메뉴 건너뛰기




Volumn 173, Issue 9, 2004, Pages 5495-5500

CD4 phosphorylation partially reverses Nef down-regulation of CD4

Author keywords

[No Author keywords available]

Indexed keywords

3,3 DITHIOBIS(SULFOSUCCINIMIDYLPROPIONATE); BISINDOLYLMALEIMIDE; CD4 ANTIGEN; NEF PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROPIONIC ACID DERIVATIVE; PROTEIN KINASE C INHIBITOR; SERINE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 6344272751     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.9.5495     Document Type: Article
Times cited : (12)

References (42)
  • 1
    • 0024789208 scopus 로고
    • Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells
    • Pelchen-Matthews, A., J. E. Armes, and M. Marsh. 1989. Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells. EMBO J. 8:3641.
    • (1989) EMBO J. , vol.8 , pp. 3641
    • Pelchen-Matthews, A.1    Armes, J.E.2    Marsh, M.3
  • 2
    • 0025089942 scopus 로고
    • Structural features of the cytoplasmic region of CD4 required for internalization
    • Shin, J., C. Doyle, Z. Yang, D. Kappes, and J. L. Strominger. 1990. Structural features of the cytoplasmic region of CD4 required for internalization. EMBO J. 9:425.
    • (1990) EMBO J. , vol.9 , pp. 425
    • Shin, J.1    Doyle, C.2    Yang, Z.3    Kappes, D.4    Strominger, J.L.5
  • 3
    • 0025779089 scopus 로고
    • Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4
    • Shin, J., R. L. Dunbrack, Jr., S. Lee, and J. L. Strominger. 1991. Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4. J. Biol. Chem. 266:10658.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10658
    • Shin, J.1    Dunbrack Jr., R.L.2    Lee, S.3    Strominger, J.L.4
  • 4
    • 0344286482 scopus 로고    scopus 로고
    • Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation
    • Pitcher, C., S. Honing, A. Fingerhut, K. Bowers, and M. Marsh. 1999. Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation. Mol. Biol. Cell 10:677.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 677
    • Pitcher, C.1    Honing, S.2    Fingerhut, A.3    Bowers, K.4    Marsh, M.5
  • 5
    • 0027321454 scopus 로고
    • Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting
    • Pelchen-Matthews, A., I. J. Parsons, and M. Marsh. 1993. Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting. J. Exp. Med. 178:1209.
    • (1993) J. Exp. Med. , vol.178 , pp. 1209
    • Pelchen-Matthews, A.1    Parsons, I.J.2    Marsh, M.3
  • 6
    • 0029655728 scopus 로고    scopus 로고
    • Endocytic and exocytic regulation of CD4 expression and function
    • Marsh, M., and A. Pelchen-Matthews. 1996. Endocytic and exocytic regulation of CD4 expression and function. Curr. Top. Microbiol. Immunol. 205:107.
    • (1996) Curr. Top. Microbiol. Immunol. , vol.205 , pp. 107
    • Marsh, M.1    Pelchen-Matthews, A.2
  • 7
    • 0028173343 scopus 로고
    • The role of Nef in the replication cycle of the human and simian immunodeficiency viruses
    • Cullen, B. R. 1994. The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. Virology 205:1.
    • (1994) Virology , vol.205 , pp. 1
    • Cullen, B.R.1
  • 10
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchhoff, F., T. C. Greenough, D. B. Brettler, J. L. Sullivan, and R. C. Desrosiers. 1995. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332:228.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 228
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Desrosiers, R.C.5
  • 12
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent down-regulation of cell-surface CD4 by nef
    • Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-independent down-regulation of cell-surface CD4 by nef. Nature 350:508.
    • (1991) Nature , vol.350 , pp. 508
    • Garcia, J.V.1    Miller, A.D.2
  • 13
    • 0027158904 scopus 로고
    • Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection
    • Benson, R. E., A. Sanfridson, J. S. Ottinger, C. Doyle, and B. R. Cullen. 1993. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J. Exp. Med. 177:1561.
    • (1993) J. Exp. Med. , vol.177 , pp. 1561
    • Benson, R.E.1    Sanfridson, A.2    Ottinger, J.S.3    Doyle, C.4    Cullen, B.R.5
  • 14
    • 0027315870 scopus 로고
    • CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type I-infected individuals
    • Mariani, R., and J. Skowronski. 1993. CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type I-infected individuals. Proc. Natl. Acad. Sci. USA 90:5549.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5549
    • Mariani, R.1    Skowronski, J.2
  • 15
    • 0033578072 scopus 로고    scopus 로고
    • Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
    • Lama, J., A. Mangasarian, and D. Trono. 1999. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner. Curr. Biol. 9:622.
