HIV type 1 BF recombinant strains exhibit different pol gene mosaic patterns: Descriptive analysis from 284 patients under treatment failure

AIDS Research and Human Retroviruses

Volumn 20, Issue 10, 2004, Pages 1100-1107

  Quarleri, Jorge F ^a   Rubio, Andrea ^a   Carobene, Mauricio ^a   Turk, Gabriela ^a   Vignoles, Moira ^a   Harrigan, Richard P ^b   Montaner, Julio S G ^b   Salomón, Horacio ^a   Gómez Carrillo, Manuel ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

POL PROTEIN; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS RNA;

ARTICLE; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURAL GENE; TREATMENT FAILURE; UNINDEXED SEQUENCE; VIRUS GENE; VIRUS RECOMBINANT; VIRUS STRAIN;

ANTI-HIV AGENTS; ARGENTINA; DRUG RESISTANCE, VIRAL; DRUG THERAPY, COMBINATION; GENES, POL; HIV INFECTIONS; HIV PROTEASE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE INHIBITORS; SEQUENCE ANALYSIS, DNA; TREATMENT FAILURE;

EID: 6344274856     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2004.20.1100     Document Type: Article

References (24)

1. McCutchan FE: Understanding the genetic diversity of HIV-1. AIDS 2000:14(Suppl. 3)S31-S44.
2. Baloria C, Facchi G, Violin M, Van Dooren S, Cozzi-Lepri A, Forbici F, Bertoli A, Riva C, Senese D, Caramello P, Carnevale G, Rizzardini G, Cremonini L, Monno L, Rerza G, Perno CF, Ippolito G, d'Arminio-Monforte A, Vandamme AM, and Moroni M; ICONA Study Group: Increasing prevalence of non-clade B HIV-1 strains in heterosexual men and women, as monitored by analysis of reverse transcriptase and protease sequences. J Acquir Immune Defic Syndr 2001;27(5):499-505.
3. Peeters M and Sharp PM: Genetic diversity of HIV-1: The moving target. AIDS 2000:14(Suppl. 3):S129-S140.
4. Magiorkinis G, Parashevis D, Vandamme A-M, Magiorkinis A, Sypsa V, and Hatzakis A: In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity. J Gen Virol 2003.84:2715-2722.
5. Dowling WE, Kim B, Mason CJ, Wasunna KM, Alam U, Elson L, Birx DL, Robb ML, McCutchan FE, and Carr JK: Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS 2002;16(13): 1809-1820.
6. Carr JK, Avila M, Gomez Carrillo M, Salomon H, Hierholzer J, Watanaveeradej V, Pando MA, Negrete M, Russell KL, Sanchez J, Birx DL, Andrade R, Vinoles J, and McCutchan FE: Diverse BF recombinants have spread widely since the introduction of HIV-1 into South America. AIDS 2001;15:F41-F47.
7. Gómez Carrillo M, Avila M, Hierholzer J, Pando M, Martinez PL, McCutchan FE, and Carr JK: Mother-to-child HIV type 1 transmission in Argentina: BF recombinants have predominated in infected children since the mid-1980s. AIDS Res Hum Retroviruses 2002;18:477-483.
8. Hall, TA: BioEdit: A user-friendly biological sequence alignment editor and analysis program. Ibis Therapeutics, Carlsbad, CA, 1999.
9. Kumar S, Tamura K, Jakobsen IB, Nei M: Mega 2: Molecular evolutionary genetic analysis software. Bioinformatics 2001;17: 1244-1245.
10. Gómez Carrillo M, Quarleri JF, Rubio AE, Carobene MG, Dilernia D, Carr JK, and Salomon H: Drug resistance testing provides evidence of the globalization of HIV-1: A new circulating recombinant form. AIDS Res Hum Retroviruses 2004;20:885-888.
