Bupropion (Zyban, Wellbutrin) inhibits nicotine-induced viral reactivation in herpes simplex virus type 1 latent rabbits

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 2, 2004, Pages 640-644

  Myles, Marvin E ^a   Azcuy, Ann M ^a   Nguyen, Ngoc T ^c   Reisch, Eric R ^a   Barker, Steven A ^d   Thompson, Hilary W ^a   Hill, James M ^a,b  

^a LSU EYE CENTER   (United States)

^b LOUISIANA STATE UNIV HLTH SCI C   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; NICOTINE; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATECHOLAMINE RELEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; HERPES SIMPLEX VIRUS 1; LATENT PERIOD; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOKING CESSATION; SUSTAINED RELEASE PREPARATION; TEAR FILM; VIRUS REACTIVATION;

ANIMALS; BUPROPION; DISEASE MODELS, ANIMAL; DOPAMINE UPTAKE INHIBITORS; DRUG INTERACTIONS; EYE; FEMALE; HERPESVIRUS 1, HUMAN; MALE; NICOTINE; RABBITS; VIRUS LATENCY; VIRUS SHEDDING;

EID: 6344291172     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.070862     Document Type: Article

References (36)

1. Alimohammadi H and Silver WL (2000) Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the rat. Chem Senses 25:61-66.
2. Anand R, Conroy WG, Schoepfer R, Whiting P, and Lindstrom J (1991) Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J Biol Chem 266:11192-11198.
3. Ascher JA, Cole JO, Colin JN, Feighner JP, Ferris RM, Fibiger HC, Golden RN, Martin P, Potter WZ, and Richelson E (1995) Bupropion: a review of its mechanism of antidepressant activity. J Clin Psychiatry 56:395-401.
4. Balfour DJ and Ridley DL (2000) The effects of nicotine on neural pathways implicated in depression: a factor in nicotine addiction? Pharmacol Biochem Behav 66:79-85.
5. Benowitz NL and Jacob P (1993) Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers. Clin Pharmacol Ther 53:316-323.
6. Benowitz NL, Jacob P, Fong I, and Gupta S (1994) Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 268:296-303.
7. Colgin MA, Smith RL, and Wilcox CL (2001) Inducible cyclic AMP early repressor produces reactivation of latent herpes simplex virus type 1 in neurons in vitro. J Virol 75:2912-2920.
8. Cooper BR, Wang CM, Cox RF, Norton R, Shea V, and Ferris RM (1994) Evidence that the acute behavioral and electrophysiological effects of bupropion (Wellbutrin) are mediated by a noradrenergic mechanism. Neuropsychopharmacology 11:133-141.
9. Cooper E, Couturier S, and Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature (Lond) 350:235-238.
10. Dani JA and De Biasi M (2001) Cellular mechanisms of nicotine addiction. Pharmacol Biochem Behav 70:439-446.
11. Di Chiara G (2000) Role of dopamine in the behavioural actions of nicotine related to addiction. Eur J Pharmacol 393:295-314.
12. Edwards D and Berry JJ (1987) The efficiency of simulation-based multiple comparisons. Biometrics 43:913-928.
13. Fowler JS, Volkow ND, Wang G-J, Pappas N, Logan J, MacGregor R, Alexoff D, Shea C, Schlyer D, Wolf AP, et al. (1996) Inhibition of monoamine oxidase B in the brains of smokers. Nature (Lond) 379:733-736.
14. Fryer JD and Lukas RJ (1999) Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine and ibogaine. J Pharmacol Exp Ther 288:88-92.
15. Hill JM, Haruta Y, and Rootman DS (1987) Adrenergically induced recurrent HSV-1 corneal epithelial lesions. Curr Eye Res 6:1065-1071.