    • (1999) Curr. Biol. , vol.9 , pp. 622
    • Lama, J.1    Mangasarian, A.2    Trono, D.3
  • 16
    • 0033578016 scopus 로고    scopus 로고
    • Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
    • Ross, T. M., A. E. Oran, and B. R. Cullen. 1999. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr. Biol. 9:613.
    • (1999) Curr. Biol. , vol.9 , pp. 613
    • Ross, T.M.1    Oran, A.E.2    Cullen, B.R.3
  • 18
    • 0037127303 scopus 로고    scopus 로고
    • Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells
    • Cortes, M. J., F. Wong-Staal, and J. Lama. 2002. Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. J. Biol. Chem. 277:1770.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1770
    • Cortes, M.J.1    Wong-Staal, F.2    Lama, J.3
  • 19
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • Lundquist, C. A., M. Tobiume, J. Zhou, D. Unutmaz, and C. Aiken. 2002. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J. Virol. 76:4625.
    • (2002) J. Virol. , vol.76 , pp. 4625
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3    Unutmaz, D.4    Aiken, C.5
  • 21
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • Aiken, C., J. Konner, N. R. Landau, M. E. Lenburg, and D. Trono. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853.
    • (1994) Cell , vol.76 , pp. 853
    • Aiken, C.1    Konner, J.2    Landau, N.R.3    Lenburg, M.E.4    Trono, D.5
  • 22
    • 0028216346 scopus 로고
    • The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef
    • Anderson, S. J., M. Lenburg, N. R. Landau, and J. V. Garcia. 1994. The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef. J. Virol. 68:3092.
    • (1994) J. Virol. , vol.68 , pp. 3092
    • Anderson, S.J.1    Lenburg, M.2    Landau, N.R.3    Garcia, J.V.4
  • 23
    • 0030614819 scopus 로고    scopus 로고
    • The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
    • Mangasarian, A., M. Foti, C. Aiken, D. Chin, J. L. Carpentier, and D. Trono. 1997. The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. Immunity 6:67.
    • (1997) Immunity , vol.6 , pp. 67
    • Mangasarian, A.1    Foti, M.2    Aiken, C.3    Chin, D.4    Carpentier, J.L.5    Trono, D.6
  • 25
    • 0028128822 scopus 로고
    • Myristoylation-dependent binding of HIV-1 Nef to CD4
    • Harris, M. P., and J. C. Neil. 1994. Myristoylation-dependent binding of HIV-1 Nef to CD4. J. Mol. Biol. 241:136.
    • (1994) J. Mol. Biol. , vol.241 , pp. 136
    • Harris, M.P.1    Neil, J.C.2
  • 26
    • 0029795040 scopus 로고    scopus 로고
    • The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef: Mapping of the Nef binding surface by NMR
    • Grzesiek, S., S. J. Stahl, P. T. Wingfield, and A. Bax. 1996. The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef: mapping of the Nef binding surface by NMR. Biochemistry 35:10256.
    • (1996) Biochemistry , vol.35 , pp. 10256
    • Grzesiek, S.1    Stahl, S.J.2    Wingfield, P.T.3    Bax, A.4
  • 27
    • 0033013962 scopus 로고    scopus 로고
    • Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal α helix and proline repeat of Nef selectively regulate MHC-I trafficking
    • Mangasarian, A., V. Piguet, J. K. Wang, Y. L. Chen, and D. Trono. 1999. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal α helix and proline repeat of Nef selectively regulate MHC-I trafficking. J. Virol. 73:1964.
    • (1999) J. Virol. , vol.73 , pp. 1964
    • Mangasarian, A.1    Piguet, V.2    Wang, J.K.3    Chen, Y.L.4    Trono, D.5
  • 28
    • 0029989195 scopus 로고    scopus 로고
    • Nef-CD4 physical interaction sensed with the yeast two-hybrid system
    • Rossi, F., A. Gallina, and G. Milanesi. 1996. Nef-CD4 physical interaction sensed with the yeast two-hybrid system. Virology 217:397.
    • (1996) Virology , vol.217 , pp. 397
    • Rossi, F.1    Gallina, A.2    Milanesi, G.3
  • 29
    • 0035088131 scopus 로고    scopus 로고
    • Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain
    • Preusser, A., L. Briese, A. S. Baur, and D. Willbold. 2001. Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain. J. Virol. 75:3960.
    • (2001) J. Virol. , vol.75 , pp. 3960
    • Preusser, A.1    Briese, L.2    Baur, A.S.3    Willbold, D.4
  • 30
    • 0032488055 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    • Greenberg, M., L. DeTulleo, I. Rapoport, J. Skowronski, and T. Kirchhausen. 1998. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr. Biol. 8:1239.
    • (1998) Curr. Biol. , vol.8 , pp. 1239
    • Greenberg, M.1    DeTulleo, L.2    Rapoport, I.3    Skowronski, J.4    Kirchhausen, T.5
  • 31
    • 0033568211 scopus 로고    scopus 로고
    • Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4
    • Bresnahan, P. A., W. Yonemoto, and W. C. Greene. 1999. Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4. J. Immunol. 163:2977.
