Urinary trypsin inhibitor efficiently inhibits urokinase production in tumor necrosis factor-stimulated cells

European Journal of Cell Biology

Volumn 71, Issue 4, 1996, Pages 380-386

  Kobayashi, Hiroshi ^a   Gotoh, Junko ^a   Terao, Toshihiko ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Phorbol ester; Protein kinase C; Tumor necrosis factor ; Urinary trypsin inhibitor; Urokinase type plasminogen activator

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CALPHOSTIN C; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN; UROKINASE;

ARTICLE; CELL INVASION; CELL SECRETION; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL LINE; METASTASIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 0029907213     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Albrecht, G. J., K. Hochstrasser, J.-P. Salier: Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, IX. Hoppe-Seyler's Z. Physiol. Chem. 364, 1703-1708 (1983).
2. Balduyck, M., S. Laroui, C. Mizon, J. A. Mizon: A proteoglycan related to the urinary trypsin inhibitor (UTI) links the two heavy chains of inter-alpha-trypsin inhibitor. Biol. Chem. Hoppe-Seyler 370, 329-336 (1989).
3. Barnathan, E. S., A. Kuo, H. Van der Keyl, K. R. McCrae, G. R. Larsen, D. B. Cines: Tissue-type plasminogen activator binding to human endothelial cells. J. Biol. Chem. 263, 7792-7799 (1988).
4. Barnathan, E. S., A. Kuo, K. Kariko, L. Rosenfeld, S. C. Murray, N. Behrendt, E. Ronne, D. Weiner, J. Henkin, D. B. Cines: Characterization of human endothelial cell urokinase-type plasminogen activator protein and messenger RNA. Blood 76, 1795-1806 (1990).
5. Cohen, R. L., X.-P. Xi, C. W. Crowley, B. K. Lucas, A. D. Levinson, M. A. Scuman: Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells. Blood 78, 479-487 (1991).
6. Dano, K., P. A. Andreasen, J. Grondahl-Hansen, P. I. Kristensen, L. S. Nielsen, L. Skriver: Adv. Plasminogen activators, tissue degradation, and cancer. Cancer Res. 44, 139-266 (1985).
7. Hamilton, J. A., D. S. Piccoli, T. Leizer, D. M. Butler, M. Croatto, K. M. Royston: Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts. Proc. Natl. Acad. Sci. USA 88, 7180-7184 (1991).
8. Hochstrasser, K., O. L. Schonberger, I. Rossmanith, E. Wachter: Kunitz-type proteinase inhibitors derived by limited proteolysis of inter-α-trypsin inhibitor, V. Hoppe-Seyler's Z. Physiol. Chem. 362, 1357-1362 (1981).
9. Hochstrasser, K., G. J. Albrecht, O. L. Schonberger, E. Wachter: Kunitz-type protease inhibitors derived by limited proteolysis of the inter-α-trypsin inhibitor, VIII. Hoppe-Seyler's Z. Physiol. Chem. 370, 1689-1696 (1989).
10. Kessler, T. L., G. Markus: Different induction pathways for urokinase (uPA) in A431 cells by EGF and by phorbol ester, TPA. Fibrinolysis 7, 31-40 (1993).
11. Kobayashi, H., J. Gotoh, M. Fujie, T. Terao: Characterization of the cellular binding site for the urinary trypsin inhibitor. J. Biol. Chem. 269, 20642-20647 (1994).
12. Kobayashi, H., H. Shinohara, K. Takeuchi, M. Itoh, M. Fujie, M. Saitoh, T. Terao: Inhibition of the soluble and the tumor cell receptor-bound plasmin by urinary trypsin inhibitor and subsequent effects on tumor cell invasion and metastasis. Cancer Res. 54, 844-849 (1994).
13. Kobayashi, H., H. Shinohara, M. Fujie, J. Gotoh, M. Huh, K. Takeuchi, T. Terao: Inhibition of the metastasis of Lewis lung carcinoma by urinary trypsin inhibitor in the experimental and spontaneous metastasis model. Int. J. Cancer 63, 455-462 (1995).
14. Niedbala, M., M. S. Picarella: Tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon. Blood 79, 678-687 (1992).
15. Perry, J. K., G. K. Scott, C. A. Tse: Modulation of proliferation of cultured human cells by urinary trypsin inhibitor. Biochim. Biophys. Acta 1221, 145-152 (1994).
16. Reisinger, P., K. Hochstrasser, G. J. Albrecht, K. Lempart, J.-P. Salier: Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinases. Biol. Chem. Hoppe-Seyler 366, 479-483 (1985).
17. Rondeau, E., B. Guidet, R. Lacave, M. Bens, J. Sraer, Y. Nagamine, R. Ardaillou, J-D. Sraer: Nordihydroguaiaretic acid inhibits urokinase synthesis by phorbol myristate acetate-stimulated LLC-PK1 cells. Biochim. Biophys. Acta 1055, 165-172 (1992).
18. Tryggvason, K., M. Hoyhtya, T. Salo: Proteolytic degradation of a extracellular matrix in tumor invasion. Biochim. Biophys. Acta 907, 191-217 (1987).
19. Wachter, E., K. Hochstrasser: Kunitz-type protease inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, IV. Hoppe-Seyler's Z. Physiol. Chem. 362, 1351-1355 (1981).
20. Ziegler, A., J. Knesel, D. Fabbro, Y. Nagamine: Protein kinase C down-regulation enhances cAMP-mediated induction of urokinase-type plasminogen activator mRNA in LLC-PK1 cells. J. Biol. Chem. 266, 21067-21074 (1991).