Stabilities of 67Ga- and 111in-labeled transferrin In Vitro

Protein and Peptide Letters

Volumn 16, Issue 2, 2009, Pages 138-142

  Ohtake, Yosuke ^a   Maruko, Akiko ^a   Kuwahara, Yoshikazu ^b   Fukumoto, Manabu ^b   Ohkubo, Yasuhito ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

111In; 67Ga; DTPA; Radiolabeling; Transferrin

Indexed keywords

GALLIUM; INDIUM; PENTETIC ACID; TRANSFERRIN;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; DIALYSIS; ELECTROPHORESIS; PH; PROTEIN STABILITY; RAT;

ANIMALS; DIALYSIS; ELECTROPHORESIS; GALLIUM RADIOISOTOPES; HYDROGEN-ION CONCENTRATION; INDIUM RADIOISOTOPES; PENTETIC ACID; PROTEIN STABILITY; RATS; TRANSFERRIN;

EID: 63449116219     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986609787316298     Document Type: Article

References (25)

1. Ohkubo, Y., Shibuya, A., Kohno, H. and Kubodera, A. Involvement of transferrin in the uptake of 67Ga in inflammatory and normal tissues. (1989) Int. J. Rad. Appl. Instrum. B, 16, 337.
2. Ohkubo, Y., Sawamura, H., Katoh, S., Sasayama, A., Abe, K., Kohno, H. and Kubodera, A. Studies on 67Ga uptake by mouse granuloma tissues. (1991) Int. J. Rad. Appl. Instrum. B, 18, 205.
3. Ohkubo, Y., Sasayama, A., Takegahara, I., Katoh, S., Abe, K., Kohno, H. and Kubodera, A. 67Ga in transferrin-unbound form is taken up by inflamed liver of mouse treated with CC14. (1990) Ann. Nucl. Med., 4, 89.
4. Abe, S., Hasegawa, S., Nirasawa, M., Sato, N. and Ohkubo, Y. Free 67Ga enters into the hepatocytes of carbon tetrachloride-treated rats. (2003) Hepatol. Res., 25, 306.
5. Ohkubo, Y., Araki, S., Abe, K., Takasu, S., Kohno, H. and Kubodera, A. The effect of FeC13 on the accumulation of gallium-67 into inflammatory and normal tissues. (1988) Ann. Nucl. Med., 2, 59.
6. Abe, S., Hasegawa, S., Nirasawa, M., Sasaki, M. and Ohkubo, Y. Transferrin is not involved in the entry of 67Ga into hepatocytes from regenerating liver of partially hepatectomized rats. (2001) Biol. Pharm. Bull., 24, 1343.
7. Sato, R., Abe, S., Yamada, Y., Toyama, D., Ohtake, Y., Sato, N. and Ohkubo, Y. The entering of indium-111 and iron-59 into the hepatocytes from partially hepatectomized rats differ from that of gallium-67. (2004) Biol. Pharm. Bull., 27, 1193.
8. Ohkubo, Y., Abe, K., Kohno, H., Katoh, S. and Kubodera, A. 111In (III) uptake by inflammatory and normal tissues. (1989) Ann. Nucl. Med., 3, 135.
9. Salter-Cid, L., Brunmark, A., Li, Y., Leturcq, D., Peterson, P. A., Jackson, M. R. and Yang, Y. Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis. (1999) Proc. Natl. Acad. Sci. USA, 96, 5434.
10. Roetto, A., Daraio, F., Alberti, F., Porporato, P., Cali, A., De Gobbi, M. and Camaschella, C. Hemochromatosis due to mutations in transferrin receptor 2. (2002) Blood Cells Mol. Dis., 29, 465.
11. Fleming, R. E., Ahmann, J. R., Migas, M. C., Waheed, A., Koef-fler, H. P., Kawabata, H., Britton, R. S., Bacon, B. R. and Sly, W. S. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. (2002) Proc. Natl. Acad. Sci. USA, 99, 10653.
12. Drake, S. F., Morgan, E. H., Herbison, C. E., Delima, R., Graham, R. M., Chua, A. C., Leedman, P. J., Fleming, R. E., Bacon, B. R., Olynyk, J. K. and Trinder, D. Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. (2007) Am. J. Physiol. Gastrointest. Liver Physiol., 292, G323.
13. Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., Said, J. W. and Koeffler, H. P. Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. (2000) J. Biol. Chem., 275, 16618.
14. Lee, A. W., Oates, P. S. and Trinder, D. Effects of cell proliferation on the uptake of transferrin-bound iron by human hepatoma cells. (2003) Hepatology, 38, 967-77.
15. Radoshitzky, S. R., Abraham, J., Spiropoulou, C. F., Kuhn, J. H., Nguyen, D., Li, W., Nagel, J., Schmidt, P. J., Nunberg, J. H. an-drews, N. C., Farzan, M. and Choe, H. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. (2007) Nature, 446, 92.
16. Raje, C. I., Kumar, S., Harle, A., Nanda, J. S. and Raje, M. The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor. (2007) J. Biol. Chem., 282, 3252.
17. Qian, Z. M., Li, H., Sun, H. and Ho, K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. (2002) Pharmacol. Rev., 54, 561.
18. Kojima, S. and Jay, M. Comparisons of labeling efficiency, biological activity and biodistribution among 1251-, 67Ga-DTPA-and 67Ga-DFO-lectins. (1987) Eur. J. Nucl. Med., 13, 366.
19. Arano, Y., Mukai, T., Akizawa, H., Uezono, T., Motonari, H., Wakisaka, K., Kairiyama, C. and Yokoyama, A. Radiolabeled metabolites of proteins play a critical role in radioactivity elimination from the liver. (1995) Nucl. Med. Biol., 22, 555.
20. Hnatowich, D. J., Griffin, T. W., Kosciuczyk, C., Rusckowski, M., Childs, R. L., Mattis, J. A., Shealy, D. and Doherty, P. W. Pharmacokinetics of an indium-Ill-labeled monoclonal antibody in cancer patients. (1985) J. Nucl. Med., 26, 849.
21. Gangopadhyay, A., Petrick, A. T. and Thomas, P. Modification of antibody isoelectric point affects biodistribution of 111-indium-labeled antibody. (1996) Nucl. Med. Biol., 23, 257-61.
22. Krejcarek, G. E. and Tucker, K. L. Covalent attachment of chelating groups to macromolecules. (1977) Biochem. Biophys. Res. Commun., 77, 581.
23. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. Protein measurement with the Folin phenol reagent. (1951) J. Biol. Chem., 193, 265.
24. Vallabhajosula, S. R., Harwig, J. F. and Wolf, W. The mechanism of tumor localization of gallium-67 citrate: role of transferrin binding and effect of tumor pH. (1981) Int. J. Nucl. Med. Biol., 8, 363.
25. Vallabhajosula, S. R., Harwig, J. F. and Wolf, W. Effect of pH on tumor cell uptake of radiogallium in vitro and in vivo. (1982) Eur. J. Nucl. Med., 7, 462.