    • (1999) J. Immunol. , vol.163 , pp. 2977
    • Bresnahan, P.A.1    Yonemoto, W.2    Greene, W.C.3
  • 32
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    • Craig, H. M., M. W. Pandori, and J. C. Guatelli. 1998. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc. Natl. Acad. Sci. USA 95:11229.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11229
    • Craig, H.M.1    Pandori, M.W.2    Guatelli, J.C.3
  • 33
    • 0038795645 scopus 로고    scopus 로고
    • Signals for sorting of transmembrane proteins to endosomes and lysosomes
    • Bonifacino, J. S., and L. M. Traub. 2003. Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev. Biochem. 72:395.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 395
    • Bonifacino, J.S.1    Traub, L.M.2
  • 34
    • 1842556279 scopus 로고    scopus 로고
    • Adaptable adaptors for coated vesicles
    • Robinson, M. S. 2004. Adaptable adaptors for coated vesicles. Trends Cell. Biol. 14:167.
    • (2004) Trends Cell. Biol. , vol.14 , pp. 167
    • Robinson, M.S.1
  • 35
    • 0030684068 scopus 로고    scopus 로고
    • Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
    • Greenberg, M. E., S. Bronson, M. Lock, M. Neumann, G. N. Pavlakis, and J. Skowronski. 1997. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J. 16:6964.
    • (1997) EMBO J. , vol.16 , pp. 6964
    • Greenberg, M.E.1    Bronson, S.2    Lock, M.3    Neumann, M.4    Pavlakis, G.N.5    Skowronski, J.6
  • 36
    • 0034713437 scopus 로고    scopus 로고
    • Interactions of HIV-1 nef with the μ subunits of adaptor protein complexes 1, 2, and 3: Role of the dileucine-based sorting motif
    • Craig, H. M., T. R. Reddy, N. L. Riggs, P. P. Dao, and J. C. Guatelli. 2000. Interactions of HIV-1 nef with the μ subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. Virology 271:9.
    • (2000) Virology , vol.271 , pp. 9
    • Craig, H.M.1    Reddy, T.R.2    Riggs, N.L.3    Dao, P.P.4    Guatelli, J.C.5
  • 37
    • 0346102461 scopus 로고    scopus 로고
    • Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemi-complexes
    • Janvier, K., Y. Kato, M. Boehm, J. R. Rose, J. A. Martina, B. Y. Kim, S. Venkatesan, and J. S. Bonifacino. 2003. Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemi-complexes. J. Cell Biol. 163:1281.
    • (2003) J. Cell Biol. , vol.163 , pp. 1281
    • Janvier, K.1    Kato, Y.2    Boehm, M.3    Rose, J.R.4    Martina, J.A.5    Kim, B.Y.6    Venkatesan, S.7    Bonifacino, J.S.8
  • 38
    • 0032488027 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    • Bresnahan, P. A., W. Yonemoto, S. Ferrell, D. Williams-Herman, R. Geleziunas, and W. C. Greene. 1998. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. Curr. Biol. 8:1235.
    • (1998) Curr. Biol. , vol.8 , pp. 1235
    • Bresnahan, P.A.1    Yonemoto, W.2    Ferrell, S.3    Williams-Herman, D.4    Geleziunas, R.5    Greene, W.C.6
  • 39
    • 0037438349 scopus 로고    scopus 로고
    • Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling
    • Fragoso, R., D. Ren, X. Zhang, M. W. Su, S. J. Burakoff, and Y. J. Jin. 2003. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J. Immunol. 170:913.
    • (2003) J. Immunol. , vol.170 , pp. 913
    • Fragoso, R.1    Ren, D.2    Zhang, X.3    Su, M.W.4    Burakoff, S.J.5    Jin, Y.J.6
  • 40
    • 0033515427 scopus 로고    scopus 로고
    • Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes
    • Piguet, V., F. Gu, M. Foti, N. Demaurex, J. Gruenberg, J. L. Carpentier, and D. Trono. 1999. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes. Cell 97:63.
    • (1999) Cell , vol.97 , pp. 63
    • Piguet, V.1    Gu, F.2    Foti, M.3    Demaurex, N.4    Gruenberg, J.5    Carpentier, J.L.6    Trono, D.7
  • 41
    • 0032499675 scopus 로고    scopus 로고
    • Solution structure of the cytoplasmic domain of the human CD4 glycoprotein by CD and 1H NMR spectroscopy: Implications for biological functions
    • Wray, V., D. Mertins, M. Kiess, P. Henklein, W. Trowitzsch-Kienast, and U. Schubert. 1998. Solution structure of the cytoplasmic domain of the human CD4 glycoprotein by CD and 1H NMR spectroscopy: implications for biological functions. Biochemistry 37:8527.
    • (1998) Biochemistry , vol.37 , pp. 8527
    • Wray, V.1    Mertins, D.2    Kiess, M.3    Henklein, P.4    Trowitzsch-Kienast, W.5    Schubert, U.6
  • 42
    • 0028843339 scopus 로고
    • Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail
    • Salghetti, S., R. Mariani, and J. Skowronski. 1995. Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc. Natl. Acad. Sci. USA 92:349.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 349
    • Salghetti, S.1    Mariani, R.2    Skowronski, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.