Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: Relationships with transition metals iron and copper

Yeast

Volumn 21, Issue 12, 2004, Pages 991-1003

  Melo, R G M ^a   Leitao A C ^a   Padula M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Copper ions; Dipyridyl; DNA repair; Hydrogen peroxide; Iron ions; Neocuproine; NTG2; OGG1; Saccharomyces cerevisiae

Indexed keywords

2,2' BIPYRIDINE; 2,9 DIMETHYL 1,10 PHENANTHROLINE; CATALASE; CHELATING AGENT; COPPER ION; DNA GLYCOSYLTRANSFERASE; DNA POLYMERASE; FUNGAL DNA; HYDROGEN PEROXIDE; IRON; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN NTG2; PROTEIN OGG1; TRANSITION ELEMENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME INACTIVATION; EXCISION REPAIR; FUNGAL GENE; MUTATION RATE; NONHUMAN; NTG2 GENE; OGG1 GENE; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SPONTANEOUS MUTATION;

2,2'-DIPYRIDYL; CHELATING AGENTS; COPPER; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; GENETIC COMPLEMENTATION TEST; HYDROGEN PEROXIDE; IRON; MUTAGENESIS; PHENANTHROLINES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 6344277040     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/yea.1144     Document Type: Article

References (43)

1. Alseth I, Eide L, Pirovano M, et al. 1999. The Saccharomyces cerevisiae homologs of endonuclease III from Escherichia coli, Ntg1 and Ntg2 are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Mol Cell Biol 19: 3779-3787.
2. Asad LM, Medeiros DC, Felzenszwalb I, et al. 2001. effects of low iron conditions on the repair of DNA lesions induced by cumene hydroperoxide in Escherichia coli cells. Mutat Res 485: 339-344.
3. Augeri L, Lee YM, Barton AB, Doistsch PW. 1997. Purification, characterization, gene cloning and expression of Saccharomyces cerevisiae redoxynuclease, a homolog of Escherichia coli endonuclease IH. Biochemistry 36: 721-729.
4. Barbouti A, Doulias PT, Zhu BZ, et al. 2001. Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage. Free Radic Biol Med 31: 490-498.
5. Blakely WF, Fuciarelli AF, Wegher BJ, Dizdaroglu M. 1990. Hydrogen peroxide-induced base damage in deoxyribonucleic acid. Radiat Res 121: 338-343.
6. Boiteux S, Guillet M. 2004. Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae. DNA Repair (Amst). 3: 1-12.
7. Boiteux S, Laval J. 1997. Repair of oxidized purines in DNA. In Base Excision Repair of DNA Damage, Hickson JD (ed.). Landes Bioscience-Springer: Austin, TX.
8. Breen AP, Murphy JA. 1995. Reactions of oxyl radicals with DNA. Free Radic Biol Med 18: 1033-1077.
9. Byrnes RW, Antholine WE, Petering DH. 1992. Oxidation-reduction reactions in Ehrlich cells treated with hydrogen peroxide. Free Radic Biol Med 13: 469-478.
10. Cadet J, Berger M, Douki T, Ravanat JL. 1997. Oxidative damage to DNA: formation, measurement, and biological significance. Rev Physiol Biochem Pharmacol 131: 1-87.
11. Demple B, Harrison L. 1994. Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem 63: 915-948.
12. Dizdaroglu M. 1991. Chemical determination of free radical-induced damage to DNA. Free Radic Biol Med 10: 225-242.
13. Dizdaroglu M. 1992. Oxidative damage to DNA in mammalian chromatin. Mutat Res 275: 331-342.
14. Eide L, Bjoras M, Pirovano M, et al. 1996. Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli. Proc Natl Acad Sci USA 93: 10735-10740.
15. Gellon L, Barbey R, Auffret van der Kemp P, et al. 2001. Synergism between base excision repair, mediated by DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae. Mol Genet Genom 265: 1087-1096.
16. Gellon L, Werner M, Boiteux S. 2002. Ntg2p, a Saccharomyces cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage, interacts with the DNA mismatch repair protein Mlh1p. Identification of a Mlh1p binding motif. J Biol Chem 277: 29 963-29 972.
17. Gietz D, St. Jean A, Woods RA, Schiestl RH. 1992. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20: 1425.
