide brain. J. Neurochem. 59 (1992) 73-80
79. Widerlov E., Wahlestedt C., Hakanson R., and Ekman R. Altered brain neuropeptide function in psychiatric illness-with special emphasis on NPY and CRF in major depression. In Proc. C.I.N.P. 15th Congress. Clin. Neuropharmacol. 9 (1986) 572-574
80. Widerlov E., Heilig M., Ekman R., and Wahlestedt C. Possible relationship between neuropeptide Y (NPY) and major depression: evidence from human and animal studies. Nord. J. Psychiatry 42 (1988) 131-137
81. Woldbye D.P., Klemp K., and Madsen T.M. Neuropeptide Y attenuates naloxone precipitated morphine withdrawal via Y5-like receptors. J. Pharmacol. Exp. Ther. 284 (1998) 633-636
82. Yamada M., Takahashi K., Tsunoda M., Nishioka G., Kudo K., Ohata H., Kamijima K., Higuchi T., Momose K., and Yamada M. Differential expression of VAMP2/synaptobrevin-2 after antidepressant and electroconvulsive treatment in rat frontal cortex. Pharmacogenomics J. 2 (2002) 377-382
83. Zarrindast M.R., Sadeghi S., and Sahebgharani M. Influence of alpha-adrenoceptor agonists and antagonists on imipramine-induced hypothermia in mice. Pharmacol. Toxicol. 93 (2003) 48-53