A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-β and subsequently suppresses TGF-β signalings

FEBS Letters

Volumn 576, Issue 3, 2004, Pages 408-416

  Yagyu, Tatsuo ^a   Kobayashi, Hiroshi ^b   Wakahara, Kiyoshi ^a   Matsuzaki, Hidenori ^a   Kondo, Toshiharu ^c   Kurita, Noriyuki ^d   Sekino, Hideo ^d   Inagaki, Kiyokazu ^a   Suzuki, Mika ^b   Kanayama, Naohiro ^b   Terao, Toshihiko ^b  

^a NetForce Co Ltd   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Nakamura Nagoya 450 0003   (Japan)

^d TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Bikunin; CD44; Dimerization; Ovarian cancer; Signal transduction; TGF receptor

Indexed keywords

CHONDROITIN 4 SULFATE; COLLAGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTOR SUBTYPE; SERINE PROTEINASE INHIBITOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA II RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; ULINASTATIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL STIMULATION; CELLULAR DISTRIBUTION; COLLAGEN SYNTHESIS; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INHIBITION KINETICS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

CELL DIVISION; CELL LINE, TUMOR; CYSTEINE PROTEINASE INHIBITORS; DNA, COMPLEMENTARY; FEMALE; HUMANS; MEMBRANE GLYCOPROTEINS; OVARIAN NEOPLASMS; PROCOLLAGEN; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THYMIDINE; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRYPSIN INHIBITOR, KUNITZ SOYBEAN;

EID: 6344294366     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.09.048     Document Type: Article

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