18. Girard PM, Boiteux S. 1997. Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae. Biochimie 79: 559-566.
19. Halliwell B, Gutteridge JMC. 1990. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186: 1-85.
20. Halliwell B, Gutteridge JMC. 1999. Free Radicals in Biology and Medicine, 3rd edn. Oxford Science, Thomson Press: Oxford.
21. Ischenko AA, Saparbaev M. 2002. Alternative incision repair pathway for oxidative DNA damage. Nature 415: 183-187.
22. Karahalil B, Girard PM, Boiteux S, Dizdaroglu M. 1998. Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation or hydrogen peroxide/metal ion-generated free radicals. Nucleic Acids Res 26: 1228-1233.
23. Lea DE, Coulson CA. 1949. The distribution of the numbers of mutants in bacterial populations. J Genet 49: 264-285.
24. Lee DH, O'Connor TR, Pfeifer GP. 2002. Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG → TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells. Nucleic Acids Res 30: 3566-3573.
25. Loeb LA, James EA, Waltersdorph AM, Klebanoff SJ. 1988. Mutagenesis by the autoxidation of iron with isolated DNA. Proc Natl Acad Sci USA 85: 3918-3922.
26. Luo Y, Han ZS, Chin SM, Linn S. 1994. Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA. Proc Natl Acad Sci USA 91: 12 438-12 442.
27. Nakamura J, Purvis ER, Swenberg JA. 2003. Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. Nucleic Acids Res 15: 1790-1795.
28. Popoff SC, Spire AI, Johnson AW, Demple B. 1990. Yeast structural gene (APNI) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci USA 87: 4193-4197.
29. Reed CJ, Douglas KT. 1989. Single-strand cleavage of DNA by Cu(II) and thiols: a powerful chemical DNA-cleaving system. Biochem Biophys Res Commun 162: 1111-1117.
30. Sagripant JL, Kraemer KH. 1989. Site-specific oxidative DNA damage at polyguanosines produced by copper plus hydrogen peroxide. J Biol Chem 264: 1729-1734.
31. Senturker S, Auffret van der Kemp P, You HJ, et al. 1998. Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical. Nucleic Acids Res 26: 5270-5275.
32. Stoewe R, Prutz WA. 1987. Copper-catalyzed DNA damage by ascorbate and hydrogen peroxide: kinetics and yield. Free Rad Biol Med 3: 97-105.
33. Swanson RL, Morey NJ, Doetsch PW, Jinks-Robertson S. 1999. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. Mol Cell Biol 19: 2929-2935.
34. 2. Free Rad Res Commun 7: 1-10.
35. Termini J. 2000. Hydroperoxide-induced DNA damage and mutations. Mutat Res 450: 107-124.
36. Thomas D, Scott AD, Barbey R, et al. 1997. Inactivation of OGG1 increases the incidence of GC → TA transversions in Saccharomyces cerevisiae: evidence endogenous oxidative damage to DNA in eukaryotic cells. Mol Genet Genom 254: 171-178.
37. Tkeshelashvili LK, McBride T, Spence K, Loeb LA. 1991. Mutation spectrum of copper-induced DNA damage. J Biol Chem 266: 6401-6406.
38. van der Kemp PA, Thomas D, Barbey R. 1996. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4- hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci 93: 5197-5202.
39. Wallace SS. 2002. Biological consequences of free radical-damaged DNA bases. Free Radic Biol Med 33: 1-14.
40. Wiederholt CJ, Delaney MO, Greenberg MM. 2002. Interaction of DNA containing Fapy.dA or its C-nucleoside analogues with base excision repair enzymes. Implications for mutagenesis and enzyme inhibition. Biochemistry 41: 15 833-15 844.
41. Wiederholt CJ, Delaney MO, Pope MA, et al. 2003. Repair of DNA containing Fapy.dG and its β-C-nucleoside analogue by formamidopyrimidine DNA glycosylase and MutY. Biochemistry 42: 9755-9760.
42. You HJ, Swanson RL, Harrington C, et al. 1999. Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria. Biochemistry 38: 11 298-11 306.
43. Zielinska-Park J, Nakamura J, Swenberg JA, Aitken MD. 2004. Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene. Carcinogenesis 25: 1727-1733.