β-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 2, 2004, Pages 617-624

  Avram, Michael J ^a   Krejcie, Tom C ^a   Henthorn, Thomas K ^a,b   Niemann, Claus U ^a,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; INDOCYANINE GREEN; INTRAVENOUS ANESTHETIC AGENT; PHENAZONE; PROPRANOLOL;

AREA UNDER THE CURVE; ARTERIAL BLOOD; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BLOOD FLOWMETRY; BLOOD SAMPLING; COMPARTMENT MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISTRIBUTION; HEART OUTPUT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INTRAVENOUS ANESTHESIA; LIPOPHILICITY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; TOTAL BODY WATER;

ADRENERGIC BETA-ANTAGONISTS; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; CARDIAC OUTPUT; DRUG INTERACTIONS; HUMANS; INDOCYANINE GREEN; MALE; PROPRANOLOL; REGIONAL BLOOD FLOW;

EID: 6344279922     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.070094     Document Type: Article

References (40)

1. Andreu V, Perello A, Moitinho E, Escorsell A, Garcia-Pagan JC, Bosch J, and Rodes J (2002) Total effective vascular compliance in patients with cirrhosis: effects of propranolol. J Hepatol 36:356-361.
2. Avram MJ and Krejcie TC (2003) Using front-end kinetics to optimize target-controlled drug infusions. Anesthesiology 99:1078-1086.
3. Avram MJ, Krejcie TC, and Henthorn TK (2002) The concordance of early antipyrine and thiopental distribution kinetics. J Pharmacol Exp Ther 302:594-600.
4. Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, and Henthorn TK (2000) Isoflurane alters the recirculatory pharmacokinetics of physiologic markers. Anesthesiology 92:1757-1768.
5. Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, and Henthorn TK (1997) The effect of halothane on the recirculatory pharmacokinetics of physiologic markers. Anesthesiology 87:1381-1393.
6. Avram MJ, Sanghvi R, Henthorn TK, Krejcie TC, Shanks CA, Fragen RJ, Howard KA, and Kaczynski DA (1993) Determinants of thiopental induction dose requirements. Anesth Analg 76:10-17.
7. 1 lipoproteins. Proc Exp Biol Med 122:957-963.
8. Barrett PH, Bell BM, Cobelli C, Golde H, Schumitzky A, Vicini P, and Foster DM (1998) SAAM II: simulation, analysis and modeling software for tracer and pharmacokinetic studies. Metabolism 47:484-492.
9. Benowitz N, Forsyth RP, Melmon KL, and Rowland M (1977) Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model. Clin Pharmacol Ther 16:87-98.
10. Brigham KL, Ramsey LH, Snell JD, and Merritt CR (1971) On defining the pulmonary extravascular water volume. Circ Res 29:385-397.
11. Christensen JH and Andreasen F (1990) Individual variation in response to thiopental. Acta Anaesthesiol Scand 72:303-313.
12. Coelho JB, Dvornik D, Mullane JF, Kaufman J, Simon J, Krantz KD, Lee TY, and Perdue HS (1983) Dynamics of propranolol dosing schedules. Clin Pharmacol Ther 34:440-447.
13. Conrad KA, Byers JM 3rd, Finley PR, and Burnham L (1983) Lidocaine elimination: effects of metoprolol and of propranolol. Clin Pharmacol Ther 33:133-138.
14. Davis NR and Mapleson WW (1993) A physiological model for the distribution of injected agents, with special reference to pethidine. Br J Anaesth 70:248-258.
15. Dumont L, Magrassi P, Parent R, Stanley P, and Chartrand C (1984) Effects of propranolol on cardiac dynamics and organ blood flow distribution in dogs. J Auton Pharmacol 4:251-256.
16. Dundee JW, Hassard TH, McGowan WA, and Henshaw J (1982) The 'induction' dose of thiopentone. A method of study and preliminary illustrative results. Anaesthesia 37:1176-1184.
17. Freyschuss U, Hjemdahl P, Juhlin-Dannfelt A, and Linde B (1988) Cardiovascular and sympathoadrenal responses to mental stress: influence of β-blockade. Am J Physiol 24:H1443-H1451.