16. Hsyu P-H, Singh A, Giargiari TD, Dunn JA, Ascher JA, and Johnston JA (1997) Pharmacokinetics of bupropion and its metabolites in cigarette smokers versus nonsmokers. J Clin Pharmacol 37:737-743.
17. Hurt RD, Sachs DPL, Glover ED, Offord KP, Johnston JA, Dale LC, Khayrallah MA, Schroeder DR, Glover PN, Sullivan CR, et al. (1997) A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 337:1195-1202.
18. Jones C (2003) Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin Microbiol Rev 16:79-95.
19. Jorenby DE, Leischow SJ, Nides MA, Rennard SI, Johnston JA, Huges AR, Smith SS, Muramoto ML, Daughton DM, Doan K, et al. (1999) A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 340:685-691.
20. Kwon BS, Gangarosa LP, Burch KD, deBack J, and Hill JM (1981) Induction of ocular herpes simplex virus shedding by iontophoresis of epinephrine into rabbit cornea. Invest Ophthalmol Vis Sci 21:442-449.
21. Liu L, Chang GQ, Jiao YQ, and Simon SA (1998) Neuronal nicotinic acetylcholine receptors in rat trigeminal ganglia. Brain Res 809:238-245.
22. Matta SG, Fu Y, Valentine JD, and Sharp BM (1998) Response of the hypothalamopituitary-adrenal axis to nicotine. Psychoneuroendocrinology 23:103-113.
23. Matta SG, Singh J, and Sharp BM (1990) Catecholamines mediate nicotine-induced adrenocorticotropin secretion via α-adrenergic receptors. Endocrinology 127:1646-1655.
24. Miller CS, Danaher RJ, and Jacob RJ (1998) Molecular aspects of herpes simplex virus I latency, reactivation and recurrence. Crit Rev Oral Biol Med 9:465-474.
25. 3H]norepinephrine. J Pharmacol Exp Ther 302:1113-1122.
26. Myles ME, Alack C, Manino PM, Reish ER, Higaki S, Maruyama K, Mallakin A, Azcuy A, Barker S, Ragan FA, et al. (2003) Nicotine applied by transdermal patch induced HSV-1 reactivation and ocular shedding in latently infected rabbits. J Ocul Pharmacol Ther 19:121-133.
27. Nestler EJ, McMahon A, Sabban EL, Tallman JF, and Duman RS (1990) Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus. Proc Natl Acad Sci USA 87:7522-7526.
28. Schoffelmeer ANM, De Vries TJ, Wardeh G, van de Ven HWM, and Vanderschuren LJMJ (2002) Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. J Neurosci 22:3269-3276.
29. Slemmer JE, Martin BR, and Damaj MI (2000) Bupropion is a nicotinic antagonist. J Pharmacol Exp Ther 295:321-327.
30. Summers KL and Giacobini E (1995) Effects of local and repeated systemic administration of (-)-nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine and serotonin in rat cortex. Neurochem Res 20:753-759.
31. Tella SR, Ladenheim B, and Cadet JL (1997) Differential regulation of dopamine transporter after chronic self-administration of bupropion and nomifensine. J Pharmacol Exp Ther 281:508-513.
32. Thuerauf N, Kaegler M, Dietz R, Barocka A, and Kobal G (1999) Dose-dependent stereoselective activation of the trigeminal sensory system by nicotine in man. Psychopharmacology 142:236-243.
33. Wagner EK and Bloom DC (1997) Experimental investigation of herpes simplex virus latency. Clin Microbiol Rev 10:420-443.
34. Whitley RJ (2001) Herpes simplex viruses, in Fields Virology (Fields BN, Knipe DM, Howley PM eds), 4th ed, pp 2461-2509, Lippincott-Raven, Philadelphia, PA.
35. Wonnacott S (1997) Presynaptic nicotinic ACh receptors. Trends Neurosci 20:92-98.
36. Zevin S, Jacob P, and Benowitz N (1997) Cotinine effects on nicotine metabolism. Clin Pharmacol Ther 61:649-654.