11. Thomson MM, Delgado E, Herrero I, Villahermosa ML, Vazquez-de Parga E, Cuevas MT, Carmona R, Medrano L, Perez-Alvarez L, Cuevas L, and Najera R: Diversity of mosaic structures and common ancestry of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Argentina revealed by analysis of near full-length genome sequences. J Gen Virol 2002;83:107-119.
12. Carobene MG, Rubio AE, Gómez Carrillo M, Magligne M, Kijak GH, Quarleri JF, and Salomon H: Differences in frequencies of drug-resistance associated mutations in the HIV-1 pol gene of B subtype and BF intersubtype recombinant samples. J Acquir Immune Defic Syndr 2004;35(2):207-209.
13. Avila MM, Pando MA, Carrion G, Peralta LM, Salomon H, Carrillo MG, Sanchez J, Maulen S, Hierholzer J, Marinello M, Negrete M, Russell KL, and Carr JK: Two HIV-1 epidemics in Argentina: Different genetic subtypes associated with different risk groups. J Acquir Immune Defic Syndr 2002;29(4):422-426.
14. Hierholzer J, Montano S, Hoelscher M, Negrete M, Hierholzer M, Avila MM, Carrillo MG, Russi JC, Vinoles J, Alava A, Acosta ME, Gianella A, Andrade R, Sanchez JL, Carrion G, Sanchez JL, Russell K, Robb M, Birx D, McCutchan F, and Carr JK: Molecular epidemiology of HIV type 1 in Ecuador, Peru, Bolivia, Uruguay and Argentina. AIDS Res Hum Retroviruses 2002;18(18):1339-1350.
15. Campodonico M, Janssens W, Heyndrickx L, Fransen K, Leonaers A, Fay FF, Taborda M, Van der Groen G, and Fay OJ: HIV type 1 subtypes in Argentina and genetic heterogeneity of the V3 region. AIDS Res Hum Retroviruses 1996;12(1):79-81.
16. Fernandez-Medina D, Jansson M, Rabinovich RD, Libonatti O, and Wigzell H: Identification of human immunodeficiency virus type 1 subtypes B and F BF recombinant and duel infection with these subtypes in Argentina. Scand J Infect Dis 1999;31(3):235-242.
17. Marquina S, Leitner T, Rabinovich RD, Benetucci J, Libonatti O, and Albert J: Coexistence of subtypes B, F, and as BF env recombinant of HIV type 1 in Buenos Aires Argentina. AIDS Res Hum Retroviruses 1996;12(17):1651-1654.
18. Masciotra S, Livellara B, Belloso W, Clara L, Tanuri A, Ramos AC, Baggs J, Lal R, and Pieniazek D: Evidence of a high frequency of HIV-1 subtype F infections in a heterosexual population in Buenos Aires, Argentina. AIDS Res Hum Retroviruses 2000; 16(10):1007-1014.
19. Brindeiro R, Vanderborght B, Caride E, Correa L, Oravec RM, Berro O, Stuyver L, and Tanura A: Sequence diversity of the reverse transcriptase of human immunodeficiency virus type 1 from untreated Brazilian individuals. Antimicrob Agents Chemother 1999;43:1674-1680.
20. Martinez-Picado J, Savara A, Sutton L, and D'Aquila RT: Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J Virol 1999;73:3744-3752.
21. Back NK, Nijhuis M, Keulen W, et al: Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme. EMBO J 1996; 15:4040-4049.
22. Goudsmit J, de Ronde A, de Rooij E, and de Boer R: Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 and 215. J Virol 1997;71:4479-4484.
23. Short GF III, Laikher AL, Lodder M, Shayo Y, Arslan T, and Hecht SM: Probing the S1/S1′ substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues. Biochemistry 2000;39(30):8768-8781.
24. Quarleri JF, Rubio AE, Carobene MG, et al.: Prevalence of HIV-1 drug resistance mutations and relationship with viral subtype among drug-naive infected individuals in Buenos Aires, Argentina. J Clin Microbiol. 2004 submitted.