18. Henthorn TK, Avram MJ, Krejcie TC, Shanks CA, Asada A, and Kaczynski DA (1992) Minimal compartmental model of circulatory mixing of indocyanine green. Am J Physiol 262:H903-H910.
19. Heymann MA, Payne BD, Hoffman JI, and Rudolph AM (1977) Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 20:55-79.
20. Hoffman BB (2001) Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists, in Goodman & Gilman's The Pharmacological Basis of Therapeutics (Hardman JG, Limbird LE, and Gilman AG eds), 10 ed, pp. 215-268, McGraw-Hill, New York.
21. Jacquez JA and Perry TJ (1990) Parameter estimation: local identifiability of parameters. Am J Physiol 258:E727-E736.
22. Johansen JW, Schneider G, Windsor AM, and Sebel PS (1998) Esmolol potentiates reduction of minimum alveolar isoflurane concentration by alfentanil. Anesth Analg 87:671-676.
23. Krejcie TC and Avram MJ (1999) What determines anesthetic induction dose? It's the front-end kinetics, doctor! Anesth Analg 89:541-544.
24. Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, and Henthorn TK (1997) A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs. J Pharmacokinet Biopharm 25:169-190.
25. Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, and Avram MJ (1999) Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid and total body water. J Pharmacol Exp Ther 291:1308-1316.
26. Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, Shanks CA, and Avram MJ (1996a) Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly. J Pharmacol Exp Ther 278:1050-1057.
27. Krejcie TC, Henthorn TK, Shanks CA, and Avram MJ (1994) A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs. J Pharmacol Exp Ther 269:609-616.
28. Krejcie TC, Jacquez JA, Avram MJ, Niemann CU, Shanks CA, and Henthorn TK (1996b) Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs. J Pharmacokinet Biopharm 24:569-588.
29. Krejcie TC, Wang Z, and Avram MJ (2001) Drug-induced hemodynamic perturbations alter the disposition of markers of blood volume, extracellular fluid and total body water. J Pharmacol Exp Ther 296:922-930.
30. London MJ, Zaugg M, Schaub MC, and Spahn DR (2004) Perioperative β-adrenergic receptor blockade: physiologic foundations and clinical controversies. Anesthesiology 100:170-175.
31. Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, and Avram MJ (2000) Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol. Clin Pharmacol Ther 67:342-350.
32. Orme R, Leslie K, Umranikar A, and Ugoni A (2002) Esmolol and anesthetic requirement for loss of responsiveness during propofol anesthesia. Anesth Analg 93:112-116.
33. Price HL (1960) A dynamic concept of the distribution of thiopental in the human body. Anesthesiology 21:40-45.
34. Renkin EM (1952) Capillary permeability to lipid-soluble molecules. Am J Physiol 168:538-545.
35. Renkin EM (1955) Effects of blood flow on diffusion kinetics in isolated perfused hindlegs of cats: a double circulation hypothesis. Am J Physiol 183:125-136.
36. Rowland M (1972) Influence of route of administration on drug availability. J Pharm Sci 61:70-74.
37. Sedek GS, Ruo TI, Frederiksen MC, Shih SR, and Atkinson AJ Jr (1989) Splanchnic tissues are a major part of the rapid distribution spaces of inulin, urea and theophylline. J Pharmacol Exp Ther 251:1026-1031.
38. Soberman R, Brodie BB, Levy BB, Axelrod J, Hollander V, and Steele JM (1949) The use of antipyrine in the measurement of total body water in man. J Biol Chem 179:31-42.
39. Stanley TH, de Lange S, Boscoe MJ, and de Bruijn NL (1982) The influence of chronic preoperative propranolol therapy on cardiovascular dynamics and narcotic requirements during operation in patients with coronary artery disease. Can Anaesth Soc J 29:319-324.
40. Upton RN, Ludbrook GL, Grant C, and Martinez AM (1999) Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration. Anaesth Analg 89:545-552.